Figure - available from: Scientific Reports
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Electroplating apparatus used to plate Cr metal from a CrCl3 solution where the cathode is located between the base plate and the plastic coin holder. The anode is the platinum rod which can be seen connected to the motor and suspended in the CrCl3 plating solution.
Source publication
Mn is a promising PET radiometal with a half-life of 5.6 days and an average positron energy of 242 keV. Typically, chromium of natural isotope abundance is used as a target material to produce this isotope through the nat/52 Cr(p,n) ⁵² Mn reaction. While natural Cr is a suitable target material, higher purity ⁵² Mn could be produced by transitioni...
Citations
... Manganese-52 has a long half-life of 5.6 d, sufficient positron decay branching ratio of 29.6 %, and emits positrons with a low average energy of 242 keV (0.59 mm range in water), comparable to that of 18 F (250 keV, 0.62 mm range in water) but lower than that of 89 Zr (396 keV, 1.23 mm range in water), translating to PET images with good spatial resolution [3][4][5]. Lastly, the nuclear reaction 52 Cr(p,n) 52 Mn is used to produce 52 Mn with a 12.5 MeV proton beam on target, which is widely available on many small biomedical cyclotrons [6,7]. Its main disadvantage is the emission of high-energy gamma photons (744, 936, and 1434 keV), which causes an additional dose to personnel [8]. ...
... This radiometal could be utilized in drug development to collect important information about drug kinetics, biodistribution, route of metabolization, and excretion [6]. Research on the production and purification techniques to improve the purity of this radionuclide has been reported in the literature [4,6,7,[9][10][11][12]. ...
... Manganese-52 was produced through the nuclear reaction Nat Cr(p, n) 52 Mn as previously described [6,7]. Approximately 200 mg of natural chromium powder was pressed into a 0.5 mm pellet, placed into a tantalum coin with a 0.5 mm divot, and covered with a 0.75 mm aluminum degrader. ...
