Table 3 - available via license: CC BY
Content may be subject to copyright.
Source publication
Abstract Background This study aims to clinically verify the effects of myrtle essential oil, which has non-irritation, non-toxicity, and non-sensitivity characteristics among natural materials, by applying the oil to acne skin of Korean women, with special emphasis on a development of natural substances with a high safety to relieve acne and minim...
Context in source publication
Similar publications
Objectives: Estimate the incidence of the confounding lesions (CL) with pressure injuries in an intensive care unit of an oncology hospital, to characterize the patients and the confused injuries. Methods: Prospective cohort study conducted in an adult intensive care unit of an oncology hospital in Belo Horizonte, Minas Gerais. The sample consisted...
Citations
... This infection causes chronic skin lesions and leaves permanent scars with deformation of the infected area. A study by Kim et al. [68] has clinically proven that MCLO has the effect of convergence, reduction of erythema, removal of sebum and dead skin cells, and antibacterial effect on the facial skin of Korean women. These studies show that MCLO is a safe, skin-soothing substance that effectively treats acne. ...
Acne is a chronic, common disease that poses a significant therapeutic, psychological and social problem. The etiopathogenesis of this disease is not fully understood. Drugs used in general and external therapy should have anti-seborrhoeic, anticomadogenic, bactericidal, bacteriostatic, and anti-inflammatory properties. Acne treatment is often associated with the long-term use of antibiotics, contributing to the global antibiotic resistance crisis. In order to solve this problem, attention has been paid to essential oils and their terpene components with potent antimicrobial, anti-inflammatory, and antioxidant properties. Research shows that certain essential oils effectively reduce inflammatory acne lesions through mechanisms related to the sebaceous glands, colonization of Cutibacterium acnes, and reactive oxygen species (ROS). An example is tea tree oil (TTO), a more commonly used topical agent for treating acne. TTO has antimicrobial and anti-inflammatory activity. The paper presents the latest scientific information on the activity and potential use of specific essential oils in treating acne. Evidence of antibacterial, anti-inflammatory, and antioxidant activity of several essential oils and their main components was presented, indicating the possibility of using them in the treatment of acne.
... To verify the effects of MC essential oil in acne and skin irritation MC essential oil every morning and evening for 6 weeks 20 Korean women those who have not used any acne treatment Two group simple randomize trial ------------MC essential oil is a safe effective substance for treating acne with skin-soothing effects from the results of reduced erythema [68] 4. ...
Myrtus communis Linn. (MC) is an important medicinal shrub being used in Unani Medicine for the
treatment of diarrhoea, peptic ulcers, leucorrhoea, urethritis, haemorrhoids, conjunctivitis, palpitation,
pulmonary and skin disease. This review provides data on the botany, phytochemical, Preclinical &
Clinical Studies and Unani traditional uses of MC, with an aim to make update of the current information
and obtain opportunities for further therapeutic potential. The information was obtained from scientific
literature databases including PubMed, Research Gate, Google Scholar, Web of Science and Science
Direct. Additional information was gathered from classical Unani text books, and published materials.
MC are used traditionally for the treatment so many diseases. The Anti-inflammatory, Antimicrobial,
Antioxidant, Hypoglycaemic, Anticancer, Analgesic, Antidiarrheal properties have been widely
investigated. More than 50 active ingredients have been isolated from this plant including monoterpene,
sesquiterpene, oxygenated sesquiterpenes, tannins and flavonoids. The present review verifies the real
identity of Myrtle, summarizes its valuable description in Unani literature, and its medicinal efficacy in
haemorrhoid, aphthous stomatitis, chronic rhinosinusitis, bacterial vaginosis (BV) and other disorders.
Phytochemical and pharmacological studies and clinical investigations on the crude drug and isolated
principles proved the multipotent action of Myrtle.
... [248,249] 6 EOs can exert self-anti-acne action on microbial species like P. acnes or S. aureus. [250] Considering the antimicrobial effects of essential oils for application in acne treatment as a part of a pharmaceutical product, the potential of the following oil models can be appreciated: Acacia dealbata essential oil, Achillea millefolium essential oil, Boswellia carterii essential oil, Camellia sinensis essential oil, Citrus aurantifolia essential oil, Commiphora myrrha essential oil, Helichrysum italicum essential oil, Laurus nobilis essential oil, Lavandula angustifolia essential oil, Mentha piperita essential oil, Myrthus communis essential oil, Ocimum basilicum essential oil, Jasminum grandiflorum essential oil, Santalum album essential oil, Pogostemon patchouli essential oil, Rosmarinus officinalis essential oil, Salvia lavandulifolia essential oil, Thymus vulgaris essential oil, Vetiveria zizanioides essential oil, Viola odorata essential oil [250][251][252][253]. ...
