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Background:
Hantavirus pulmonary syndrome (HPS) is well-known in South and North America; however, not enough data exist for the Caribbean. The first report of clinical orthohantavirus infection was obtained in Barbados, but no other evidence of clinical orthohantavirus infections among adults in the Caribbean has been documented.
Methods:
Using...
Contexts in source publication
Context 1
... presentation among orthohantavirus patients is consistent with non-HPS (Table 2). The most common symptoms observed among orthohantavirus patients were headache (80.3%), fever (56.1%), joint pain (47.7%), gastrointestinal-related symptoms (vomiting, diarrhea and abdominal pain) (41.0%), eye (38.3%) and muscle pain (30%) ( Table 2) [26]. ...Context 2
... presentation among orthohantavirus patients is consistent with non-HPS (Table 2). The most common symptoms observed among orthohantavirus patients were headache (80.3%), fever (56.1%), joint pain (47.7%), gastrointestinal-related symptoms (vomiting, diarrhea and abdominal pain) (41.0%), eye (38.3%) and muscle pain (30%) ( Table 2) [26]. Respiratory symptoms and cough were observed in 19.9% of orthohantavirus patients and could be due to orthohantavirus infection or other infections such as influenza, mammarenavirus and or other respiratory viruses (Table 2) [27][28][29]. ...Context 3
... most common symptoms observed among orthohantavirus patients were headache (80.3%), fever (56.1%), joint pain (47.7%), gastrointestinal-related symptoms (vomiting, diarrhea and abdominal pain) (41.0%), eye (38.3%) and muscle pain (30%) ( Table 2) [26]. Respiratory symptoms and cough were observed in 19.9% of orthohantavirus patients and could be due to orthohantavirus infection or other infections such as influenza, mammarenavirus and or other respiratory viruses (Table 2) [27][28][29]. Confirmatory testing of ELISA-seropositive sera was done to establish the veracity of the ELISA results and to serotype the existing orthohantavirus strains in Barbados. ...Citations
... Частицы ортохантавирусов представляют собой сферы, размером 120-160 нм, внутри которой находится геном, представленный сегментированной антисмысловой РНК [6]. Геном PUUV состоит из трех сегментов: S, M и L, кодирующих нуклеокапсидный белок (N белок), предшественника оболочечных гликопротеинов Gn и Gc (GPC) и РНК-зависимую РНК-полимеразу (RdRp), соответственно [7]. ...
... Notably, Bausch et al. (2000) have already pointed towards a higher sensitivity and specificity of the ELISA compared to the IFA in humans [11]. This is a recurrent aspect of ELISA and IFA comparisons, even in contexts outside Lassa fever or other infectious diseases, such as schistosomiasis, leishmaniasis, or hantavirus disease [30][31][32]. ...
... Notably, Bausch et al. (2000) have already pointed towards a higher sensitivity and specificity of the ELISA compared to the IFA in humans [11]. This is a recurrent aspect of ELISA and IFA comparisons, even in contexts outside Lassa fever or other infectious diseases, such as schistosomiasis, leishmaniasis, or hantavirus disease [30][31][32]. ...
The aim of this study was to evaluate the use of a capture enzyme-linked immunosorbent assay (ELISA) for the detection of LASV-reactive IgG antibodies in Mastomys rodents. The assay was used for laboratory-bred Mastomys rodents, as well as for animals caught in the wild in various regions of West Africa. The ELISA reached an accuracy of 97.1% in samples of known exposure, and a comparison to an immunofluorescence assay (IFA) revealed a very strong agreement between the ELISA and IFA results (Cohen’s kappa of 0.81). The agreement is valid in Nigeria, and in Guinea and Sierra Leone where the lineages II and IV are circulating, respectively. Altogether, these results indicate that this capture ELISA is suitable for LASV IgG serostatus determination in Mastomys rodents as an alternative to IFA. This assay will be a strong, accurate, and semi-quantitative alternative for rodent seroprevalence studies that does not depend on biosafety level 4 infrastructures, providing great benefits for ecology and epidemiology studies of Lassa fever, a disease listed on the Research and Development Blueprint of the WHO.
