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Evolution of allele frequencies within families under four simulated regimes. Examples of mutational fates are given for HDHS (a), LDHS (b), HDNS (c), LDNS (d). Mutations are recorded only when occurring in one of the selected progenitors, and corresponding frequencies are computed over all selected individuals. For example under High Drift regimes, the initial frequency of a mutation occurring in any given progenitor within a family is 1 ÷ (2 × 5) as 5 diploid individuals are selected at each generation. Under Lower Drift regimes, the mutation initial frequency equals 1 ÷ (2 × 50). The dynamics of de novo mutations: Evolution of frequencies 10

Evolution of allele frequencies within families under four simulated regimes. Examples of mutational fates are given for HDHS (a), LDHS (b), HDNS (c), LDNS (d). Mutations are recorded only when occurring in one of the selected progenitors, and corresponding frequencies are computed over all selected individuals. For example under High Drift regimes, the initial frequency of a mutation occurring in any given progenitor within a family is 1 ÷ (2 × 5) as 5 diploid individuals are selected at each generation. Under Lower Drift regimes, the mutation initial frequency equals 1 ÷ (2 × 50). The dynamics of de novo mutations: Evolution of frequencies 10

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Figure 2 Frequency distribution of the Time to the Most Common Ancestor...
Figure 3 Evolution of allele frequencies within families under four...
Figure 4 Distribution of effects of incoming and fixed mutations under...
Figure 5 Violin plots of raw mutational effects according to fixation...
+6 Figure 6 Violin plots of Cov(G |selected , E |selected ) under four...
Interplay between high-drift and high-selection limits the genetic load in small selfing maize populations
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  • Dec 2020
Population and quantitative genetics provide useful approximations to predict the evolution of populations and their multilocus adaptive dynamics. They are not supposed to hold under extreme parameter combinations, for which deviations need to be further quantified to provide insights into specific population dynamics. Here we focused on small self...
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... in all cases except for the LDNS 1 selection regime (Fig. S6). The equilibrium value depended on 2 the census population size: around 6 polymorphic loci with high 3 drift (HDHS and HDNS), 40 polymorphic loci under LDHS, and 4 > 66 polymorphic loci after 20 generations under LDNS (Tab. 2c regimes strikingly differed in their mutational dynamics (Fig. ...