Figure - available from: Frontiers in Veterinary Science
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Magnetic resonance imaging signs in human amyotrophic lateral sclerosis (ALS). Magnetic resonance imaging (MRI) from two amyotrophic lateral sclerosis (ALS) patients with the “motor band sign,” i.e., motor cortex hypointensities, on susceptibility weighted imaging [SWI, (A, D)] and T2 hyperintensities along the corticospinal tract on 3T 3D T2w-FLAIR (B, C, E, F). Image adjusted from (20). For comparison, T2 signal changes in rodent brain stem motor nuclei are shown in (21–23).
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Background and objectives
Animal models for motor neuron diseases (MND) such as amyotrophic lateral sclerosis (ALS) are commonly used in preclinical research. However, it is insufficiently understood how much findings from these model systems can be translated to humans. Thus, we aimed at systematically assessing the translational value of MND anim...
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Amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, is a motor neuron disease. In ALS, upper and lower motor neurons in the brain and spinal cord progressively degenerate during the course of the disease, leading to the loss of the voluntary movement of the arms and legs. Since its first description in 1869 by a French neurologist Jean-Ma...
