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Effect size statistics for congestive heart failure patients reporting no other illness at entry into the study and follow- up (
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to assess the functioning and well-being of older patients presenting with congestive heart failure (CHF) using established generic health status measures-the short form 36 health survey (SF-36) and Dartmouth COOP charts.
patients aged 60 or older with CHF were asked if they would take part. They were requested to complete interviewer-administered...
Context in source publication
Context 1
... follow-up after treatment (n = 38). Table 4 reports effect sizes for this patient group, which again indicates very little change. Table 3 also includes data gained from a postal survey in West Glamorgan (Wales) in which the SF-36 was completed by people aged 65 and over who reported no chronic illness [13]. ...Citations
... In dialysis patient populations, low HRQOL scores measured utilizing the Medical Outcomes Study Short Form-36 (SF-36) were associated with hospitalization and death in studies [10][11][12][13]. There were substantial HRQOL studies conducted before in patients with kidney failure. ...
Background:
Kidney failure is a global health problem with a worldwide mean prevalence rate of 13.4%. Kidney failure remains symptomless during most of the early stages until symptoms appear in the advanced stages. Kidney failure is associated with a decrease in health-related quality of life (HRQOL), deterioration in physical and mental health, and an increased risk of cardiovascular morbidity and mortality. This study aimed to evaluate the factors associated with decreased HRQOL and other factors affecting the overall health of patients. Another objective was to measure how medication adherence and depression could affect the overall HRQOL in patients with kidney failure.
Methodology:
The study used a prospective follow-up mix methodology approach with six-month follow-ups of patients. The participants included in the study population were those with chronic kidney disease grade 4 and kidney failure. Pre-validated and translated questionnaires (Kidney Disease Quality of Life-Short Form, Hamilton Depression Rating Scale Urdu Version, and Morisky Lewis Greens Adherence Scale) and assessment tools were used to collect data.
Results:
This study recruited 314 patients after an initial assessment based on inclusion criteria. The mean age of the study population was 54.64 ± 15.33 years. There was a 47.6% male and a 52.4% female population. Hypertension and diabetes mellitus remained the most predominant comorbid condition, affecting 64.2% and 74.6% of the population, respectively. The study suggested a significant (p < 0.05) deterioration in the mental health composite score with worsening laboratory variables, particularly hematological and iron studies. Demographic variables significantly impact medication adherence. HRQOL was found to be deteriorating with a significant impact on mental health compared to physical health.
Conclusions:
Patients on maintenance dialysis for kidney failure have a significant burden of physical and mental symptoms, depression, and low HRQOL. Given the substantial and well-known declines in physical and psychological well-being among kidney failure patients receiving hemodialysis, the findings of this research imply that these areas related to health should receive special attention in the growing and expanding population of kidney failure patients.
... In our study population, all indices of health status were lower than those in ≥70year-old community-dwelling men and women without HF studied by Aaronson et al. [28], with the most pronounced differences being the domains of physical functioning, role physical and role emotional. Similar differences between patients with HF and the population at large were found in earlier studies [27,29,30]. One study performed in Russia reported on an intensive nurse-led care programme in primary care, focusing on lifestyle changes and modification of cardiovascular risk factors, exercise training and intensive proactive nursing care in 85 patients with HF-pEF. ...
Aims:
To assess whether a single training session for general practitioners (GPs) improves the evidence-based drug treatment of heart failure (HF) patients, especially of those with HF with reduced ejection fraction (HFrEF).
Methods and results:
A cluster randomised controlled trial was performed for which patients with established HF were eligible. Primary care practices (PCPs) were randomised to care-as-usual or to the intervention group in which GPs received a half-day training session on HF management. Changes in HF medication, health status, hospitalisation and survival were compared between the two groups. Fifteen PCPs with 200 HF patients were randomised to the intervention group and 15 PCPs with 198 HF patients to the control group. Mean age was 76.9 (SD 10.8) years; 52.5% were female. On average, the patients had been diagnosed with HF 3.0 (SD 3.0) years previously. In total, 204 had HFrEF and 194 HF with preserved ejection fraction (HFpEF). In participants with HFrEF, the use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers decreased in 6 months in both groups [5.2%; (95% confidence interval (CI) 2.0-10.0)] and 5.6% (95% CI 2.8-13.4)], respectively [baseline-corrected odds ratio (OR) 1.07 (95% CI 0.55-2.08)], while beta-blocker use increased in both groups by 5.2% (95% CI 2.0-10.0) and 1.1% (95% CI 0.2-6.3), respectively [baseline-corrected OR 0.82 (95% CI 0.42-1.61)]. For health status, hospitalisations or survival after 12-28 months there were no significant differences between the two groups, also not when separately analysed for HFrEF and HFpEF.
