Fig 5 - available via license: Creative Commons Attribution 4.0 International
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Gene heat map for osteoporosis. Red represents upregulated genes, green represents downregulated genes, black represent no significant difference. C non-osteoporotic controls; T patients with osteoporosis
Source publication
Background
Precision medicine aims to address the demand for precise therapy at the gene and pathway levels. We aimed to design software to allow precise treatment of osteoporosis (OP) with Chinese medicines (CMs) at the gene and pathway levels.
Methods
PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Science...
Context in source publication
Context 1
... By comparing five osteoporosis samples with five non-osteoporotic samples in the GEO database, a total of 21,654 genes were identified. After screening for a P value < 0.05, and |log2 fold change (FC)|> 1, a total of 2789 genes were acquired (1465 upregulated genes and 1324 downregulated genes). As shown by the gene volcano and heat maps (Figs. 4, 5), the differential genes in the disease samples displayed a normal ...
Citations
Mesona chinensis Benth (MCB) is an important medicinal and edible plant in Southern China and Southeast Asian countries. Chloroplast (cp) genome is usually used for plant phylogeny, species identification, and chloroplast genetic engineering. To characterize the cp genome and determine the evolutionary position and perform the genetic diversity analysis of MCB, we sequence and characterize the MCB cp genome. The results show that the cp genome of MCB is a single circular molecule with a length of 152,635 bp. It is a typical quadripartite structure, comprising a large single-copy region (LSC, 83,514 bp) and a small single-copy region (SSC, 17,751 bp) separated by two inverted repeat regions (IRs, 51,370 bp). It encodes 129 unique genes, including 84 protein-coding genes (PCGs), 37 transfer RNAs (tRNAs), and 8 ribosomal RNAs (rRNAs). Altogether 127 simple sequence repeats (SSRs) are identified in the MCB cp genome with 86.61% of mononucleotide repeats. Phylogenetic analysis reveals that MCB is most closely related to Ocimum basilicum based on the whole cp genomes. Several highly divergent regions are found, such as trnH_psbA, rps16_trnQ, trnS_trnG, trnE_trnT, psaA_ycf3, rpl32_trnL, ccsA_ndhD, ndhG_ndhI, and rps15_ycf1, which can be proposed for use as DNA barcode regions. Genetic diversity analysis unveils a relatively narrow genetic basis of MCB germplasm resources. Therefore, the innovative breeding of MCB is very urgent and necessary in future research.
