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Figure1: RNA structure: (a) primary structure, which is the nucleotide sequence of the RNA; (b) The secondary structure, which is the folded RNA that forms upon intra-strand base pairing. (c) The tertiary structure, which is the threedimensional RNA that forms upon higher-order interactions among the base-paired regions (P1, P2, etc.) (Lehman, N., 2010).
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The prediction of RNA structure is useful for understanding evolution for both in silico and in vitro studies. Physical methods like
NMR studies to predict RNA secondary structure are expensive and difficult. Computational RNA secondary structure prediction
is easier. Comparative sequence analysis provides the best solution. But secondary structu...
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... Of course, there are many questions that remain to be answered (Ray et al., 2013). We now have significantly better structure prediction tools for RNA (Ahmad et al., 2013) and the ability to determine protein binding within the context of relevant RNA 3-D structures (Schroder, Levitt, & Brunger, 2010). ...
In the 1980's, the study of localized maternal mRNAs was just emerging as a new research area. Classic embryological studies had linked the inheritance of cytoplasmic domains with specific cell lineages, but the underlying molecular nature of these putative determinants remained a mystery. The model system Xenopus would play a pivotal role in the progress of this new field. In fact, the first localized maternal mRNA to be identified and cloned from any organism was Xenopus vg1, a TGF-beta family member. This seminal finding opened the door to many subsequent studies focused on how RNAs are localized and what functions they had in development. Xenopus remains the model of choice for studies on dissecting RNA/protein transport particles and RNA-sequencing analyses that are moving the field into the future. This article is protected by copyright. All rights reserved.
