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Figure. Survival after radical nephrectomy or partial nephrectomy for renal cell carcinoma 4 cm (n = 102).
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Greater availability and utilization of modern radiological imaging modalities have resulted in an increase in the incidental discovery of renal cell carcinoma. Such tumours tend to be smaller than their symptomatic counterparts and may potentially be adequately treated using nephron-sparing surgery.
A retrospective review of all patients who were...
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Citations
Objective:
MDCT protocol optimization for renal cell carcinoma requires attention to several data acquisition, reconstruction, and display parameters. Specifically, multiple acquisitions with varying coverage, careful timing of each contrast-enhanced phase, and use of 2D and 3D multiplanar displays are required. This article reviews these parameters, supplemented by experience-based pearls and pitfalls.
Conclusion:
Proper data acquisition and utilization of postprocessing tools are essential to avoid missed diagnoses or misinterpretation when imaging renal cell carcinoma.
Of all the malignant tumors, 3.5% correspond to renal cell carcinoma and its mortality rate is near 40%. The overall survival rate for localized renal tumors is of 90% at 5 years and 82% at 10 years and the incidence raises 2% to 2.5% per year. Between 60% and 70% of new cases, the RCC are asymptomatic and incidental. The surveillance of renal masses smaller than 4 cm is accepted as an active process that requires to focus on human and administrative resources to give to the patient the best therapeutical option. This is the reason why the small renal masses (less than 4 cm) with defined characteristics can benefit of the active surveillance. El carcinoma de células renales corresponde al 3.5% de de todos los tumores malignos y tiene una mortalidad cercana al 40%. La tasa de sobrevida relativa para tumores localizados en el riñón es del 90% a los 5 años y de 82% a los 10 años y la incidencia de aumenta a una tasa de 2% a 2,5% por año. Entre 60% y 70% de los nuevos casos de CCR diagnosticados son asintomáticos y de descubrimiento incidental. La observación de masas renales menores de 4 cm de diámetro es aceptada en pacientes como un proceso activo que requiere la focalización del recurso humano y administrativo, con una inversión económica importante, para dar a estos pacientes la mejor opción terapéutica según su condición. Por esta razón los pacientes con masas renales pequeñas (<4cm.) con características definidas, pueden beneficiarse en algún momento de la observación activa teniendo en cuenta que durante el seguimiento se pueden encontrar diferentes resultados y de acuerdo a estos cambiar la observación por otra opción terapeútica.
Bei fehlender Chemotherapie- und Strahlensensibilität stellt die Operation derzeit die einzige kurative Therapie des Nierenzellkarzinoms (NZK) dar. Dabei konnte die organerhaltende Nierentumorexstirpation sich in den letzten Jahren auch bei elektiven Indikationsstellungen zunehmend etablieren und gilt bei kleinen organbegrenzten NZK inzwischen als Methode der Wahl, auch wenn über Effektivität und Sicherheit hinsichtlich Tumorkontrolle und Patientenüberleben weiterhin diskutiert wird. Die radikale Tumornephrektomie bleibt den fortgeschrittenen Tumorstadien vorbehalten. Retrospektiv zeigt sich, dass nur dann gleichwertige onkologische Ergebnisse bei der organerhaltenden Nierentumorchirurgie im Vergleich zur radikalen Nephrektomie erzielt werden können, wenn präoperativ die Selektion eines geeigneten Patientenkollektivs erfolgt. Welche Parameter hierbei vorwiegend entscheidend waren, wurde anhand unseres Patientengutes (auch im Vergleich mit aktuellen Literaturdaten) ausgewertet. Gerade bei elektiven Fällen ist nicht zuletzt durch das Fehlen objektiver Kriterien die Grenze zwischen radikaler Tumornephrektomie und organerhaltender Nierentumorexstirpation fliessend. Oftmals ist hier im Rahmen der präoperativen Analyse eine multifaktorielle Einschätzung des einzelnen Patienten erforderlich. Besonders im Fokus stand bei der Auswertung die präoperative bildgebende Diagnostik, der bei der Indikationsstellung zugunsten einer radikalen Nephrektomie respektive einer nierenerhaltenden Tumorentfernung eine entscheidende Rolle zukommt. Ziel dieser Dissertation war es zu beurteilen, ob die präoperative Diagnostik als sichere Grundlage bei der Entscheidung der Operationstechnik gesehen werden kann und welche Nachteile aus onkologischer als auch nephrologischer Sicht jeweils bei organerhaltender Nierentumorexstirpation und radikaler Tumornephrektomie resultieren.
As in other malignant tumors, prognosis in renal cell carcinoma (RCC) depends on tumor extent and metastasis at the time of primary diagnosis. Staging systems formalize the way in which the extent of RCC is being described and classified. Primary staging of RCC aims at evaluating surgical options. Since surgical excision, which is the mainstay of therapy in non-metastatic RCC, and, recently, minimally invasive ablation methods have evolved significantly over the last decades, staging systems continue to evolve along the way. The 40-year-old Robson classification has been replaced with the TNM classification of RCC, because the latter adapts more easily to changing patterns of diagnosis and therapy. Modern cross-sectional imaging methods, such as multidetector-row computed tomography (MDCT), and magnetic resonance imaging (MRI), perform highly in T-staging of local tumor extent and M-staging of distant metastasis. However, both MDCT and MRI perform poorly in N-staging of lymphadenopathy. At present, 18-F-desoxy-glucose positron emission tomography (FDG-PET) appears to be unreliable in the detection of RCC and its metastasis. This overview of current radiological and surgical literature attempts to describe how modern staging systems for RCC are organized, and which radiological and surgical developments currently influence the way in which primary staging and prognosis of RCC depend on one another.
Laparoscopic partial nephrectomy (LPN) is less morbid than open partial nephrectomy (OPN), but the high cost of new technologies used in LPN may make this a significantly more expensive procedure. In this study, the overall costs of OPN and LPN were compared using data extracted from the literature, and a series of sensitivity analyses were performed to determine the impact of individual cost components on overall cost.
Data on operating room (OR) time, equipment use, and length of stay (LOS) were abstracted after a comprehensive literature review of LPN and OPN. Decision tree models were devised to estimate the cost of each treatment using the DATA program (TreeAge software 3.5). LPN model assumptions included one that used all reusable equipment, all disposable equipment, and a hand-assist model. One and two-way sensitivity analyses were performed to evaluate the effect of individual treatment variables on overall cost.
The literature yielded 12 OPN and 13 LPN articles, comprising a total of 574 and 949 patients, respectively. The weighted mean LOS were 5.7 and 2.9 days (<0.001); average tumor sizes were 3.2 cm and 2.5 cm (P = 0.016); and the weighted mean OR times were 184 and 187 minutes for OPN and LPN (P = 0.7), respectively. The LPN model using all disposable equipment is less costly than OPN by $431 ($8450 v $8019). The slight cost superiority of the laparoscopic approach was driven by shorter LOS. One-way sensitivity analyses showed that LPN is less costly if the OR time of LPN is less than 146 minutes; LOS after LPN is less than 4.6 days; or LPN OR supply costs are less than $1670. Two-way sensitivity analyses demonstrated the effects of modifying OR time, LOS, and surgical equipment on the cost-equivalence of LPN and OPN.
Laparoscopic partial nephrectomy can be cost equivalent to the open approach in managing small renal masses if the OR time, LOS, and equipment costs are closely monitored. The high cost of new technologies can be offset by shorter LOS and decrease in OR time.
