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Sarcoidosis is a multisystem granulomatous disease that may affect various organs. Nevertheless, involvement of the trigeminal nerve is exceedingly uncommon. This report presents a rare case of isolated bilateral trigeminal neuropathy presenting with neurotrophic corneal ulcers. The patient was treated with topical chloramphenicol and lubricants, a...
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Accumulated evidence from experimental animal models suggests that neuronal loss within the dorsal horn is involved in the development and/or maintenance of peripheral neuropathic pain. However, to date, no study has specifically investigated whether such neuroanatomical changes also occur at this level in humans. Using brain imaging techniques, we...
Purpose
The aim of our study was to assess, electrophysiologically, the possibility of associated subclinical trigeminal neuropathy in sickle cell anemia (SCA) patients and correlate the Results with disease severity and findings of computerized tomography.
Materials and methods
Fifty patients with SCA were included; 20 of these patients had clinic...
Citations
... Five percent of neurological manifestations have been associated with facial nerve palsy, optic neuritis and small-fibre neuropathy (125). The involvement of the trigeminal nerve has been reported, however, appears to be rare (126). The most commonly reported symptoms are unilateral, transient decreased sensation or paraesthesia in the area covered by the involved nerve (80,127). ...
... Absence of corneal sensation can result from impairment of trigeminal corneal innervation, a condition known as neurotrophic keratopathy. Gupta et al [35] reported a particularly rare case of isolated bilateral CN-V neuropathy in a patient with sarcoidosis who presented with neurotrophic corneal ulcers and was diagnosed with biopsy-proven cutaneous sarcoidosis. The patient also had decreased sensation to light touch involving all divisions of the trigeminal nerve bilaterally, with no other cranial neuropathies. ...
... The patient also had decreased sensation to light touch involving all divisions of the trigeminal nerve bilaterally, with no other cranial neuropathies. After all potential causes of CN-V neuropathy were ruled out, isolated bilateral trigeminal neuropathy as a result of sarcoidosis was the confirmed diagnosis [35] . ...
Sarcoidosis is a multisystem, chronic inflammatory disease that is characterized by the development of non-caseating granulomas in multiple body tissues and organ systems. Neurological complications of systemic sarcoidosis include peripheral and cranial neuropathies, myopathies, seizures, gait dysfunction, and cognitive decline. Because sarcoidosis has a predilection to involve the basilar meninges, cranial neuropathy is the most prevalent neurological deficit seen when the nervous system is involved. Sarcoidosis cranial neuropathy may occur at different stages of the disease and even as the initial clinical manifestation of central nervous system involvement. Attributing a cranial neuropathy MINIREVIEWS
... Our patient had a profound sensory deficit related to a mass lesion involving the gasserian ganglion. A case report of trigeminal neurosarcoidosis presenting as bilateral neurotrophic corneal ulcers has been described in a patient with cutaneous sarcoidosis [15]. ...
