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Background:
Sesame oil and rice bran oil are known for their unsaturated fatty acids and antioxidants contents and have been reported to reduce the cardiovascular risk.
Objective:
To determine the effect of a blend of 20% unrefined cold-pressed lignans-rich sesame oil and 80% physically refined γ-oryzanol-rich rice bran oil (Vivo) as cooking oil...
Contexts in source publication
Context 1
... shown in Figure 1, the hypertensives and normotensives were then assigned to groups as (1) normotensives treated with sesame oil blend (n 5 100), (2) hypertensives treated with sesame oil blend (n 5 100), (3) hypertensives treated with nifedipine (n 5 100), a known antihypertensive calcium channel blocker drug (20 mg/d), and (4) hypertensives receiving the combination of sesame oil blend and nifedipine (20 mg/d; n 5 100). The normotensive and hypertensive groups except the nifedi- pine alone-treated hypertensive group were supplied with the unsaturated and antioxidants-rich sesame oil blend (Table 1) 4 to 5 liters for a 4-to 5-member family/month, and they were instructed to use the oil blend as the only source of cooking oil in place of other edible oils for 60 days. The participants were generally using palm oil, sunflower oil, mustard oil, sesame oil, and soya been oil at random before their enrollment into this study. ...
Context 2
... magnitude of blood pressure reduction by the use of sesame oil blend (median reduction: SBP, -20 mm Hg; DBP, -12 mm Hg; MAP, -16 mm Hg) mimics the antihypertensive action of nifedi- pine (median reduction: SBP, -17 mm Hg; DBP, -11 mm Hg; MAP, -14 mm Hg) as noted from our study, which clearly indicated that using sesame oil blend alone has the potential effect in controlling high blood pressure, and also, the sesame oil blend showed additive effects with nifedipine for a remarkable and highly exceptional blood pressure- lowering effect (median reduction: SBP, -38 mm Hg; DBP, -24 mm Hg; MAP, -29 mm Hg). Blend of sesame oil and rice bran oil is composed of antioxidant lignans (0.3%), total tocopherols (50 mg/100g), and g-oryzanol (0.8%), followed by the abundance availability of unsaturated fatty acids, mainly oleic acid and linoleic acid (Table 1). Indeed, the anti- oxidant lignans and g-oryzanol itself may also have induced marked and significant reductions in blood pressure, although it is unlikely that the unsaturated fatty acids alone are responsible for the blood pressure-lowering effects of sesame oil and rice bran oil blend. ...
Context 3
... shown in Figure 1, the hypertensives and normotensives were then assigned to groups as (1) normotensives treated with sesame oil blend (n 5 100), (2) hypertensives treated with sesame oil blend (n 5 100), (3) hypertensives treated with nifedipine (n 5 100), a known antihypertensive calcium channel blocker drug (20 mg/d), and (4) hypertensives receiving the combination of sesame oil blend and nifedipine (20 mg/d; n 5 100). The normotensive and hypertensive groups except the nifedipine alone-treated hypertensive group were supplied with the unsaturated and antioxidants-rich sesame oil blend (Table 1) 4 to 5 liters for a 4-to 5-member family/month, and they were instructed to use the oil blend as the only source of cooking oil in place of other edible oils for 60 days. The participants were generally using palm oil, sunflower oil, mustard oil, sesame oil, and soya been oil at random before their enrollment into this study. ...
Context 4
... magnitude of blood pressure reduction by the use of sesame oil blend (median reduction: SBP, -20 mm Hg; DBP, -12 mm Hg; MAP, -16 mm Hg) mimics the antihypertensive action of nifedipine (median reduction: SBP, -17 mm Hg; DBP, -11 mm Hg; MAP, -14 mm Hg) as noted from our study, which clearly indicated that using sesame oil blend alone has the potential effect in controlling high blood pressure, and also, the sesame oil blend showed additive effects with nifedipine for a remarkable and highly exceptional blood pressurelowering effect (median reduction: SBP, -38 mm Hg; DBP, -24 mm Hg; MAP, -29 mm Hg). Blend of sesame oil and rice bran oil is composed of antioxidant lignans (0.3%), total tocopherols (50 mg/100g), and g-oryzanol (0.8%), followed by the abundance availability of unsaturated fatty acids, mainly oleic acid and linoleic acid (Table 1). Indeed, the antioxidant lignans and g-oryzanol itself may also have induced marked and significant reductions in blood pressure, although it is unlikely that the unsaturated fatty acids alone are responsible for the blood pressure-lowering effects of sesame oil and rice bran oil blend. ...
