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Affective disorders, or mood disorders, are a group of neuropsychiatric illnesses that are characterized by a disturbance of mood or affect. Most genetic research in this field to date has focused on bipolar disorder and major depression. Symptoms of major depression include a depressed mood, reduced energy, and a loss of interest and enjoyment. Bi...
Citations
... Decades of family studies have provided evidence of a shared familial risk for the development of mood disorders [7]. Specifically, twin and adoption studies indicate the strong contribution of genetic factors in the risk for these psychiatric disorders [8,9]. In fact, genetic factors seem to explain about 35-45% of variance in the etiology of major depression disorder and 65-70% of variance for bipolar disorder [9,10]. ...
... In recent years, the identification of genetic variations that increase the susceptibility for mood disorders has benefited from the introduction of genome-wide associations studies (GWAS) [10][11][12]. From recent studies, it emerged that common genetic variations account for 9-23% of the clinical phenotypic variation in mood disorders [8,10,11]. Conversely, rare genetic variations contribute less to the development of mood disorders as compared with other psychiatric disorders [8]. ...
... From recent studies, it emerged that common genetic variations account for 9-23% of the clinical phenotypic variation in mood disorders [8,10,11]. Conversely, rare genetic variations contribute less to the development of mood disorders as compared with other psychiatric disorders [8]. ...
Mood disorders are highly heritable psychiatric disorders. Over the years, many genetic polymorphisms have been identified to pose a higher risk for the development of mood disorders. To overview the literature on the genetics of mood disorders, a scientometric analysis was performed on a sample of 5342 documents downloaded from Scopus. The most active countries and the most impactful documents in the field were identified. Furthermore, a total of 13 main thematic clusters emerged in the literature. From the qualitative inspection of clusters, it emerged that the research interest moved from a monogenic to a polygenic risk framework. Researchers have moved from the study of single genes in the early 1990s to conducting genome-wide association studies around 2015. In this way, genetic overlaps between mood disorders and other psychiatric conditions emerged too. Furthermore, around the 2010s, the interaction between genes and environmental factors emerged as pivotal in understanding the risk for mood disorders. The inspection of thematic clusters provides a valuable insight into the past and recent trends of research in the genetics of mood disorders and sheds light onto future lines of research.
... For the field of child and adolescent psychiatry, this special issue presents the current status of research into the autism spectrum disorders [3] and anorexia nervosa [4]. For the area of adult psychiatry, affective [5] and schizophrenic [6] disorders are discussed. ...
... The fact that genetic studies identify genes that code for established drug targets (e. g., dopamine D2 receptor in schizophrenic disorders), or for close interaction partners, serves as a proof of principle. Available genetic findings suggest various promising biological fields of intervention for the schizophrenia and bipolar affective disorder spectra [5,6,11,12]. ...
