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FT-IR spectra of p-Cl-benzaldehyde in percent of Fe3O4, MIL-101(Cr)-NH2, MIL-101(Cr)-N(CH2PO3H2)2 and Fe3O4@MIL-101(Cr)-N(CH2PO3).
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![Preparation of novel mono and bis and tris pyrazolo[3,4-b] pyridine...](publication/362795901/figure/fig2/AS:11431281079966488@1660964199188/Preparation-of-novel-mono-and-bis-and-tris-pyrazolo3-4-b-pyridine-using_Q320.jpg)
In this study, a novel nano-magnetic metal–organic frameworks based on Fe3O4 namely Fe3O4@MIL-101(Cr)-N(CH2PO3)2 was synthesized and fully characterized. The prepared sample was used as catalyst in the synthesis of pyrazolo [3,4-b] pyridines as convenient medicine by condensation reaction of aldehydes, 5-(1H-Indol-3-yl)- 2H-pyrazol-3-ylamine and 3-...
Citations
... Tasked-specific design of porous catalysts has been our main research interest in recent years [40][41][42][43][44][45][46][47][48][49][50][51] . Functionalizing suitable substrates for the synthesis of efficient catalysts is one of the most important ways to improve catalytic abilities. ...
The strategy of designing heterogeneous porous catalysts by a post-modification method is a smart strategy to increase the catalytic power of desired catalysts. Accordingly, in this report, metal-organic frameworks based on titanium with acetic acid pending were designed and synthesized via post-modification method. The structure of the target catalyst has been investigated using different techniques such as FT-IR, XRD, SEM, EDX, Mapping, and N2 adsorption/desorption (BET/the BJH) the correctness of its formation has been proven. The catalytic application of Ti-based MOFs functionalized with acetic acid was evaluated in the preparation of new spiropyrans, and the obtained results show that the catalytic performance is improved by this modification. The strategy of designing heterogeneous porous catalysts through post-modification methods presents a sophisticated approach to enhancing the catalytic efficacy of desired catalysts. In this context, our study focuses on the synthesis and characterization of metal-organic frameworks (MOFs) based on titanium, functionalized with acetic acid pendants, using a post-modification method. Various characterization techniques, including Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), mapping, and N2 adsorption/desorption (BET/BJH), were employed to investigate the structure and composition of the synthesized catalyst. These techniques collectively confirmed the successful formation and structural integrity of the target catalyst. The structure of the synthesized products was confirmed by melting point, ¹H-NMR and ¹³C-NMR and FT-IR techniques. Examining the general process of catalyst synthesis and its catalytic application shows that the mentioned modification is very useful for catalytic purposes. The presented catalyst was used in synthesis of a wide range of biologically active spiropyrans with good yields. The simultaneous presence of several biologically active cores in the synthesized products will highlight the biological properties of these compounds. The present study offers a promising insight into the rational design, synthesis, and application of task-specific porous catalysts, particularly in the context of synthesizing biologically active candidate molecules.
... The peak at 2500 cm −1 is attributed to the stretching vibration of the S-H bond [30]. The peak at 2923 cm −1 is related to the asymmetric stretching C-H bond [31,32]. The peaks at 1380 and 1652 cm −1 are corresponded to the C-N and C = N bonds, respectively [33,34]. ...
A novel magnetic nanocomposite modified with a new branched polymer containing nitrogen-rich ligand moieties was synthesized and used to stabilize Pd nanoparticles. The resulting catalyst was characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, scanning electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, vibrating sample magnetometry, thermogravimetric analysis and energy-dispersive X-ray. The synthesized catalyst has been applied as an efficient catalyst in the reduction of nitro compounds to corresponding amines and reductive degradation of organic dyes such as methyl orange and methyl red. The catalyst showed high stability and reusability for 10 runs without significant loss in catalytic activity.
Graphical abstract
... Donor and receiver groups that coexist in a proper molecule can make acceptor groups work the axial position of the anomeric carbon [66], it happens with catalyst reactions too, according to Fig. 4. The stereoelectronic effect decides the last step of the reaction Catalysts can be tested for preparing novel compounds [67]. ...
The anomeric effect in carbohydrate chemistry is known as the interaction between the OHd substituent at the anomeric position to favor an axial orientation rather than an equatorial one, despite the increased 1,3-diaxial interactions. In the anomeric effect, a sugar ring is stabilized by an electronegative substituent at the C1 carbon, also known as the anomeric carbon. The stabilization is thought to result from interactions between lone electron pairs on oxygen and a C1 antibonding orbital. On the other hand, the anomeric effect can be of two types: endo-anomeric and exo-anomeric. The effect is called endo-anomeric when the lone pair comes from the oxygen atom in the sugar ring and exo-anomeric when the lone pair comes from oxygen in a substituent on C1. Several factors influence the anomeric effect. In this way, this review aims to describe the recent advances in main theories, observations, and advances achieved in the last decades related to the anomeric effect. GRAPHICAL ABSTRACT
... Fe 3 O 4 -derived novel catalyst namely Fe 3 O 4 @MIL-101(Cr)-N(CH 2 PO 3 ) 2 (59) was successfully applied as a catalyst for the preparation of medicinally significant novel pyrazolo [3,4-b]pyridines 63 [48]. Three-component condensation among aldehydes 60, 5-(1H-indol-3-yl)-2H-pyrazol-3-ylamine 61, and 3-(cyanoacetyl)indole 62 in the presence of this catalyst 59 without solvent at 100°C gave pyrazolo[3,4-b]pyridines in high yields (Scheme 15). ...