Similar publications
Objectives:
Rice bran oil (RBO) is a major source of monounsaturated fatty acid and gamma-oryzanol, which may assist in lowering blood lipids and oxidative stress. This study examined the effects of RBO containing different amounts of gamma-oryzanol on blood lipid, antioxidant, and inflammatory markers.
Materials and methods:
A total of 59 hyper...
Citations
... One more issue is the fair percentage of ω-6, ω-3 and ω-9 FAs. Table 2 enlists the recent studies on nutritional impacts, health benefits, and outcomes of physiochemical changes of blending oils/fats [2,33,[51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68]. ...
... The ratio selected for the blend was 20% SSO and 80% RBO and used as cooking oil for hypertensive patients for 60 days. The effect was recorded that the blend offered a significant reduction in blood pressure, total cholesterol, LDL cholesterol, non-high-density lipoprotein cholesterol, and TAG levels while HDL cholesterol levels increased significantly in hypertensive patients [56]. ...
... Oleic and linoleic acids are essential for growth, physiological function, and body maintenance. In addition, rice bran oil can be used as a cooking oil due to its potential to reduce the risk of cholesterol-related heart disease (Oluremi et al. 2013;Devarajan et al. 2016). Although rice bran oil still contains palmitic acid as a saturated fatty acid, its content is still much lower when compared to palm oil (44.5%) (Oluremi et al. 2013). ...
This research aimed to stabilize rice bran to reduce enzymatic reactions and optimize rice bran oil extraction using ultrasound-assisted extraction (UAE). The optimization was performed using response surface methodology (RSM). The results showed that rice bran oil has three primary fatty acids (oleic, linoleic, palmitic). Stabilization of rice bran using an autoclave (121 °C) for 10 min was recommended, with oil yield (14.2%), free fatty acid/FFA (0.41%), and gamma oryzanol (16.1 ppm). The storage significantly affected oil yield and gamma oryzanol but not FFA (p>0.05). The untreated and stabilized rice bran FFA during 18-day storage ranged from 1.33 to 5.73% and 0.41 to 1.12%. This confirmed that stabilization could inactivate lipase enzymes by reducing FFA. The optimization showed that the linear model best explained oil yield, total phenol content (TPC), and antioxidant activity (IC50), while the 2FI model was best fitted for gamma oryzanol. The optimal condition was found for UAE extraction at an amplitude of 90% and a time of 30 min. Verifying optimal conditions resulted in oil yield (13.6%), TPC (44.8 mg GAE/g), IC50 (207.2 ppm), and gamma oryzanol (15.8 ppm). Further in-depth studies are required to investigate using green solvents in the UAE and gamma oryzanol purification.
... Sesame seeds have different colours including white, buff, tan, gold, brown, reddish, gray, and black. The seeds are small, their size, form, and colors vary with the thousands of varieties and the seed coat may be smooth or ribbed (Devarajan et al., 2016). It is consumed directly as sweetmeat, a "peanut butter-like" product, a candy ingredient, bread condiments, and snack foods. ...
The chemical composition and in vitro properties of hexane and methanol extract of Sesamum indicum seeds (SIS) obtained from Kogi State, Nigeria were evaluated. The proximate analysis of the ground seed showed the presence of moisture content (8.56 ± 0.02%), dry matter (91.44 ± 0.02%), ash content (5.70 ± 0.01%), crude protein (19.37 ± 0.08%), crude fiber (6.34 ± 0.03%), fat (52.77 ± 0.02%) and carbohydrates (7.26 ± 0.14%). Phytochemical analysis of both extracts showed the presence of oxalate, hydro cyanide, alkaloids, tannins, total flavonoids, phenol, steroids and terpenes. Flavonoids and phenol contents were higher in both extracts. The flavonoid and phenol concentrations of hexane and methanol extracts were 24.79 ± 0.01 and 25.27 ± 0.02 mg/100 g, 24.32 ± 0.02 mg/100 g and 18.66 ± 0.04 mg/100g, respectively. Hydrogen cyanide was found in lowest concentration in both extracts. Vitamins analysis showed that vitamin E had the highest composite for hexane and methanol extract. Vitamin E concentration was 3.44 ± 0.01 mg/100g and 2.95± 0.02mg/100g respectively while vitamin B6 (0.01 ± 0.00 mg/100g) and vitamin B1 (0.03 ± 0.00 mg/100g) were found in lowest concentration respectively. The mineral analysis showed that potassium (43.33 ± 0.04 and 27.46 ± 0.02 mg/100g) had the highest concentration for methanol and hexane extract, respectively. The results of the DPPH activity of methanol and hexane extract of S. indicum seeds indicated that the activity of the extract were all significantly (p<0.05) lower than the values for ascorbic acid (standard) across all concentrations. However, the DPPH activity of hexane extract indicated that there was no activity in the tested concentrations below100 µg/mL. The result of the FRAP of methanol and hexane extract of SIS showed that there was no activity at the concentrations of 100 µg/ml and 400 µg/ml respectively. However, the activity observed at concentrations above 100 µg/ml and 400 µg/ml were all significantly (p<0.05) lower than the same concentration in ascorbic acid. This result implies that hexane and methanol extract of S. indicum seeds possess nutritional and pharmacological value and can be a rich source of minerals, vitamins and antioxidative supplement.