... The majority of studies took place in South America-five had been conducted in Brazil [41,44,45,49,54], three in Argentina [50][51][52], and one each in Chile [53], Paraguay [48], and Bolivia [47]. One study was conducted in Central America (Panama) [46] and one in the Caribbean (Barbados) [56]. All selected studies were conducted with various model designs using aggregated data sets. ...
... Two studies performed descriptive and Bayesian regressional data analyses [41,45], one study utilised a zero inflated model tailored to count data with excessive zero counts [49], and another used an ecological niche model (ENM) examining the relationships between humans, rodent species and the environments where they occur [44]. Other studies used GLMs and a MaxEnt model [50,51], ARIMA and dynamic regression models [52,53], a cross-sectional epidemiology method [56], and outbreak investigation designs [46][47][48], respectively (Tables 1 and 2). ...
... The time span of study data ranged from one to 23 years, based on monthly, seasonal, or annual climate data with varying time lags (Table 1). Rainfall or precipitation (including snow) was the climatic factor or exposure assessed in all selected studies, while temperature appeared in all selected studies except seven, namely Donaliso [44], Donaliso [45], Andreo [50], Montgomery [47], Bayard [46], Williams [48] and Douglas et al. [56]. Nsoesie et al. [53] analysed relative air humidity. ...
Background:
With the current climate change crisis and its influence on infectious disease transmission there is an increased desire to understand its impact on infectious diseases globally. Hantaviruses are found worldwide, causing infectious diseases such as haemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS)/hantavirus pulmonary syndrome (HPS) in tropical regions such as Latin America and the Caribbean (LAC). These regions are inherently vulnerable to climate change impacts, infectious disease outbreaks and natural disasters. Hantaviruses are zoonotic viruses present in multiple rodent hosts resident in Neotropical ecosystems within LAC and are involved in hantavirus transmission.
Methods:
We conducted a systematic review to assess the association of climatic factors with human hantavirus infections in the LAC region. Literature searches were conducted on MEDLINE and Web of Science databases for published studies according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) criteria. The inclusion criteria included at least eight human hantavirus cases, at least one climatic factor and study from > 1 LAC geographical location.
Results:
In total, 383 papers were identified within the search criteria, but 13 studies met the inclusion criteria ranging from Brazil, Chile, Argentina, Bolivia and Panama in Latin America and a single study from Barbados in the Caribbean. Multiple mathematical models were utilized in the selected studies with varying power to generate robust risk and case estimates of human hantavirus infections linked to climatic factors. Strong evidence of hantavirus disease association with precipitation and habitat type factors were observed, but mixed evidence was observed for temperature and humidity.
Conclusions:
The interaction of climate and hantavirus diseases in LAC is likely complex due to the unknown identity of all vertebrate host reservoirs, circulation of multiple hantavirus strains, agricultural practices, climatic changes and challenged public health systems. There is an increasing need for more detailed systematic research on the influence of climate and other co-related social, abiotic, and biotic factors on infectious diseases in LAC to understand the complexity of vector-borne disease transmission in the Neotropics.
... To understand the possible rodent reservoirs of orthohantaviruses, mammarenaviruses and orthopoxviruses in Barbados, a rodent trapping and sampling survey was conducted in 2019. A total of 160 rodents were trapped over 10 trapping nights from 15th January to 26th January 2019, at a total of 15 trapping sites around Barbados including chicken farms, recycling centres, horse stables, an agriproducts retail store, residential neighbourhoods, the national geriatric hospital, and sugarcane fields in parishes where previously recorded human orthohantavirus cases occurred (Table 1 & Figure 1) [30]. 58 70 Key: N-non-scrotal male; SC-scrotal; PR-pregnant; NP-non-parous; *-with 4 female Mus musculus and 1 female Rattus norvegicus rodents, their reproductive status was either indiscernible or inadvertently not recorded. ...
... To understand the possible rodent reservoirs of orthohantaviruses, mammarenaviruses and orthopoxviruses in Barbados, a rodent trapping and sampling survey was conducted in 2019. A total of 160 rodents were trapped over 10 trapping nights from 15th January to 26th January 2019, at a total of 15 trapping sites around Barbados including chicken farms, recycling centres, horse stables, an agriproducts retail store, residential neighbourhoods, the national geriatric hospital, and sugarcane fields in parishes where previously recorded human orthohantavirus cases occurred (Table 1 & Figure 1) [30]. 76.5% (52/68) were non-parous and with 5.9% (4/68) of the female M. musculus rodents the reproductive maturity was either indiscernible or not recorded (Table 1). ...
