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![Figure 5. Uvaria valderramensis sp. nov. [A] leaves, [B] fruit...](profile/Allan-Patrick-Macabeo/publication/236597567/figure/fig3/AS:299467199795215@1448409952518/Uvaria-valderramensis-sp-nov-A-leaves-B-fruit-monocarp-C-flower-bud-D_Q320.jpg)
The imperfectly known genus Uvaria (Annonaceae) comprises ca. 20 species of shrubs to small trees in the Philippines. During recent fieldwork at Valderrama, Antique, a suspected new species of Uvaria was collected. Based on morphology, this Uvaria species can be distinguished from other Philippine congeners by its large obovate-lanceolate leaves an...
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... the presence of solitary, leaf-opposed inflorescences (Fig. 2a), numerous stamens and pistils (Fig. 2b), and fused sepals (Fig. 2c) are features that are shared by other Philippine Uvaria species. Among the Philippine species, the divergent Uvaria highly resembles U. panayensis on the basis of leaf shape, texture and venation pattern, and fruits (Fig. 3). However, the divergent Uvaria species is different by having ovate to obtuse sepals (Fig. 2c) and densely pubescent carpels (Fig. 4) in contrast to the reniform sepals and glabrous carpels of U. panayensis. With these distinctions, we propose a new name for the divergent Uvaria species, Uvaria valderramensis Cabuang, Exconde & ...
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... This provides a unique breeding ground for microorganisms such as endophytic fungi found inside plant tissues. The host plant U. valderramensis is known to harbor and produce bioactive secondary metabolites (Cabuang et al. 2012, Macabeo et al. 2014, 2016, Christopher 2022. This has prompted studies related to its associated endophytic fungi. ...
The rise of drug-resistant pathogenic bacteria has enabled the discovery and innovative biotechnological production of antimicrobial substances. Among the widely used strategies to induce antimicrobial substances from fungi is the One Strain Many Compounds (OSMAC) approach where alteration of cultivation parameters are explored. Herein, we report a comparative study on the metabolic profile and antibacterial/antimycobacterial activity of the extracts obtained from the endophytic fungus Fusarium sp. (UST-UVG10) associated with the Philippine endemic Annonaceae plant Uvaria valderramensis using the OSMAC approach. Fusarium sp. (UST-UVG10) was fermented on three
different media (Q6 ½, ZM ½, and YM 6.3) to obtain crude extracts for chemical profiling and antimicrobial activity assessments. Among the three extracts, only the ZM ½ extract exhibited strong inhibition against Staphylococcus aureus (ZOI = 13.85 mm). Evaluation of antituberculosis activity
using the Microplate Alamar Blue Assay (MABA) showed the YM 6.3 extracts to exhibit inhibition against the fast-growing Mycobacterium tuberculosis H37Rv (MIC = 62.0 μg/mL). Metabolic profiling using liquid chromatography-high resolution electrospray ionization mass spectrometry followed by dereplication with Global Natural Product Social Molecular Networking (GNPS) and SIRIUS databases illustrated
induction of the mycotoxin picolinic acid derivative, fusaric acid in ZM ½ and the fungal antibiotic cyclodepsipeptide beauvericin in YM6.3 extracts. Fusaric acid was isolated, characterized, and exhibited profound antibacterial activity against S. aureus (MIC = 1.30 μg/mL) with moderate antimycobacterial activity against M. tuberculosis H37Rv (MIC = 52.4 μg/mL). Overall, the present study demonstrated the correlative influence of culture medium components and the relative abundance of specific antimicrobial compounds, establishing a potential platform for targeted metabolite production.
... Co's Digital Flora of the Philippines (CDFP 2023) has recognized 33 genera with 147 species. The following studies conducted on Annonaceae showed the extent of its distribution and biodiversity in the Philippines, such as Samson (2000), Wang and Saunders (2006), Cabuang et al. (2012), Tang et al. (2013), Arriola et al. (2020), and Dioneda and Alejandro (2022). ...
... Two species of Uvaria were collected, namely, U. valderramensis ( Figure 3J) and U. monticola ( Figure 3I). The former species was first recorded in Valderrama, Antique, and it resembled U. payanensis in leaf blade and corolla shape however, it was distinct in having ovate to obtuse sepals, large ovate to obovate leaves, distinctly yellow corolla lobes, densely pubescent carpels and monocarps oblong with constrictions between seeds, hence were named as a new species (Cabuang et al. 2012), and the latter species is a woody climber 20 m high; the main stem is 8-10 cm in diameter with stellate hairs along veins and midrib above, leaves ovate˗oblanceolate, and the inflorescence is cauliflorous 1-3 flowered, pedicel 6 mm long, 1 mm thick with densely brown stellate hairs. ...