... Sesame seeds have different colours including white, buff, tan, gold, brown, reddish, gray, and black. The seeds are small, their size, form, and colors vary with the thousands of varieties and the seed coat may be smooth or ribbed (Devarajan et al., 2016). It is consumed directly as sweetmeat, a "peanut butter-like" product, a candy ingredient, bread condiments, and snack foods. ...
The chemical composition and in vitro properties of hexane and methanol extract of Sesamum indicum seeds (SIS) obtained from Kogi State, Nigeria were evaluated. The proximate analysis of the ground seed showed the presence of moisture content (8.56 ± 0.02%), dry matter (91.44 ± 0.02%), ash content (5.70 ± 0.01%), crude protein (19.37 ± 0.08%), crude fiber (6.34 ± 0.03%), fat (52.77 ± 0.02%) and carbohydrates (7.26 ± 0.14%). Phytochemical analysis of both extracts showed the presence of oxalate, hydro cyanide, alkaloids, tannins, total flavonoids, phenol, steroids and terpenes. Flavonoids and phenol contents were higher in both extracts. The flavonoid and phenol concentrations of hexane and methanol extracts were 24.79 ± 0.01 and 25.27 ± 0.02 mg/100 g, 24.32 ± 0.02 mg/100 g and 18.66 ± 0.04 mg/100g, respectively. Hydrogen cyanide was found in lowest concentration in both extracts. Vitamins analysis showed that vitamin E had the highest composite for hexane and methanol extract. Vitamin E concentration was 3.44 ± 0.01 mg/100g and 2.95± 0.02mg/100g respectively while vitamin B6 (0.01 ± 0.00 mg/100g) and vitamin B1 (0.03 ± 0.00 mg/100g) were found in lowest concentration respectively. The mineral analysis showed that potassium (43.33 ± 0.04 and 27.46 ± 0.02 mg/100g) had the highest concentration for methanol and hexane extract, respectively. The results of the DPPH activity of methanol and hexane extract of S. indicum seeds indicated that the activity of the extract were all significantly (p<0.05) lower than the values for ascorbic acid (standard) across all concentrations. However, the DPPH activity of hexane extract indicated that there was no activity in the tested concentrations below100 µg/mL. The result of the FRAP of methanol and hexane extract of SIS showed that there was no activity at the concentrations of 100 µg/ml and 400 µg/ml respectively. However, the activity observed at concentrations above 100 µg/ml and 400 µg/ml were all significantly (p<0.05) lower than the same concentration in ascorbic acid. This result implies that hexane and methanol extract of S. indicum seeds possess nutritional and pharmacological value and can be a rich source of minerals, vitamins and antioxidative supplement.
... The sample size for this study was calculated based on the difference between two means. Devarajan et al. (2016) reported that the mean systolic BP (SBP) in patients with hypertension was reduced by 15 mmHg 1 month after supplementation with sesame oil mixed with rice bran oil (RBO), with a standard deviation of 17 mmHg. With an alpha error of 0.05, a beta error of 0.20, and the power of the test of 0.80, the sample size for this study was 16 per group, for a total of 20 participants, including a plausible 20% dropout proportion. ...
... Each participant received either 1,000 mg/d of RBO or RRBO, 500 mg×2 capsules, 30 min after breakfast daily for 8 weeks. The duration and dosage of supplementation were considered based on previous reports in patients with mild-to-moderate hypertension and type 2 diabetes (Lai et al., 2012;Devarajan et al., 2016) and the availability of the study supplements. The primary outcomes were changes in oxidative stress and cardiovascular risk biomarkers. ...
