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Electron microscopic findings of a typical granule-containing myeloma cell. Several cytoplasmic inclusions with uniform color tone were pointed out.
Source publication
The clinical features and prognostic significance of myeloma cells containing granules remain unclear. The purpose of this retrospective study was to investigate the clinical significance of granule-containing myeloma cells in patients with newly diagnosed multiple myeloma (NDMM). We retrospectively analyzed the records of 122 patients diagnosed wi...
Context in source publication
Context 1
... the samples were negative for myeloperoxidase and periodic acid-schiff staining while four of the nine samples were positive in alpha-naphthyl acetate esterase staining. The electron microscopic findings of a GM cell from a typical patient are shown in Figure 2. In the GM group, the mean and median proportions of granule-containing myeloma cells were 29.3% and 28% (range, 10-87%), respectively. ...
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Citations
Bone marrow examination plays an important role in the diagnosis of multiple myeloma. In some cases with multiple myeloma, marrow plasma cells with cytoplasmic inclusions are seen. In this study, a 46-year-old man was evaluated for multiple myeloma. In bone marrow aspiration, large intracytoplasmic azurophilic granules, resembling intracellular microorganisms were seen. IHC study demonstrated that these cells are CD138 positive. This is a rare histologic finding that usually results from the deposition of excess immunoglobulin.