Retuerma-Dioneda A, Alejandro GJD. 2023. Species diversity of Annonaceae in the four selected protected areas in the Bicol Region, Philippines. Biodiversitas 24: 5428-5438. An explorational survey of four selected protected areas (PAs) was conducted in the Bicol region for Annonaceae. The study aimed to provide species diversity of Annonaceae with an account of their endemicity and distribution. The four PAs were the Abasig-Matogdon-Mananap Natural Biotic Area (AMMNBA), Bulusan Volcano Natural Park (BVNP), Mt. Isarog Natural Park (MINP), and Mt. Mayon Volcano Natural Park (MMVNP). Thirty samples were collected and identified, 16 species belonging to 13 genera, namely Annona, Artabotrys, Cananga, Drepananthus, Goniothalamus, Fissistigma, Friesodielsia, Meiogyne, Monoon, Phaeanthus, Polyalthia, Popowia, and Uvaria. Miliuseae is the most species-rich tribe with 7 species (43.75%), followed by Uvarieae with 4 species (25%), Annoneae with 2 species, Canangeae with 2 species (12.5% each), and Xylopieae with 1 species (6.25%). A key of all Annonaceae species collected in the four PAs is provided here. Five Philippine endemic species were identified, namely G. elmeri in the four PAs; P. luzonensis in three PAs; F. lanceolata, and P. lanceolata in AMMNBA; and U. valderramensis in BVNP. AMMNBA has the highest number of species (43%). The species identified comprises 10.88% of the 147 recorded Philippine Annonaceae species. The results highlight the presence and occurrence of Annonaceae essential for management and conservation policy.
... Studies conducted on Annonaceae, however, identified some endemic species. Some of these works were a revisionary study on Cyathocalyx which identified two (2) endemic Annonaceae species˗ Cyathocalyx crissepetalus R.J. Wang & R.M.K. Saunders and Cyathocalyx samarensis R.J. Wang & R.M.K. Saunders (Wang and Saunders 2006); Uvaria valderramensis Cabuang, Exconde & Alejandro, from Antique (Cabuang et al. 2012); Goniothalamus palawanensis C.C. Tang & R.M.K. Saunders from Palawan (Tang et al. 2013); Goniothalamus luzonensis Ferreras & Arriola from Bataan (Arriola et al. 2020). There are 30 known Annonaceae genera with 147 species listed in Co's Digital Flora of the Philippines. ...
Retuerma-Dioneda A, Alejandro GJD. 2022. Inventory of Annonaceae in Abasig-Matogdon-Mananap Natural Biotic Area, Camarines Norte, Bicol, Philippines. Biodiversitas 23: 2213-2224. The Abasig-Matogdon-Mananap Natural Biotic Area (AMMNBA) is a protected area home to endemic plants; however, Annonaceae remains understudied. The study provided a checklist of Annonaceae species in the area and their taxonomic keys, endemicity and conservation status. Field surveys were conducted in January 2020 and July 2021 in San Vicente and Labo, Camarines Norte. The 110 species identified belong to 11 genera- Artabotrys, Drepananthus, Fissistigma, Friesodielsia, Goniothalamus, Meiogyne, Monoon, Phaeanthus, Polyalthia, Popowia, and Uvaria and five (5) tribes: Ambaviodeae, Annoneae, Miliuseae, Uvarieae, and Xylopieae. Four (4) endemic species were recorded: Friesodielsia lanceolata, Polyalthia luzonensis, Polyalthia lanceolata and Goniothalamus elmeri. This study provides baseline information on Annonaceae species in AMMNBA for appropriate conservation policies and proper management of the potential economic benefits.
... The new Philippine endemic Uvaria valderramensis is a small shrub (ca. 3-7 m tall) growing in the lowlands and forests of Valderrama, Antique, Panay Island, Philippines, and is known locally as usog [13]. Its identification and distinction from other Uvaria species were facilitated by morphological and molecular phylogenetic evidences. ...
Tuberculosis is one of the leading causes of death worldwide, more than HIV and malaria. New TB cases are emerging, including multidrug-resistant TB. The development of antimycobacterial assays led to the discovery of secondary metabolites that elicit promising inhibitory activity against Mycobacterium tuberculosis. This review covers literature published from 1999 to 2014 about natural products from Philippine medicinal plants with reported growth inhibitory activity in vitro against M. tuberculosis H37Rv. The antitubercular compounds were grouped according to plant family and/or chemotype. Some exhibited structural significance but with low inhibitory activity (MICs of >128 g/mL). While other previously reported compounds that were re-isolated exhibited anti-TB activity.
