Figure 1 - uploaded by Einar Birnir Ólafsson
Content may be subject to copyright.
Download
View publication
Expression of GABA-A receptor subunit mRNAs in PBMCs from blood of (a) men (n = 16), (b) non-pregnant women (n = 19), (c) healthy pregnant women (n = 27) and (d) depressed pregnant women (n = 15). The mRNA level of each subunit was normalized to reference genes TBP and IPO8 and presented as mean AESEM.

Expression of GABA-A receptor subunit mRNAs in PBMCs from blood of (a) men (n = 16), (b) non-pregnant women (n = 19), (c) healthy pregnant women (n = 27) and (d) depressed pregnant women (n = 15). The mRNA level of each subunit was normalized to reference genes TBP and IPO8 and presented as mean AESEM.

Source publication
Cite
Download full-text

Contexts in source publication

Context 1
... average expression levels of the different GABA-A receptor subunits are shown in Figure 1 for men (Fig. 1a), non-pregnant women (Fig. 1b), healthy pregnant women (Fig. 1c) and depressed pregnant women (Fig. 1d). The number of individuals express- ing each subunit is given in Table 1. ...
Context 2
... average expression levels of the different GABA-A receptor subunits are shown in Figure 1 for men (Fig. 1a), non-pregnant women (Fig. 1b), healthy pregnant women (Fig. 1c) and depressed pregnant women (Fig. 1d). The number of individuals express- ing each subunit is given in Table 1. Eleven GABA-A receptor subunits were detected in PBMCs from men (Fig. 1a, n = 16), and nine of these were present in three or more individuals (Table 1). The ...
Context 3
... average expression levels of the different GABA-A receptor subunits are shown in Figure 1 for men (Fig. 1a), non-pregnant women (Fig. 1b), healthy pregnant women (Fig. 1c) and depressed pregnant women (Fig. 1d). The number of individuals express- ing each subunit is given in Table 1. Eleven GABA-A receptor subunits were detected in PBMCs from men (Fig. 1a, n = 16), and nine of these were present in three or more individuals (Table 1). The non-pregnant women (n = 19), ...
Context 4
... average expression levels of the different GABA-A receptor subunits are shown in Figure 1 for men (Fig. 1a), non-pregnant women (Fig. 1b), healthy pregnant women (Fig. 1c) and depressed pregnant women (Fig. 1d). The number of individuals express- ing each subunit is given in Table 1. Eleven GABA-A receptor subunits were detected in PBMCs from men (Fig. 1a, n = 16), and nine of these were present in three or more individuals (Table 1). The non-pregnant women (n = 19), healthy pregnant women (n = 27) and ...
Context 5
... average expression levels of the different GABA-A receptor subunits are shown in Figure 1 for men (Fig. 1a), non-pregnant women (Fig. 1b), healthy pregnant women (Fig. 1c) and depressed pregnant women (Fig. 1d). The number of individuals express- ing each subunit is given in Table 1. Eleven GABA-A receptor subunits were detected in PBMCs from men (Fig. 1a, n = 16), and nine of these were present in three or more individuals (Table 1). The non-pregnant women (n = 19), healthy pregnant women (n = 27) and depressed pregnant women (n = 15) ...
Context 6
... average expression levels of the different GABA-A receptor subunits are shown in Figure 1 for men (Fig. 1a), non-pregnant women (Fig. 1b), healthy pregnant women (Fig. 1c) and depressed pregnant women (Fig. 1d). The number of individuals express- ing each subunit is given in Table 1. Eleven GABA-A receptor subunits were detected in PBMCs from men (Fig. 1a, n = 16), and nine of these were present in three or more individuals (Table 1). The non-pregnant women (n = 19), healthy pregnant women (n = 27) and depressed pregnant women (n = 15) expressed 15, 13 and 13 different subunits respectively, and 10, nine and seven of these were expressed in three or more individuals (Fig. 1b-d, Table 1) ...
Context 7
... in PBMCs from men (Fig. 1a, n = 16), and nine of these were present in three or more individuals (Table 1). The non-pregnant women (n = 19), healthy pregnant women (n = 27) and depressed pregnant women (n = 15) expressed 15, 13 and 13 different subunits respectively, and 10, nine and seven of these were expressed in three or more individuals (Fig. 1b-d, Table 1) respectively. The q2 subunits had the most prominent expression level in all groups. Interestingly, the profile of the other expressed GABA-A subunits implies a rather selective expression of high-affinity GABA-A receptors in the PBMCs: a4, a5, a6, b1, b2, c2, d, e, q2 and q3 were expressed by all four groups. In neurons, ...
Context 8
... average expression levels of the different GABA-A receptor subunits are shown in Figure 1 for men (Fig. 1a), non-pregnant women (Fig. 1b), healthy pregnant women (Fig. 1c) and depressed pregnant women (Fig. 1d). The number of individuals expressing each subunit is given in Table 1. ...
Context 9
... average expression levels of the different GABA-A receptor subunits are shown in Figure 1 for men (Fig. 1a), non-pregnant women (Fig. 1b), healthy pregnant women (Fig. 1c) and depressed pregnant women (Fig. 1d). The number of individuals expressing each subunit is given in Table 1. Eleven GABA-A receptor subunits were detected in PBMCs from men (Fig. 1a, n = 16), and nine of these were present in three or more individuals (Table 1). The ...
Context 10
... average expression levels of the different GABA-A receptor subunits are shown in Figure 1 for men (Fig. 1a), non-pregnant women (Fig. 1b), healthy pregnant women (Fig. 1c) and depressed pregnant women (Fig. 1d). The number of individuals expressing each subunit is given in Table 1. Eleven GABA-A receptor subunits were detected in PBMCs from men (Fig. 1a, n = 16), and nine of these were present in three or more individuals (Table 1). The non-pregnant women (n = 19), ...
Context 11
... average expression levels of the different GABA-A receptor subunits are shown in Figure 1 for men (Fig. 1a), non-pregnant women (Fig. 1b), healthy pregnant women (Fig. 1c) and depressed pregnant women (Fig. 1d). The number of individuals expressing each subunit is given in Table 1. Eleven GABA-A receptor subunits were detected in PBMCs from men (Fig. 1a, n = 16), and nine of these were present in three or more individuals (Table 1). The non-pregnant women (n = 19), healthy pregnant women (n = 27) and ...
Context 12
... average expression levels of the different GABA-A receptor subunits are shown in Figure 1 for men (Fig. 1a), non-pregnant women (Fig. 1b), healthy pregnant women (Fig. 1c) and depressed pregnant women (Fig. 1d). The number of individuals expressing each subunit is given in Table 1. Eleven GABA-A receptor subunits were detected in PBMCs from men (Fig. 1a, n = 16), and nine of these were present in three or more individuals (Table 1). The non-pregnant women (n = 19), healthy pregnant women (n = 27) and depressed pregnant women (n = 15) ...
Context 13
... average expression levels of the different GABA-A receptor subunits are shown in Figure 1 for men (Fig. 1a), non-pregnant women (Fig. 1b), healthy pregnant women (Fig. 1c) and depressed pregnant women (Fig. 1d). The number of individuals expressing each subunit is given in Table 1. Eleven GABA-A receptor subunits were detected in PBMCs from men (Fig. 1a, n = 16), and nine of these were present in three or more individuals (Table 1). The non-pregnant women (n = 19), healthy pregnant women (n = 27) and depressed pregnant women (n = 15) expressed 15, 13 and 13 different subunits respectively, and 10, nine and seven of these were expressed in three or more individuals (Fig. 1b-d, Table 1) ...
Context 14
... in PBMCs from men (Fig. 1a, n = 16), and nine of these were present in three or more individuals (Table 1). The non-pregnant women (n = 19), healthy pregnant women (n = 27) and depressed pregnant women (n = 15) expressed 15, 13 and 13 different subunits respectively, and 10, nine and seven of these were expressed in three or more individuals (Fig. 1b-d, Table 1) respectively. The q2 subunits had the most prominent expression level in all groups. Interestingly, the profile of the other expressed GABA-A subunits implies a rather selective expression of high-affinity GABA-A receptors in the PBMCs: a4, a5, a6, b1, b2, c2, d, e, q2 and q3 were expressed by all four groups. In neurons, ...

