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Figure R-34. Perivascular macrophages recruitment into the brain parenchyma after NA injection. Perivascular macrophages were identified by immunohistochemistry with CD206/mannose receptor. WT (A, C) and CCR2 -/-(B, D) mice, either injected with saline (A, B) or NA (C, D) were studied. Images show the septofimbrial area, with magnified details of some CD206 positive cells in insets. CD206 positive cells in septofimbrial nucleus were counted (F). Bars represent the mean + SD of n= 3 saline injected, and n= 4 NA injected animals. ANOVA revealed the absence of differences between groups. SF = septofimbrial nucleus.
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It is widely accepted that neuroinflammation is sometimes a process prior to the development of neurodegenerative diseases and that microglia play a key role in its development. In particular, neurological complications have been described after infections generated by pathogens that contain neuraminidase (NA) in their structure, such as the influe...
