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Figure 1 - Neuronal-Specific Inhibition of Endoplasmic Reticulum Mg2+ /Ca2+ ATPase Ca2+ Uptake in a Mixed Primary Hippocampal Culture Model of Status Epilepticus

Figure 1. Electrophysiological monitoring of SE in hippocampal neurons. Culture dishes were incubated in control or low Mg 2+ solutions and neurons were patch clamped using the whole-cell current-clamp mode as described in Materials and Methods. Scale bar described in part B is applicable to all traces. (A) Representative recording of a neuron incubated in control solution. (B) Representative trace of a neuron incubated in low Mg 2+ solution for approximately 1 h. (C) Representative recording of a neuron incubated in low Mg 2+ solution for approximately 3 h.
Electrophysiological monitoring of SE in hippocampal neurons. Culture dishes were incubated in control or low Mg 2+ solutions and neurons were patch clamped using the whole-cell current-clamp mode as described in Materials and Methods. Scale bar described in part B is applicable to all traces. (A) Representative recording of a neuron incubated in control solution. (B) Representative trace of a neuron incubated in low Mg 2+ solution for approximately 1 h. (C) Representative recording of a neuron incubated in low Mg 2+ solution for approximately 3 h.
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