Fig 3 - uploaded by Mouzaki Athanasia
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A schematic overview of the de novo and the salvage pathways for the biosynthesis of nucleic acids. Mycophenolic mofetil (MMF) is converted in vivo to Mycophenolic Acid (MPA), which inhibits the enzyme inosine monosphate dehydrogenase (IMPDH) which catalyzes the conversion of inosine-5-phosphate (IMP) to GMP. IMPDH is the rate limiting enzyme of the de novo pathway of purine synthesis; since lymphocytes rely predominantly on this pathway, MMF effects are largely confined to this cellular population without significant effects on the phagocytic and bactericidal activity of neutrophils. PRPP: 5-phosphoribosyl-1-phosphate
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Hyper activation of the immune system has emerged as an important clinical marker of HIV disease progression to AIDS. During the chronic phase of the disease, chronic immune activation is linked to systemic CD4 T-cell depletion and eventual immune failure. Additionally, the HIV virus per se seems to engage in a form of molecular parasitism for host...
