Figure B.3: Confusion matrix of parameter recovery.

Figure B.3: Confusion matrix of parameter recovery.

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Background: Selective serotonin reuptake inhibitors (SSRIs) are first-line pharmacological treatments for depression and anxiety. However, little is known about how pharmacological action is related to cognitive and affective processes. Here, we examine whether specific reinforcement learning processes mediate the treatment effects of SSRIs. Metho...

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Context 1
... preregistered hypotheses were not supported (Table 2): there was no evidence that the aversive Pavlovian inhibition was affected by sertraline (Fig. 3A&B); that aversive Pavlovian inhibition was related to anxiety symptoms; that the baseline aversive Pavlovian bias was predictive of treatment response; that the appetitive Pavlovian bias was associated with depression or that the reward sensitivity was related to anhedonia. Table 1: This table shows baseline characteristics for ...
Context 2
... sets of results in the exploratory analyses are noteworthy. The first relates to early change in the aversive Pavlovian bias. The slope of the aversive Pavlovian bias between baseline and week 2 was positively related to depressive symptoms at week 12 (log-transformed PHQ9 total Fig. 3E). In the sertraline group, the early change was different from zero (t =2 .74, p =0 .007), whereas the later change was not (t = −0.32, p =0 .75). In contrast, in the placebo group, the early change did not differ from zero (t = −0.70, p =0.483), but the late change did (t =3 .44, p<0.001). Hence, the group difference in the late ...
Context 3
... Materials Findings in the Whole Sample). Figure 3: Effects of Sertraline on RL Parameters. A) shows the aversive Pavlovian bias at baseline and at the follow-ups separated into drug groups (blue,left=placebo; red,right=sertraline). ...

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Background Selective serotonin reuptake inhibitors (SSRIs) are first-line pharmacological treatments for depression and anxiety. However, little is known about how pharmacological action is related to cognitive and affective processes. Here, we examine whether specific reinforcement learning processes mediate the treatment effects of SSRIs. Method...