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Evaluation of the missing imputation accuracy value for data with imputed values (NA rate = 0.5) at checkpoint 3 (Fig. 2). a Evaluation based on the ICC. Error bars represent 95% confidence intervals. Significance levels are denoted as * for adjusted p-values < 0.05 and *** for p-values < 0.001. p-values were adjusted using the Benjamini–Hochberg method for multiple comparisons. b Evaluation by NRMSE
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Background
Extracellular vesicle-derived (EV)-miRNAs have potential to serve as biomarkers for the diagnosis of various diseases. miRNA microarrays are widely used to quantify circulating EV-miRNA levels, and the preprocessing of miRNA microarray data is critical for analytical accuracy and reliability. Thus, although microarray data have been used...