We investigated the changes in the oxidative stress and cardiovascular disease risk biomarkers, including the activity of the cardiac autonomic nervous system, in older adults with prehypertension following Riceberry rice bran oil supplementation. A total of 35 women aged 60 to 76 years with prehypertension were randomly allocated to two groups, one of which was supplemented with rice bran oil (n=18) and the other with Riceberry rice bran oil (n=17) at 1,000 mg daily for 8 weeks. Prior to and after the supplementation, oxidative stress and cardiovascular risk biomarkers (primary outcomes), heart rate variability, and blood pressure (secondary outcomes) were investigated. Results showed that plasma malondialdehyde, blood glutathione disulfide, and tumor necrosis factor-alpha levels were significantly decreased, and the ratio of reduced glutathione to glutathione disulfide significantly increased in both groups after supplementation (all P<0.05). No significant differences were observed between groups. Heart rate variability and blood pressure did not statistically significantly change subsequent to supplementation in either group and did not differ between groups. In conclusion, Riceberry rice bran oil supplementation for 8 weeks alleviates oxidative stress and inflammation in older adults with prehypertension to a similar extent as rice bran oil supplementation.
... The highest linoleic acid content was (30.54%) in A1 sample, while, the minimum oil content was observed B3 sesame seed oil (27.49%). This result is in agreement with Devarajan et al, (2016). The highest content of Linolenic acid observed in A1sesame oil part of Sh sample was (0.51%), whereas lowest Linolenic content was noticed in B3 sesame oil (0.35). ...
This study was conducted to determine the main physiochemical properties of sesame oil extracted from three sesame seeds samples, the differences between mixed (A-C) and the sieved sesame seed (A1-C3): which were taken from Sharzoor in Sulaymaniyah (S, mixed brown), Akre in Duhok (A, mixed brown) and Mala Omar in Hawler (MO, mixed brown). And to evaluate the differences between the OIL characteristics of mixed (Akre ,A, Sharzoor B, Mala Omar ,C) and the sieved seeds with three different mesh size sieve (1.50, 1.35, 1) mm included (A1,A2,A3,.B1,B2,B3 ,C1,C2 and C3). The properties that included to study in this work were viscosity, specific gravity, fatty acid content, acid value, iodine value, and peroxide value. From the results of this study, it was found that the Mala Omar sample in all parts especially C2 48.42% is considered good source for oil, the viscosity of (hawler) samples especially C3 with 0.0490 Pas, the lowest viscosity while the A1 has a maximum viscosity 0.0525 Pas. More than 80% of sesame seeds' fatty acid composition is unsaturated, with high concentrations of oleic, linoleic, and lenolinic acids. Saturated fatty acids, primarily palmitic and stearic acids, account for the remaining 20%. Acid value in sample A1 of sharazoor sesame oil had the lowest content (2.1030 mg KoH\gm oil), whereas sample C3 had the greatest concentration. Omar Mala 15.5815. A3 sharazoor sample a higher 11.4954 gm I2\100gm oil, iodine value. While the maximum peroxide value was found in the B3 sesame oil sample of 15.9267 meq/kg, and the lowest peroxide value was found in the B sesame oil sample at 3.8850 meq/kg.
... Plants can be used for the management of LDL cholesterol such as beans, 54-56 soluble dietary fiber, 57 pulses, 58 high-selenium lentil, 59 Brassica oleracea, cabbage 60 and Aronia melanocarpa fruit juice. 61 Fish oil, 62 sunflower oil, 63 high-oleic canola oil, 64 a blend of sesame oil and rice bran oil (20:80), 65 sesame oil 66 reduce cardiovascular risk. 67 ...
Cardiovascular disease (CVD) is the one of major global health issues with approximately 30% of the mortality reported in the mid-income population. Low-density lipoprotein (LDL) plays a crucial role in development of CVD. High LDL along with others forms a plaque and blocks arteries, resulting in CVD. The present chapter deals with the mechanism of receptor-mediated endocytosis of LDL and its management by drugs such as statins and PCSK9 inhibitors along with dietary supplementation for health improvements.
... Previous clinical studies have shown that rice bran reduces SBP when combined with other interventions such as energy restriction or the administration of sesame oil [27,28]. This is the first study to show that a rice bran-based food material alone can reduce blood pressure without being combined with another intervention. ...