... High rainfall can be associated with increased orthohantavirus transmission, as higher infection rates were observed during the wet season compared to the dry season since rainfall can permit moist soil which facilitates rodent burrowing, breeding, survival and the proliferation of vegetation and food for rodents [4,47]. The rainy season in Barbados has been associated with higher human orthohantavirus prevalence rates, with peaks occurring in the months of August and September [30]. A lower orthohantavirus seroprevalence of 3.8% was observed in this study compared to the previous rodent study, with a 29% seroprevalence rate. ...
Background:
Rodents are reservoirs for several zoonotic pathogens that can cause human infectious diseases, including orthohantaviruses, mammarenaviruses and orthopoxviruses. Evidence exists for these viruses circulating among rodents and causing human infections in the Americas, but much less evidence exists for their presence in wild rodents in the Caribbean.
Methods:
Here, we conducted serological and molecular investigations of wild rodents in Barbados to determine the prevalence of orthohantavirus, mammarenavirus and orthopoxvirus infections, and the possible role of these rodent species as reservoirs of zoonotic pathogens. Using immunofluorescent assays (IFA), rodent sera were screened for the presence of antibodies to orthohantavirus, mammarenavirus (Lymphocytic choriomeningitis virus-LCMV) and orthopoxvirus (Cowpox virus-CPXV) infections. RT-PCR was then conducted on orthohantavirus and mammarenavirus-seropositive rodent sera and tissues, to detect the presence of viral RNA.
Results:
We identified antibodies against orthohantavirus, mammarenavirus, and orthopoxvirus among wild mice and rats (3.8%, 2.5% and 7.5% seropositivity rates respectively) in Barbados. No orthohantavirus or mammarenavirus viral RNA was detected from seropositive rodent sera or tissues using RT-PCR.
Conclusions:
Key findings of this study are the first serological evidence of orthohantavirus infections in Mus musculus and the first serological evidence of mammarenavirus and orthopoxvirus infections in Rattus norvegicus and M. musculus in the English-speaking Caribbean. Rodents may present a potential zoonotic and biosecurity risk for transmission of three human pathogens, namely orthohantaviruses, mammarenaviruses and orthopoxviruses in Barbados.
Background:
Hantavirus and dengue virus infections lead to diseases causing economic and public health concerns. Acute hantavirus infections can lead to similar clinical haemorrhagic signs as other endemic diseases including dengue and leptospirosis.
Methods:
Using a retrospective case analysis of pregnant dengue and hantavirus disease patients with clinical reports and compatible clinical laboratory information during pregnancy, we report the first evidence of dengue and hantavirus infections and a case of dual dengue and hantavirus infection among pregnant women in the Caribbean. Laboratory testing by enzyme-linked immunosorbent assay (ELISA) and non-structural protein 1 (NS1) for DENV and for hantavirus infection pseudotype focus reduction neutralisation tests (pFRNT), ELISA and immunochromatographic (ICG) strips.
Results:
Four pregnant cases with acute DENV infections were identified; however, only one out of the four cases (25%) had a detailed medical record to permit abstraction of clinical data. Six hantavirus infected pregnant cases were identified with gestation periods ranged from 36 to 39 weeks; none of the reported patients exhibited previous pregnancy complications prior to hospitalisation and infection. Acute liver damage was observed in three of the six cases (AST readings) who were subsequently diagnosed with hepatitis in pregnancy and variable clinical outcomes were observed with term and pre-term deliveries.
Conclusions:
Whilst hantavirus infection in pregnancy is rare, consideration should be given to differential diagnosis with fever, kidney involvement, liver involvement, haemorrhagic symptoms and thrombocytopenia in endemic areas with clinically similar diseases such as dengue and leptospirosis.HighlightsFirst recorded case of hantavirus and dengue co-infection in a pregnant woman.First detailed report of clinical hantavirus infection in pregnant women in the Caribbean.First published report of clinical dengue infection in pregnant woman in the Caribbean.Possible complications of pregnancy following hantavirus infection.Pre-term birth and low birth weights.Clinical course of hantavirus infection in a Caribbean population.
