Figure 2 - uploaded by Issam Al Jajeh
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First conjunctival biopsy with atypical secondary acquired melanosis. A) Squamous epithelium manifesting atypical, predominantly basal, pigmented melanocytic proliferation (Hematoxylin/Eosin X200) B) Proliferating pigmented cells are positive with melanocyte marker HMB45 (X200) C) Proliferating pigmented cells are positive with melanocyte marker S100 (X200).
Source publication
Xeroderma pigmentosum (XP) is a rare genetic disease associated with hypersensitivity to ultraviolet radiation resulting in cutaneous, ocular and neurological abnormalities. Ocular involvement typically includes photophobia, keratitis, corneal opacity and atrophy of the eyelids, along with carcinomas and melanomas. We report a rare case of conjunct...
Contexts in source publication
Context 1
... examination showed actinic keratosis ( Figure 1C) and atypical secondary acquired melanosis (Figure 2A-2C). Post- operative recovery was uneventful. ...
Context 2
... the first conjunctival biopsy showed hyperplastic squamous epithelium with hyperkeratosis and basal cell atypia in basal zone ( Figure 1C) as well as atypical secondary acquired melanosis. The latter manifested as proliferation of mildly atypical pigmented cells predominantly in basal zone (Figure 2A). Proliferating cells showed expected reactions with melanocytic markers HMB45 and S100 ( Figures 2B and 2C). ...