With a fascinating complexity, governed by multiple physiological processes, the skin is considered a mantle with protective functions which during lifetime are frequently impaired, triggering dermatologic disorders. As one of the most prevalent dermatologic conditions worldwide, characterized by a complex pathogenesis and a high recurrence, acne can affect the patient’s quality of life. Smart topical vehicles represent a good option in the treatment of a versatile skin condition. By surpassing the stratum corneum known for diffusional resistance, a superior topical bioavailability can be obtained at the affected place. In this direction, the literature study presents microemulsions as a part of a condensed group of modern formulations. Microemulsions are appreciated for their superior profile in matters of drug delivery, especially for challenging substances with hydrophilic or lipophilic structures. Formulated as transparent and thermodynamically stable systems, using simplified methods of preparation, microemulsions have a simple and clear appearance. Their unique structures can be explained as a function of the formulation parameters which were found to be the mainstay of a targeted therapy.
... al., 2017). In addition, the drugs from medicinal plants are used to treat acne (Kim et al., 2018). Major modes of action for common acne treatment agents have antimicrobial activity, anti-inflammatory action, the normalization of follicular hyperkeratinization and the reduction of sebum production (Nasri et al., 2015;Malhi et al., 2017). ...
Background. Acne is a very common dermatological condition, very few studies have been done regarding the knowledge, beliefs, and perceptions about the various treatment modalities and causative factors (nutrition, medication, cosmetics, pollutants, psychological and lifestyle factors and etc.) of acne. Methods. A quantitative written survey was performed. Survey sample – 451 young people 18-34 years old. Data analysis was performed using SPSS 26.0, calculated percentage frequencies, mean and standard deviation (SD), Pearson’s Chi Square test was used to detect statistically significant differences and correlation analysis was performed using the Spearman correlation. Results. The study shows that acne affects 49.9% of the surveyed young people. The prevalence of acne depends on the type of skin, tendency to have skin imperfections and genetic factors. Awareness and perception of skin care, factors affecting the occurrence of acne, and treatments used do not depend on the age of respondents. Conclusions. Young people lack professional knowledge of acne, skin care, and acne-provoking factors. They should take care of themselves, choose the right information from reliable sources and seek the help of specialists. Identifying the negative exogenous and endogenous factors and thus reducing their impact are mandatory for an adequate acne management.
Background
Ethnobotanical studies investigating a large number of traditional herbs and uses have an important role in the discovery of new drugs. Nowadays, some of these traditional herbs are researched directly in the clinical trials. In this study, it is aimed to evaluate the 19 plant species that have been identified in the clinical trials among 300 plant species belonging to 79 families with traditional use for skin problems in Turkey.
Main body
Natural sources are very important to treat diseases for thousands of years. The ethnopharmacological research of natural products ranges from the collection of biogenic samples such as plants to preclinical and clinical studies with the aim of developing drug templates or new drugs. In the ethnopharmacological approach, it is aimed to reach the result based on the traditional and modern knowledge about natural resources. The biggest advantage of this approach is synthesizing new and old information. After the plant or natural compound is determined, other processes work similarly with conventional drugs.
Methods
Ethnobotanical papers, thesis and projects in Istanbul University Faculty of Pharmacy Department of Pharmaceutical Botany and databases (PubMed and Google Scholar) have been sought and results were synthesized.
Results
Most of the clinical uses of herbs have been seen similar to their traditional uses. On the other hand, there are some plants on which their clinical uses differ from the traditional uses such as Borago officinalis, Calendula officinalis or Euphorbia peplus. When the frequency of traditional uses of herbs are compared, Plantago species, Plantago major and Plantago lanceolata are the most used taxa in Turkey, secondly, Hypericum perforatum comes. However, Plantago species are not of much interest in clinical trials. It is seen that most of the plants in the clinical research are tried for wound healing occuring due to different origins such as cancer, surgery and injury.
