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In this short review, the current knowledge on the chemical constituents and pharmacology of two lesser-known Hibiscus species of H. taiwanensis and H. schizopetalus is updated with some description of their botany and uses. With phenolic acids, flavonoids, phenylpropanoids, and sterols as chemical constituents, H. taiwanensis has pharmacological p...
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... hibiscus) is a fast-growing shrub that can reach up to 3 m in height 2 . Leaves and flowers of H. schizopetalus resemble those of Hibiscus rosa-sinensis (Figure 3). Flowers are solitary, pendulous with a long extended style, and petals are bright red, finely dissected and strongly reflexed. ...
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The present study is aimed to investigate the phytochemistry along with TLC and develop High Performance Thin Layer Chromatography (HPTLC) fingerprint profile for the first time of the three different extracts viz. acetone, methanol and aqueous extracts of the flower of Elaeagnus latifolia, the wild edible plant used by the tribal people of Meghala...
Citations
... Indonesia, as a country with high diversity, uses the Hibiscus schizopetalus (Kembang sepatu gantung) as an ornamental plant, and the people of North Maluku use it to induce labor and improve the condition of pregnant women [10]; the people of Colombia use an infusion of H. schizopetalus flowers to treat colds and coughs [11]. In Malaysia, H. schizopetalus is also a medicinal plant because it contains chemical compounds, including anthocyanins and triterpene esters, such as antioxidants, antipyretic, anti-inflammatory, analgesic, hypoglycemic, and hypolipidemic [12]. Hibiscus schizopetalus was chosen in this study because it is suspected to have active compounds that act as lipase inhibitors. ...
The group screened and identified the content of Hibiscus schizopetalus by protein–protein interaction, molecular docking, and dynamics as a potential therapy for obesity through pancreatic lipase (PNLIP) as a protein target. First, the group collected all active ingredients of H. schizopetalus from an online database [http://www.knapsackfamily. com/ and http://ijah.apps.cs.ipb.ac.id/] to identify and isolate active compounds. The 3-D structures and canonical of the active compound were taken from the PubChem database, and then all compounds were analyzed by pkCSM and Tox-Protox II to get pharmacokinetics and physical-chemistry properties. The protein target of obesity was identified using the Open Target Platform. After the protein targets of plant extract and obesity were collected, the group analyzed them using Cytoscape. Protein–protein interaction was analyzed using String, Gene ontology, and KEGG pathway. Virtual screening was done by Pyrx software, and visualization was done by Discovery Studio Biovia, proceed by molecular docking using AutoDockTools-1.5.7, and finally, molecular dynamics (MDs) was done using YASARA software. The group collected 70 compounds from a research journal and found 196 protein targets. The target of obesity was 165 protein targets. The 196 protein targets of H. schizopetalus and 165 protein targets were analyzed and merged using Cytoscape and 11 proteins targeting H. schizopetalus and obesity. After that, the group analyzed which compound of H. schizopetalus affected 11 protein targets by Pyrx with the highest binding affinity. PNLIP has the highest binding affinity compared to other proteins, so the group analyzed this PNLIP protein with its relationship to obesity. The group found that three proteins that work on PNLIP are beta-sitosterol, kaempferol, and gallocatechin gallate. After docking these three proteins, the group found only one active compound has the highest binding affinity compared to the commercial drug Orlistat. Then, the process ended by performing MDs of the active compound as a candidate drug for anti-obesity. In this study, the group found that gallocatechin gallate, as an active compound of H. schizopetalus, can inhibit PNLIP enzymes for obesity therapy by bio-informatics study.
... Pada bunga terdiri dari senyawa antosianin yaitu sianidin-3-glukosida, selain itu terdapat hidrokarbon tersaturasi diantaranya 15−34 karbon, metil ester dari asam lemak, α-tokoferol dan fitosterol (S. K. Wong et al., 2016). ...
The mangrove plant (Hibiscus tiliaceus L.) is widely cultivated in tropical regions such as Indonesia because almost all parts of plant are believed to provide many benefits. Som of the benefits of the mangrove plant include laxative, treating earache, antibacterial, and antioxidant. The aim of the research is to analyze the content of phytochemical compounds contained in the mangrove plant and its antioxidant activity. This research uses a journal review method based on data collection carried out by inclusion and exclusion obtained from the google scholar, science direct, taylor and francis, garuda, and sage publication data search engine, including textbooks and scientific articles published above year of 2013. The result of the research is the phytochemical compounds found in mangrove plant are anthocyanin compounds, amides, coumarins, phenols, organic acids and flavonoid compounds that identified in the leaves, stems, and bark in mangrove plants uses several of solvents, there are methanol water, chloroform, and ethanol. The part of the plant that has antioxidant activity is the leaves which has strong antioxidant activity (IC50 = 86,5 µg/mL).
... Chemical constituents of H. schizopetalus include anthocyanins and triterpene esters (Wong & al., 2016) with pharmacological properties of antioxidant (Wong & al., 2009(Wong & al., & 2010, analgesic & antipyretic (Zahid & al., 2012), anti-inflammatory (Pal & al., 2011), hypoglycaemic and hypolipidemic al. 2014), antiviral andantibacterial (El-Shiekh & activities. Cyanidin 3-sophoroside is the major anthocyanin in the flowers (Lowry, 1976). ...
