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Objective: To evaluate the effectiveness of the application of hyperbaric oxygen therapy in Wistar rats with spinal cord contusion produced using computerized equipment to create impact by a falling weight, NYU Impactor. Methods: We evaluated 17 male rats with weights ranging from 265 to 426 g; impacts were performed with a weight of 10 g from a pr...
Contexts in source publication
Context 1
... the 2 nd postoperative day, the group not treated with hy- perbaric oxygen therapy (control group) presented an aver- age of 2.4 points on the BBB scale, while the treated group presented an average of 5.9 points on the scale. (Figure 4) On the 9 th postoperative day, the difference between the groups decreased on the motor evaluation scale, with the control group presenting 9.9 points, and the group treated with hyperbaric oxygen therapy scoring 11.9 points on the BBB scale. (Figure 5) On the 16 th postoperative day, the control group with oxygen therapy presented 12.6 points, while the group submitted to the hyperbaric chamber presented 14.4 points on the BBB scale. ...
Context 2
... study was nec- essary to make sure that the traumatism had been effective in the production of the spinal cord contusion. The locomotor capacity results, obtained by the BBB scale, of the Hyperbaric Oxygen group, were 59.3% higher than those of the Control group on the 2 nd postoperative day (Figure 4) and 20.2% higher on the 9 th day. (Figure 5) On the 16 th day the difference was not proved. ...
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Citations
... At the time of admission, the animals were evaluated the general health conditions and the acclimation period of three days was observed (GALVÃO et al., 2011). The rats were housed in individual cages lined with excelsior; with free access to water and diet; in an environment with temperature controlled by automatic adjustment (22 ºC ± 2 ºC); noise below 60 dB; humidity around 45% ± 15%; with a 12-h light-dark cycle (DAMY et al., 2010;RÊGO et al., 2010). ...
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This study reviews the literature concerning possible therapeutic approaches for spinal cord injury. Spinal cord injury is a disabling and irreversible condition that has high economic and social costs. There are both primary and secondary mechanisms of damage to the spinal cord. The primary lesion is the mechanical injury itself. The secondary lesion results from one or more biochemical and cellular processes that are triggered by the primary lesion. The frustration of health professionals in treating a severe spinal cord injury was described in 1700 BC in an Egyptian surgical papyrus that was translated by Edwin Smith; the papyrus reported spinal fractures as a ''disease that should not be treated.'' Over the last biological or pharmacological treatment method. Science is unraveling the mechanisms of cell protection and neuroregeneration, but clinically, we only provide supportive care for patients with spinal cord injuries. By combining these treatments, researchers attempt to enhance the functional recovery of patients with spinal cord injuries. Advances in the last decade have allowed us to encourage the development of experimental studies in the field of spinal cord regeneration. The combination of several therapeutic strategies should, at minimum, allow for partial functional recoveries for these patients, which could improve their quality of life.
Experimental, controlled, animal study.
To evaluate the functional effect of hyperbaric oxygen therapy administered shortly, one day after, and no intervention (control) in standardized experimental spinal cord lesions in Wistar rats.
São Paulo, Brazil.
In all, 30 Wistar rats with spinal cord lesions were divided into three groups: one group was submitted to hyperbaric oxygen therapy beginning half an hour after the lesion and with a total of 10 one-hour sessions, one session per day, at 2 atm; the second received the same treatment, but beginning on the day after the lesion; and the third received no treatment (control). The Basso, Beattie and Bresnahan scales were used for functional evaluation on the second day after the lesion and then weekly, until being killed 1 month later.
There were no significant differences between the groups in the functional analysis on the second day after the lesion. There was no functional difference comparing Groups 1 and 2 (treated shortly after or one day after) in any evaluation moment. On the 7th day, as well as on the 21st and 28th postoperative days, the evaluation showed that groups 1 and 2 performed significantly better than the control group (receiving no therapy).
Hyperbaric chamber therapy is beneficial in the functional recovery of spinal cord lesions in rats, if it is first administered just after spinal cord injury or within 24 h.
