Erythematous, flat-topped, hyperkeratotic papules on the dorsal metacarpophalangeal joints bilaterally (gottron papules).

Erythematous, flat-topped, hyperkeratotic papules on the dorsal metacarpophalangeal joints bilaterally (gottron papules).

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Relapsing polychondritis (RPC) is an uncommon autoimmune systemic disease characterized by recurrent inflammation of the cartilage tissue. It can occur alone or in association with other autoimmune diseases, vasculitis, or hematologic disorders. However, the association of RPC with dermatomyositis is extremely rare. Herein, we present a case of a 3...

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Background Anti-IgLON5 disease is a rare chronic autoimmune disorder characterized by IgLON5 autoantibodies predominantly of the IgG4 subclass. Distinct pathogenic effects were described for anti-IgLON5 IgG1 and IgG4, however, with uncertain clinical relevance. Methods IgLON5-specific IgG1-4 levels were measured in 46 sera and 20 cerebrospinal flu...