The 'Know Your Plant' section provides us information on 'Spider Hibiscus' [Hibiscus schizopetalus (Dyer) Hook.f.], its etymology, distribution, ecology, chromosome number, phytochemistry and uses.
... Indeed, ferulic acid derivatives obtained from different Hibiscus species showed important pharmacological properties such as antiviral and angiotensin-converting enzyme inhibitory activities [43,44]. In addition, ferulic acid was described as an active molecule in H. mutabilis, H. taiwanensis extracts [45,46], and in H. sabdariffa calyx extracts [28,38]. ...
The use of plant extracts in skin-care cosmetics is a modern trend due to their richness in polyphenols that act as anti-aging molecules. Hibiscus roseus is a perennial species naturalized in Italy, with beautiful soft pink flowers; its phenolic composition and biological activities have not been studied yet. The aim of this study was to characterize and quantify the phenolics and to evaluate the antioxidant, sun protection factor (SPF), and anti-collagenase activities of the ethanolic extracts of H. roseus leaves (HL) and flowers (HF). p-Coumaric, chlorogenic, and trans-ferulic acids derivatives as well as quercetin and kaempferol flavonoids were the main phenolic compounds detected. Catechin, epicatechin, kaempferol-3-O-rutinoside, kaempferol-3-O-glucoside, kaempferol-7-O-glucoside, tiliroside, oenin, and peonidin-3-O-glucoside were detected only in HF, while phloridzin was exclusive from HL, which also showed greater amounts of hydroxycinnamic acid derivatives. HF was richer in flavonoids and total phenolics, also exhibiting greater antioxidant capacity. The SPF and anti-collagenase activity of both extracts were similar and comparable to those of synthetic standards. The overall results demonstrate that H. roseus extracts are promising sources of bioactive phenolic compounds that could be potentially applied as anti-aging agents in skin-care cosmetics.
... In this study, the Bu-F showed the highest antioxidant activity followed by the Et-E and the DCM-F; all three had significantly higher antioxidant activities compared with the ascorbic acid control. The work of Wong et al. on the leaves and flowers of H. schizopetalus showed mixed results, with unimpressive antioxidant values when using total phenolic content (TPC) and free radical scavenging (FRS), but better values when using ferrous ion chelating ability and lipid peroxidation inhibition [7]. This ambiguity might be due to the lack of proper controls (no ascorbic acid control or any other controls) and/or the difference in anthocyanin content. ...
Hibiscus schizopetalus (Dyer) Hook.f. (Malvaceae) is an ornamental plant. The aim was to investigate its antimicrobial and antioxidant activities. In vitro antiviral, antibacterial, and antioxidant activities of the 70% ethanolic extract (Et-E) of the aerial parts of the plant were determined. The Dichloromethane Fraction (DCM-F) and the n-Butanol Fraction (Bu-F) were assessed using Liquid chromatography–mass spectrometry (LC-MS). The DCM-F showed higher antiviral activities against Coxsackie B4 (CoxB4) viruses (IC50 = 64.13 µg/mL) and adenoviruses (IC50 = 54.88 µg/mL) than acyclovir (IC50 = 72.79 µg/mL for CoxB4 viruses; IC50 = 91.92 µg/mL for adenoviruses). The DCM-F showed higher anti-helicobacter pylori activity (MIC = 3.9 µg/mL) than clarithromycin (MIC = 1.95 µg/mL). The DCM-F inhibited Herpes Simplex Virus (HSV) Type I (IC50 = 29.85 µg/mL) and HSV Type II (IC50 = 74.17 µg/mL). The Bu-F showed higher anti-mycobacterial activity (MIC = 7.81 µg/mL) than isoniazid (MIC = 0.24 µg/mL) and higher antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA)(MIC = 7.81 µg/mL) than vancomycin (MIC = 3.9 µg/mL). Antioxidant assays included total antioxidant capacity (TAC), 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS), 2,2-diphenyl-1-picryl-hydrazyl (DPPH), and iron reducing power. The Bu-F showed the highest antioxidant activity. Chemical profiles were analyzed using HPLC-HR–ESI–MS to identify the metabolites responsible for these biological activities. We identified more than 60 metabolites that belong to anthocyanins, flavonoids, phenolics, terpenes, sterols, and fatty acids. In conclusion, Hibiscusschizopetalus is endowed with metabolites that could be used against viruses and antibiotic-resistant bacteria. They can also be potent antioxidants.
Objective
We aimed to examine the potential protective effects of Iraqi H. tiliaceus L . chloroform leaves extract on DEN-induced HCC in male Wistar Albino rats.
Method
Rats were assigned to four groups, six in each group. Group I: rats were administered a daily oral dose of 1 mL/kg/day of distilled water. Group II: rats were intraperitoneally injected with 70 mg/kg DEN once per week for 10 consecutive weeks. Group III: rats received 250 mg/kg of chloroform leaves extract. Groups IV: the rats were administered 500 mg/kg of chloroform leaves extract, along with their food, for five days per week over 20 weeks, with a subsequent dose of DEN once per week for 10 consecutive weeks.
Results
The results indicate that the extract demonstrated a significant reduction (p<0.05) in oxidative stress, pro-inflammatory mediators, and HCC parameters, the extract also had a beneficial effect on liver function tests, and there was a significant elevation (p<0.05) of antioxidant parameters in a dose-dependent manner.
Conclusion
This study supports the protective properties of the chloroform extract of Iraqi H. tiliaceus L . leaves in HCC.