Conclusion:
A half-day training session for GPs does not improve drug treatment of HF in patients with established HF.
... The results also showed that the physical and mental scores in the elderly age group were 1.5 and 1.4 times higher than that of the adult age group, although these differences were not statistically significant. The results also showed that the QOL in the elderly age group was more disrupted than in adults with HF, which was consistent with previous studies in terms of disrupted dimensions, but it is inconsistent with previous studies regarding overall QOL scores [89][90][91]. ...
Despite various individual studies on the quality of life (QOL) in patients with CHF, a comprehensive study has not yet been conducted; therefore, this study aims to assess the QOL of CHF patients. In the present systematic review and meta-analysis, PubMed, Scopus, and the Web of science databases were searched from January 1, 2000, to December 31, 2018, using QOL and heart failure as keywords. The searches, screenings, quality assessments, and data extractions were conducted separately by two researchers. A total of 70 studies including 25,180 participants entered the final stage. The mean QOL score was 44.1 (95% confidence interval (CI) 40.6, 47.5; I² = 99.3%) using a specific random effects method in 40 studies carried out on 12,520 patients. Moreover, according to the geographical region, heart failure patients in the Americas had higher scores. In 14 studies, in which a general SF-36 survey was implemented, the average physical component score (PCS) and mental component score (MCS) were 33.3 (95% CI 31.9, 34.7; I² = 88.0%) and 50.6 (95% CI 43.8, 57.4; I² = 99.3%), respectively. The general and specific tools used in this study indicated moderate and poor QOL, respectively. Therefore, it is necessary to carry out periodic QOL measurements using appropriate tools as part of the general care of CHF patients.
... These results suggest that this questionnaire is useful for evaluating differences in health status between Mongolian subjects with normal lung function and those with ventilatory impairment. The SF-36v2 has been translated into many languages and is widely used as a multilingual questionnaire for the measurement of health status differences between normal subjects and patients with various diseases such as multiple sclerosis (Fernandez et al. 2011), rheumatoid arthritis (Matcham et al. 2014), schizophrenia (Papaioannou et al. 2011, chronic obstructive pulmonary disease (Prieto et al. 1997), cardiovascular disease (Jenkinson et al. 1997;Dempster and Donnelly 2001), and cancer (Mosconi et al. 2002). However, no Mongolian SF-36v2 has been developed to date. ...
Background
Ulaanbaatar, Mongolia, is one of the world’s worst air-polluted cities, but effects of this air pollution on the population health status have not yet been evaluated. Therefore, we developed a Mongolian version of the SF-36v2 questionnaire to investigate the health status of Mongolian population. Methods
Health checkups were conducted in Ulaanbaatar and the health status was measured using a Mongolian translated version of the SF-36v2 questionnaire. The reliability and validity of the Mongolian SF-36v2 questionnaire, and the relationship between health status and respiratory condition were examined. ResultsFactor analysis of the Mongolian SF-36v2 questionnaire showed that the “Role-physical” and “Role-emotional” were classified into a single subscale. The “Mental health” and “Vitality” were each divided into two subscales. Cronbach’s alpha and intraclass correlation coefficient (ICC) for reproducibility were >0.7, except for “General health perceptions” (Cronbach’s alpha and ICC < 0.7), “Social functioning” (Cronbach’s alpha < 0.7), and “Vitality” (ICC < 0.7). The SF-36v2 subscales and the corresponding items of the COOP/WONCA charts were correlated, and subjects with respiratory symptoms showed lower SF-36v2 scores compared to normal subjects, suggesting external validity. Subjects with respiratory symptoms showed significantly lower scores for the majority of the SF-36v2 subscales than those with normal lung function. In subjects with combined ventilatory impairment, “Physical functioning”, “Role-physical”, “Bodily pain”, and “Vitality” scores were significantly lower than those with normal lung function. Conclusions
The Mongolian version of the SF-36v2 questionnaire provides substantial reliability and validity, and is useful for evaluating the health status of Mongolian adults with ventilatory impairment. Health status measured by SF-36v2 was significantly aggravated by combined ventilatory impairment when compared with normal lung function.