The anti-hypertensive effect of processed rice bran (PRB) was recently reported, for which the novel peptide Leu-Arg-Ala (LRA) was identified as the functional substance. The purpose of this study was to assess the anti-hypertensive effects of a rice bran supplement containing PRB in individuals with high-normal blood pressure (systolic blood pressure (SBP): 130-139 mmHg and/or diastolic blood pressure (DBP): 85-89 mmHg) or grade 1 hypertension (SBP: 140-159 mmHg and/or DBP: 90-99 mmHg). One hundred individuals with high-normal blood pressure or grade 1 hypertension were recruited to participate in this double-blind, randomized, placebo-controlled study. Participants were randomly allocated to the placebo group (n = 50) or the test group (n = 50). Each group took four test tablets (43 µg LRA/day) or four placebo tablets daily. The decrease in blood pressure in the test group compared with the placebo group was the primary outcome. Adverse events were recorded and hematological/urinary parameters measured to determine the safety of the supplement, which was the secondary outcome. In total, 87 participants completed the study. The SBP of the test group at 12 weeks was significantly lower than that of the placebo group (p = 0.0497). No serious adverse events were observed. Daily consumption of a rice bran supplement containing PRB can safely improve mildly elevated blood pressure.
... The demand for emulsified meat products has increased rapidly in recent years, and certain parts of the globe have enjoyed consumer acceptance (Kang et al., 2014;Devarajan et al., 2015). Traditional emulsified meat products contain a high fat content (>25%) to ensure appealing texture and flavour (Kang et al., 2017;Jeon et al., 2015). ...
... It has a high polyunsaturated fat content, abundant lignan compounds, and α-tocopherol. The intake of sesame oil is associated with a decreased risk of hypertension and cardiovascular disease (Devarajan et al., 2015;Wu et al., 2009). Moreover, sesamolin, sesamol and α-tocopherol have antioxidant activities and are very stable against deterioration by oxidation; therefore, sesame oil is an ideal animal fat substitute for reduced-fat meat products (Wan et al., 2015;Shao et al., 2020). ...
In this study, the changes in emulsion stability, colour, textural properties, and protein secondary structure of reduced-fat pork batters (50% pork back-fat and 50% pre-emulsified sesame oil) treated under different pressures (0.1, 200 and 400 MPa) were investigated. The emulsion stability, cooking yield, L* value, texture properties, initial relaxation times of T2b, T21, and T22, and peak ratios of P21 in the samples treated under 200 and 400 MPa significantly increased (p < 0.05) compared with those at 0.1 MPa, but the a* and b* values, and the peak ratio of P22 significantly decreased (p < 0.05). The sample treated at 200 MPa exhibited the best emulsion stability, textural properties, water-holding capacity and sensory scores among the samples. High-pressure processing induced structural changes from α-helical to β-sheet, β-turn, and random coil structures, enhancing protein-water incorporation and lowering water mobility. High-pressure processing and pre-emulsified sesame oil improved the techno-functional properties and emulsion stability of reduced-fat pork batters.
... Overall, they detected that high white rice consumption might be a risk factor for metabolic syndrome development [87]. In contrast, a combination of sesame oil and RBO exerted significant antihypertensive and lipidlowering activity and reduced the blood pressure, LDL-C, TG, and non-HDL-C levels, and elevated the HDL-C levels [88]. Interestingly, rice bran enzymatic extract (RBEE) has been shown to reduce hypertension linked to obesity in a dose-dependent manner. ...
Alpha-bisabolol (α-bisabolol), an unsaturated monocyclic sesquiterpene alcohol, is known as one of the "most-used herbal constituents" in the world. Various therapeutic and biological properties of α-bisabolol in preventing oxidative stress, inflammatory disorders, infections, neurodegenerative diseases, cancers, and metabolic disorders have been reported. In this review, we evaluated new findings regarding the molecular mechanisms of α-bisabolol published from 2010 until 2021 in PubMed, Science Direct, and Scopus. The antioxidant mechanism of α-bisabolol is mainly associated with the reduction of ROS/RNS, MDA, and GSH depletion, MPO activity, and augmentation of SOD and CAT. Additionally, upregulating the expression of bcl-2 and suppression of bax, P53, APAF-1, caspase-3, and caspase-9 activity indicates the anti-apoptotic effects of α- bisabolol. It possesses anti-inflammatory effects via reduction of TNF-α, IL-1β, IL-6, iNOS, and COX-2 and suppresses the activation of ERK1/2, JNK, NF-κB, and p38. The antimicrobial effect is mediated by inhibiting the viability of infected cells and improves cognitive function via downregulation of bax, cleaved caspases-3 and 9 levels, β-secretase, cholinesterase activities, and upregulation of bcl-2 levels. Finally, due to multiple biological activities, α-bisabolol is worthy to be subjected to clinical trials to achieve new insights into its beneficial effects on human health.
