Figure 4
Expression of immune indicators in angiolymphoid hyperplasia with eosinophilia. The proliferative blood vessels strongly express CD31, ERG and SMA immune markers, while the surrounding matrix is characterized by a large number of CD68-expressing histiocytes and some CD138-expressing plasma cells. The proliferative lymphocytes mainly express the T-cell marker CD3 and a small amount of CD20. The proliferation marker Ki-67 shows lower expression in the tumor itself and higher expression in inflammatory regions (scale bars, 50 µm; 15 µm in the magnified windows). ERG, ETS-related gene; SMA, smooth muscle actin.
Source publication
Angiolymphoid hyperplasia with eosinophilia (ALHE), a rare benign proliferative tumor, mainly occurs in several countries in Asia and it is characterized by true vascular branching hyperplasia with infiltration of a large number of lymphocytes and eosinophils in the stroma. The present case report analyzed the clinical symptoms and fine-needle aspi...
Contexts in source publication
Context 1
... addition, immunohistochemical staining was performed to determine the expression of specific proteins using the corresponding antibodies (Fig. 4). Fresh tumor tissues were soaked in 4% neutral formaldehyde at 37˚C for 24 h and then dehydrated with different concentrations of alcohol and paraffin-embedded. Adhesion slides with 4-µm sections were kept at 60˚C for 4 h. Thereafter, the slides were deparaffinized with xylene and hydrated with an ethanol gradient. Subsequently, the ...
Context 2
... lesion tissue contained several tissue cells expressing CD68 and a small number of plasma cells expressing CD138. Immunohistochemical staining for the proliferation marker Ki-67 revealed that the tumor itself was in a low proliferative state. By contrast, the inflammatory cells in the peripheral stroma exhibited strong proliferation (Fig. ...
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