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Background
Duraplasty refers to the neurosurgical process of reconstructing dural defect. Variety of materials is used for such reconstruction, including natural, semisynthetic, and synthetic materials. Although synthetic materials are readily available and easy to apply, these are associated with foreign body reaction which may lead to serious con...
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Citations
Though the indications are quite varied, decompressive craniectomy is considered as a lifesaving procedure. Many studies in the literature have shown that effectiveness of craniectomy is to its maximum when in addition to bone removal the Dura-matter is opened properly and is augmented with duraplasty.(1) Different synthetic materials have been used over decades as a replacement/substitute of the dura during the decompressive craniectomy, the purpose of using synthetic dura matter substitute is to provide a layer for protection for brain tissue & minimize adhesions of brain to galea which indeed helps in dissection during performing the cranioplasty later. Previously in our institution we have been using different synthetic dural replacement including Neuropatch, Duragene, Layoplant. In this case series we described four cases which had excessive granulation tissue formation in response to a newly used synthetic Dural substitute (Redura) after decompressive craniectomy done on emergency basis. During the follow up brain imaging at different intervals, these four patients were found to have foreign body reaction in the form of excessive granulation tissue formation, in addition to that, one case had a sterile pus like collection. The granulation tissue diagnosis was affirmed by histopathology in all the 4 cases.