Side effects were observed only during the application of Allium cepa, Cydonia oblonga and H. perforatum.
Conclusions
When clinical trials are evaluated in terms of efficacy and overall results, significant differences and effective results are seen in treatment groups given herbs in comparison with placebo or control groups.
Background: The outbreak of COVID-19 has spread quickly all over the world. Apparently, the uncontrolled increases in the inflammatory and the immune processes are its major pathologies. Therefore, the use of natural plants containing antioxidant factors for the regulation of the immune system can be useful for the inflicted patients. Many epidemic diseases have occurred throughout human history. Persian physicians such as Avicenna offered solutions to these epidemics that were helpful in controlling these diseases. Objective: In this study, we introduce the herbs according to traditional Persian medicine’s point of view that confirm their having antitussive, antipyretic, anti-viral, anti-inflammatory and antioxidant effects. Methods: In this regard, a thorough search was done on the detoxifier and immuno-modulatory plants in the Persian medicine books such as Makhzan-ol Advieh” and “Tohfat ol momenin” and “Qanun fi al tib”. Then, the herbs that were effective in fever and pulmonary diseases were browsed and arranged, and their pharmacological properties were also searched in the scientific databases. Results: This study examined the antipyretic, antitussive and immune-enhancing properties of the plants cited in Persian medicine books and showed that plants such as orange, sweat lemon, citron, myrtle and lavender have antipyretic, antitussive, anti-inflammatory, antioxidant and antimicrobial properties. Conclusion: It seems that the introduced plants could be potential candidates for animal studies and clinical trials. However, more studies are needed to prove their specific effectiveness.
Objectives:
Although Acne vulgaris is a chronic skin disease, which its standard treatment causes therapeutic limitations and some common adverse effects, medicinal plants can be effective in treatment with low adverse effects as combination therapy. Myrtle (Myrtus Communis) has some beneficial properties, which has been administered topically and orally for some skin diseases in Persian medicine. This study aimed to compare the efficacy and safety of Myrtle formula and 1% clindamycin topical solution.
Methods:
This was a split-face clinical trial that was done on 55 patients with mild to moderate acne vulgaris for 16 weeks. The patients received topical Myrtle solution to the right side of the face (group 1) and clindamycin solution to the left side (group 2) twice daily for 12 weeks. All participants were examined for the acne severity index (ASI) and total acne lesions counting (TLC) at certain times during the study. Then, they stopped using them for four weeks. They also did not take the drug in the final four weeks of the study.
Results:
Forty-eight patients completed the study for 16 weeks; 40 (83.2%) patients were female and the rest of them were male. The mean age and standard deviation were 25.62 ± 7.62 years. After 12 weeks, the percentage changes of comedones, inflammatory lesions, ASI and TLC were significantly reduced in both groups (p < 0.001). The percentage change of inflammatory lesions and ASI decrease was significantly higher in the group 1 (p = 0.03). There was no significant difference in the incidence of side effects between the two groups. There was a more significant decrease in sebum percentage change in the group 1 (p = 0.003).
Conclusion:
Myrtle lotion was effective and safe for the treatment of mild to moderate acne vulgaris.
Myrtus communis L. is one of the important aromatic and medicinal species from the Mediterranean area. It is used in various fields such as culinary, cosmetic, pharmaceutical, therapeutic, and industrial applications. Thus, a Box–Wilson experimental plan was used in this study to select the optimal operating conditions in order to obtain high volumes of essential oils. The factorial design method was applied to evaluate at an industrial scale the effect of major process variables on the essential oil extraction from Myrtus communis L. herbs by the steam distillation method. The input variables considered as significant operating conditions were: X1—boiler occupancy rate (boilers were filled to 50%, 75%, and 100%), X2—distillation duration (distillation was continued 60, 75, and 90 min), and X3—particle size (herbs were cut in sizes of 10, 20, and 30 mm via guillotine). The dependent variable selected, coded as Y, was the essential oil volume obtained (mL). The steps of the classical statistical experimental design technique were complemented with the Taguchi method to improve the extraction efficacy of essential oil from Myrtus communis L., and the optimum parameter conditions were selected: boiler occupancy rate 100%, distillation duration 75 min, and particle size 20 mm. Following the optimum parameters, the GC-MS assay revealed for the Myrtus communis L. essential oil two predominant components, α-pinene—33.14% and eucalyptol—55.09%.
