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FTIR spectra of 5-FU, pure PLGA, and 5-FU–PLGNPs prepared by double emulsion technique for F525, F125 and F225, respectively
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Nanoscale devices offer a lot of potential in drug delivery because of their small size. The goal of this work was to increase the oral bioavailability of the anti-cancer hydrophilic drug as 5-fluorouracil (5-FU) by incorporating it into poly (D, L-lactide-co-glycolide) nanoparticles (PLGNPs) using the double emulsion process, 5-FU- PLGNPs nanopart...
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Targeted drug delivery to cancer cells utilizing antibodies against oncogenic cell-surface receptors is an emerging therapeutical approach. Here, we developed a computational framework to evaluate the treatment efficacy of free Doxorubicin (Dox) and immunoliposome at different stages of vascular solid tumors. Firstly, three stages of vascularized t...
Citations
... Coating with polysorbate80 enhances the uptake of nanoparticles encapsulating various drugs by brain tissue as compared to the control group of uncoated nanoparticles. 19,20 At the moment we speculate that the coating of nanoparticles with polysorbate80 leads to the specific alteration of the surface properties. 16 This new surface then seems to adsorb certain substances from blood that, in turn, induce endocytotic uptake by brain endothelial cells. ...
5-Fluorouracil (5-FU) has become one of the most widely employed antimetabolite chemotherapeutic agents in the treatment of several cancers including brain, colorectal, breast, head and neck, pancreas and stomach cancers. The variability in 5-FU pharmacokinetics makes oral dosing impractical due to low and unpredictable bioavailability. Carmofur or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a lypophilic-masked analogue of 5-FU. We present studies on encapsulation of HCFU into the nanogels synthesized through copolymerization of N-isopropylacrylamide (NIPAAM) and N-vinylpyrrolidone (VP) having hydrophobic core and hydrophilic shell by cross-linking with N, N’methylenebisacrylamide. This enables easy entrapment and retention of HCFU inside the hydrophobic core of the nanoparticles. A comparison of the therapeutic efficacies and cell sustainability of 5-fluorouracil, HCFU, HCFU loaded nanogels and unencapsulated nanogels as studied in BMG-1 Cells, is reported. URN:NBN:sciencein.cbl.2024.v11.655
... Thus, confirming the crystalline nature of the drug. 34 The intense peaks were greatly diffused and their intensity has been reduced to a great extent, hence indicating the encapsulation of the drug in cubosomes. Few less intense peaks could be due to the presence of some un-entrapped drug molecules that might be present on the surface (Figure 6). ...
... It is clear that the DSC thermogram of 5-Fluorouracil shows a single sharp endothermic peak at 280-285°C, which is related to a study reported previously. 34,[39][40][41] GMO and poloxamer have shown endotherms at around 30-35 and 55-60°C. Furthermore, the thermogram of 5-Fluorouracil loaded cubosomes has shown a border peak between 30-60°C, that night has shown the presence of both GMO and poloxamer, however, the sharp characteristic endotherm 5-FU has been converted into a broader peak, confirming that drug now, has been captured by the cubosomes of GMO, assisted by poloxamer 407. ...
Featured Application: This review explores an innovative approach to combating resistance to breast cancer through the application of nanotechnology. Abstract: Breast cancer (BC) ranks among the most diagnosed solid tumors worldwide. For decades, significant research efforts have been dedicated to finding selective treatments for these solid tumors. Currently, the primary treatment method for BC involves surgery, with the subsequent utilization of radiotherapy and chemotherapy. However, these subsequent treatments often fall short of effectively treating BC due to their side effects and harm to healthy tissues. Today, a range of nano-particles are being developed to target BC cells without affecting the surrounding healthy tissues. This in-depth review, based on studies, seeks to shed light on these specially designed nanoparticles and their potential in BC treatment. Typically, therapeutic drugs or naturally occurring bioactive compounds are incorporated into precisely crafted nanoparticles. This enhances their solubility, longevity in the bloodstream, and distribution in the body while also minimizing side effects and immune reactions. Nanoparticles have been designed to address the shortcomings of standalone therapeutics and traverse various biological obstacles spanning the systemic, microenvironmental, and cellular that differ among patients and diseases. We prioritize breakthroughs in nanoparticle design to surpass diverse delivery obstacles and believe that smart nanoparticle engineering not only enhances effectiveness for general delivery but also allows customized solutions for specific needs, ultimately leading to better outcomes for patients.
The electrospinning process was used to successfully encapsulate an anticancer drug, 5-fluorouracil (5-FU), into poly(ε-caprolactone)/gelatin (Gel) nanofiber mats (5-FU-PCL/Gel NFs). Nanofibers are recognized to be potential carriers for the delivery of anticancer drugs. One of the safest solvent systems for making PCL/Gel NF mats is the formic acid/acetic acid (FA/AA) solvent system. A compound solution jet was drawn from a customized coaxial spinneret using a high potential electric field of 20 kV. The loading of 5-FU with three different concentrations (5, 10, and 15 wt.%) improved PCL stabilization in the FA/AA system. The miscibility of the blended polymers in the electrospun nanofibers mats and 5-FU being well distributed in the nanofiber matrix was investigated using X-ray diffraction (XRD). In vitro 5-FU release from electrospun PCL/Gel NF mats revealed sustained release from the nanofiber mats, whereas slower release was found when higher concentrations of 5-FU were used. The produced electrospun PCL/Gel NF mats were studied by SEM, FTIR, TGA, and DSC. According to a study on drug release kinetics, 5-FU was released from PCl/Gel NFs in a diffusion-controlled pattern.