Multidrug-resistant (MDR) pathogens have created a fatal problem for human health and antimicrobial treatment. Among the currently available antibiotics, many are inactive against MDR pathogens. In this context, heterocyclic compounds/drugs play a vital role. Thus, it is very much essential to explore new research to combat the issue. Of the available nitrogen-bearing heterocyclic compounds/drugs, pyridine derivatives are of special interest due to their solubility. Encouragingly, some of the newly synthesized pyridine compounds/drugs are found to inhibit multidrug-resistant S. aureus (MRSA). Pyridine scaffold bearing poor basicity generally improves water solubility in pharmaceutically potential molecules and has led to the discovery of numerous broad-spectrum therapeutic agents. Keeping these in mind, we have reviewed the chemistry, recent synthetic techniques, and bacterial preventative activity of pyridine derivatives since 2015. This will facilitate the development of pyridine-based novel antibiotic/drug design in the near future as a versatile scaffold with limited side effects for the next-generation therapeutics.
... Then, a mixture of Fe 3 O 4 MNPs and MIL-101(Cr)-N(CH 2 PO 3 H 2 ) 2 was dispersed in toluene at 80 °C for 12 h. After cooling the reaction mixture, the nanoporous MMOF composite (Fe 3 O 4 @MIL-101(Cr)-N(CH 2 PO 3 ) 2 ) was collected by an external bar magnet, washed with ethanol, and dried before catalytic application (Sepehrmansourie et al. 2022). ...
Developing a novel, simple, and cost-effective analytical technique with high enrichment capacity and selectivity is crucial for environmental monitoring and remediation. Metal–organic frameworks (MOFs) are porous coordination polymers that are self-assembly synthesized from organic linkers and inorganic metal ions/metal clusters. Magnetic metal–organic framework (MMOF) composites are promising candidate among the new-generation sorbent materials available for magnetic solid-phase extraction (MSPE) of environmental contaminants due to their superparamagnetism properties, high crystallinity, permanent porosity, ultrahigh specific surface area, adaptable pore shape/sizes, tunable functionality, designable framework topology, rapid and ultrahigh adsorption capacity, and reusability. In this review, we focus on recent scientific progress in the removal of heavy metal ions present in contaminated aquatic system by using MMOF composites. Different types of MMOFs, their synthetic approaches, and various properties that are harnessed for removal of heavy metal ions from contaminated water are discussed briefly. Adsorption mechanisms involved, adsorption capacity, and regeneration of the MMOF sorbents as well as recovery of heavy metal ions adsorbed that are reported in the last ten years have been discussed in this review. Moreover, particular prospects, challenges, and opportunities in future development of MMOFs towards their greener synthetic approaches for their practical industrial applications have critically been considered in this review.
Graphical abstract
... In recent years, multicomponent reactions (MCRs) have been considered as an efficient synthetic method for the preparation of various compounds. [19][20][21][22][23] In other words, multi-component reactions are one of the goals of many research studies because many drug and biological compounds are prepared by performing multi-component reaction. 24,25 Indole compounds are an important group of heterocycle compounds that have received much attention due to their unique properties. ...
Herein, we introduced a new method for the synthesis of bis(3-indolyl)pyridines. Accordingly, ammonium acetate was introduced as a dual reagent-catalyst role, for preparation of bis(3-indolyl)pyridines without using any toxic solvents and co-catalysts. Also, the cooperative vinylogous anomeric based oxidation (CVABO) theory plays a synergistic effect for the aromatization of final product. The final structure of products has been verified using FT-IR and ¹H-NMR, ¹³C-NMR techniques.
Herein, we designed and synthesized a new H-bond magnetic catalyst with 2-tosyl-N-(3-(triethoxysilyl)propyl)hydrazine-1-carboxamide as a sensitive H-bond donor/acceptor. We created an organic structure with a urea moiety on the magnetic nanoparticles, which can function as a hydrogen bond catalyst. Hydrogen bond catalysts serve as multi-donor/-acceptor sites. Additionally, we utilized magnetic nanoparticles in the production of the target catalyst, giving it the ability to be recycled and easily separated from the reaction medium with an external magnet. We evaluated the catalytic application of Fe3O4@SiO2@tosyl-carboxamide as a new magnetic H-bond catalyst in the synthesis of new nicotinonitrile compounds through a multicomponent reaction under solvent-free and green conditions with high yields (50–73%). We confirmed the structure of Fe3O4@SiO2@tosyl-carboxamide using various techniques. In addition, the structures of the desired nicotinonitriles were confirmed using melting point, ¹H-NMR, ¹³C-NMR and HR-mass spectrometry analysis. The final step of the reaction mechanism was preceded via cooperative vinylogous anomeric-based oxidation (CVABO).
