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Final pathology revealed a T1a gallbladder intramucosal adenocarcinoma with extensive highgrade dysplasia, lamina propria invasion, but sparing the submucosa and muscularis propria.
Source publication
Patient: Female, 55
Final Diagnosis: Gallbladder adenocarcinoma
Symptoms: Abdominal pain
Medication: —
Clinical Procedure: Cholecystectomy • pancreatic necrosectomy
Specialty: Surgery
Objective
Rare co-existance of disease or pathology
Background
Gallstones are a common cause of acute pancreatitis. The proposed mechanism by which choledocholithia...
Context in source publication
Context 1
... were no intraluminal gallstones, biliary sludge, or clots identified. Final pathology revealed a T1a gallbladder intramucosal adenocarcinoma with extensive high-grade dysplasia, lamina propria invasion, but sparing the submucosa and muscularis propria (T1a) (Figure 4). The cystic duct margin and radial/circumferential margin were negative for tumor [6]. ...
Similar publications
Acute pancreatitis represents a disorder characterized by acute necroinflammatory changes of the pancreas and is histologically characterized by acinar cell destruction. Diagnosed clinically with the Revised Atlanta Criteria, and with alcohol and cholelithiasis/choledocholithiasis as the two most prominent antecedents, acute pancreatitis ranks firs...
Citations
... There are usually 70% found by accident in routine cholecystectomy specimens. There are many occasional GC surgeries that give the impression of benign disease, mainly gallstones and cholecystitis [3,4]. Because of its rarity, despite the progress of hepatobiliary imaging technology, most of them are in the late stage of diagnosis. ...
Objective:
To investigate the expressions of Formin-like 2 (FMNL2) and Cortactin (CTTN) in gallbladder adenocarcinoma (GBAC) and their associations with the clinicopathological characteristics of the patients.
Methods:
The expressions of FMNL2 and CTTN were detected with immunohistochemistry (Max Vision) in 105 GBAC tissues and 40 normal gallbladder tissues.
Results:
The positive expression rates of FMNL2 and CTTN in normal gallbladder tissues were 25% and 20%, different from the positive expression rates of 84.76% and 86.67% in GBAC tissues (P < 0.001). The positive expression rate of FMNL2 and CTTN in GBAC correlated with tumor differentiation, tumor-node-metastasis (TNM), lymph node metastasis (LNM), and distant metastasis. FMNL2 expression was positively correlated with CTTN expression. Kaplan-Meier analysis showed that the overall survival time of patients with positive expressions group of FMNL2 and CTTN was significantly shorter than that of the negative expression group. Cox multivariate analysis showed that TNM, LNM, distant metastasis, and positive expression of FMNL2 and CTTN were independent factors influencing the prognosis of patients with GBAC (P < 0.05).
Conclusion:
The positive expression of FMNL2 and CTTN in GBAC is significantly increased, which may be related to the occurrence and development of GBAC. The combined detection of FMNL2 and CTTN may provide a scientific theoretical basis for the early diagnosis of GBAC, the development of new antitumor drugs, and the search for new targets of biotherapy.
