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Platelet and fibrin-rich orthobiologic products, such as autologous platelet concentrates, have been extensively studied and appreciated for their beneficial effects in multiple conditions. PRP and its derivatives, including PRF, have demonstrated encouraging outcomes in clinical and laboratory settings, particularly in the treatment of musculoskel...
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... fibrin clot that is formed between the PPP and erythrocytes layers is what makes PRF such an interesting orthobiologic tool. It entraps platelets, leukocytes, and growth factors, thus becoming a natural and autologous bioscaffold ( figure 2) and a rich reservoir of bioactive molecules for tissue regeneration [76][77][78]. PRF can then be easily removed and collected from the tube with a forceps for further applications. ...
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... Platelet-Rich Fibrin (PRF) is composed of a fibrin matrix polymerized in a tetramolecular arrangement, with the integration of platelets, leucocytes, cytokines, and circulating stem cells. [10]. A novel PRF preparation, known as advanced PRF (A-PRF), was developed in 2014 by lowering the centrifugation force (g) to 100 g for 14 minutes, and A-PRF produced greater growth factors, proliferation, and cell migration of fibroblasts [11]. ...
LATELET RICH FIBRIN (PRF) is a biological and innovative therapeutic which has important role in regenerative injured tissue. The aims of this study were to prepare lyophilized-PRF and determine its applications during wound healing, depending on histopathological and immunohistochemistry parameters. Six healthy, adult local breed dogs were used, the animals were randomly divided into 2 experimental main groups (treated and control) 6 animals for each group, ten ml of whole blood was aspirated from the same animal for platelet rich fibrin preparation and centrifugation of this fresh blood at 3000 rpm for 10 minutes was performed, the resulted PRF layer was removed to prepare lyophilized PRF by freezing and was stored at −80C∘ then the sample was freeze-dried for 12 hours by using Labconco lyophilizer at −51C∘ Surgical full thickness incision wound of 5cm length was performed under general anesthesia on back of dogs under aseptic technique, treated group Lyophilized A-PRF (Right side) was applied subcutaneously while normal saline 0.9% was applied instead of Lyophilized A-PRF in the control group (Left side). The wound was closed using surgical silk suture. The histological criteria for wound healing, inflammatory cell infiltration, re-epithelialization, and granulation tissue formation were evaluated according to the scoring system (0-4), Furthermore, the results of quantitative analysis of immunohistochemistry of PDGF expression showed that the group treated with Lyph-PRF was moderate, intense and mild cytoplasmic staining reactivity on the first, third and seventh days respectively after PO compared to the control.
Bioproducts derived from platelets have been extensively used across various medical fields, with a recent notable surge in their application in dermatology and aesthetic procedures. These products, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), play crucial roles in inducing blood vessel proliferation through growth factors derived from peripheral blood. PRP and PRF, in particular, facilitate fibrin polymerization, creating a robust structure that serves as a reservoir for numerous growth factors. These factors contribute to tissue regeneration by promoting cell proliferation, differentiation, and migration and collagen/elastin production. Aesthetic medicine harnesses these effects for diverse purposes, including hair restoration, scar treatment, striae management, and wound healing. Furthermore, these biological products can act as adjuvants with other treatment modalities, such as laser therapy, radiofrequency, and microneedling. This review synthesizes the existing evidence, offering insights into the applications and benefits of biological products in aesthetic medicine.