Similar publications

View
Figure 5 Distribution (percentage) of patient categories by number of...
Characteristics of concurrent use (n=96 581)
Prevalence of concurrency by age group and total days of concurrency...
Characterisation of concurrent use of prescription opioids and benzodiazepine/Z-drugs in Alberta, Canada: a population-based study
Article
Full-text available
  • Sep 2019
Objective The objective of this study is to characterise concurrent use of benzodiazepine receptor modulators and opioids among prescription opioid users in Alberta in 2017. Design A population based retrospective study. Setting Alberta, Canada, in the year 2017. Participants All individuals in Alberta, Canada, with at least one dispensation rec...
View
Figure 3. Mean neuronal cell counts and densitometric measurements SEM...
Figure 4. Subunit-specific GABA A receptor immunoreactivity in the CA1...
Figure 5. Altered morphology of large multipolar interneurons...
Figure 8. Subunit-specific changes in GABA A receptor immunoreactivity...
+1
Selective Alterations in GABA A Receptor Subtypes in Human Temporal Lobe Epilepsy
Article
Full-text available
  • Jul 2000
Temporal lobe epilepsy (TLE) is associated with impaired inhibitory neurotransmission. Studies in animal models suggest that GABA A receptor dysfunction contributes to epileptogenesis. To understand the mechanisms underlying TLE in humans, it is fundamental to determine whether and how GABA A receptor subtypes are altered. Furthermore, identifying...
View
View

Citations

... Lymphocytes have a functional GABAergic system which may operate as a modulator of T-cell activation [29]. GABA-A receptor expression in human peripheral blood mononuclear cells is regulated by gender [30]. Different subtypes of T cells, CD4 and CD8, from human, rat, and mice lymph nodes have been also shown to express mRNA and protein for subunits and had functional GABA-A channels [31]. ...
Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice
Article
Full-text available
  • Sep 2015
In the present study, the possible effect of sodium valproate (NaVP) on urethane-induced lung tumors in female mice has been evaluated. BALB/c mice ( n = 60 ; 4–6 weeks old, females) were used in the following groups: (1) urethane-treated; (2) urethane-NaVP-treated; (3) only NaVP-treated; (4) control. In the same groups, ovariectomized female mice ( n = 60 ) were investigated. Urethane was given intraperitoneally, with a total dose of 50 mg/mouse. In NaVP-treated mice groups, 0.4% aqueous solution of NaVP was offered to mice ad libitum . The duration of the experiment was 6 months. The number of tumors per mouse in ovariectomized mice and in those treated with urethane and NaVP was significantly higher than in mice treated with urethane only ( 8.29 ± 0.58 versus 6.0 ± 0.63 , p < 0.02 ). No significant difference in the number of tumors per mouse was revealed while comparing the nonovariectomized urethane- and urethane-NaVP-treated groups ( p = 0.13 ). A significant decrease of adenocarcinoma number in ovariectomized mice treated with a urethane-NaVP as compared with ovariectomized mice treated with urethane only was found ( p = 0.031 ). NaVP together with low estrogen may have a protective effect on the malignization of adenomas in ovariectomized mice.
View