... Patients with HF, the most impairment of their quality of life was in relation to the physical domain. Previous studies have reported decrease in the health related quality of life in patients with heart failure [33,34]. Juenger and colleagues found clinical symptoms of worse quality of life, defined by the SF-36 among patients with HF [35]. ...
Heart failure (HF) has an important effect on different aspects of a patient’s quality of life (QoL), including sexual function. This descriptive study was conducted in order to examine sexual dysfunction (SD) and QoL in patients with HF and evaluate factors affecting them. The sample of the study consisted of 225 married patients who admitted to a private hospital with a diagnosis of HF in the western part of Turkey between January 2011 and January 2012 and were selected according to the limitations. Data of the study was obtained by using the data sociodemographic data form, International Index of Erectile Function (IIEF), the Index of Female Sexual Function (IFSF) and the SF–36 QoL Scale. Data was analysed in the SPSS 15.0 and evaluated with descriptive statistics and the Mann Whitney U test. Most of the patients (85.3%) stated that their marital and sexual lives were affected after the diagnosis of the disease was established. The mean total score of IFSF was 27.04±3.72. The mean total score of erectile function from the subscales of the IIEF was 15.61±3.45. Sexual dysfunction was found in 81.5% of the female patients and moderate erectile dysfunction (ED) in 50.7% of the male patients. The mean scores from the subscales of SF-36 were found significantly low. It was discovered as a result of the study that QoL of patients with HF was impairment and SD was found in the majority of the female patients and ED in half of the male patients.
... приема Эгилока Ретарда отмечалось уменьшение количества баллов по Миннесотскому опроснику, свидетельствовавшее о повышении у пациентов самооценки своего состояния и восприятия своих возможностей в реальной жизни. Результаты использования опросника SF-36 свидетельствуют о том, что ограничение физической активности вносит наиболее существенный вклад в снижение качества жизни у больных старческого возраста с ХСН, что подтверждается данными других исследований [27]. ...
Aim. To study effect of cardioselective β-adrenoblocker metoprolol tartrate (in retarded formulation) on quality of life in elderly patients with chronic heart failure (CHF) of ischemic etiology.Material and methods. 78 patients with CHF class III (NYHA) were involved in the study. Patients were 81,6±0,25 y.o. in average. All patients had clinical signs of mild-to-moderate depressive disorders. Patients were split on 2 groups comparable in sex and age. Patients of the 1st group (n=43) received metoprolol tartrate (Egilok Retard), 50-100 mg/d additionally to standard therapy. Patients of the 2nd group (n=35) received only standard therapy. The somatic status was assessed before and after 1 and 3 months of therapy by clinical condition evaluated scale (CCES), 6-minute walking test, left ventricular ejection fraction (Echocardiography) as well as mental status by special tests (SMSP, BDI, Hamilton scale, C.D.Spilberger-Y.L.Hanin scale) and qualities of life (MLHFQ, SF-36).Results. Reduction of CHF class from III to II was observed in 31 (76,7%) patients of the 1st group and in 23 (65,7%) patients of the 2nd group. Tolerability of Egilok Retard was good and there were not cessations because of side effects. In 3 months of therapy severity of the somatic status according to CCES reduced more significantly in the 1st group in comparison with the 2nd group (29,5 % vs 11,5 %, p <0,001). The exercise tolerance increased higher in the 1st group comparing with the 2nd one (34 % vs 17 %, respectively, p<0,001). The severity of depression reduced (according to SMSP, Hamilton scale) more significantly in the 1st group in comparison with this in the 2nd one. Quality of life also improved more significantly in the 1st group according to MLHFQ and SF-36 (physical functions, role physical functions, social function scales) at the end of therapy.Conclusion. Metoprolol tartrate (in retarded formulation) improves somatic and mental status as well as quality of life in elderly patients with CHF.
... These scores are normalised to a general US population mean of 50 (Standard Deviation (SD) 10), scores below 50 indicate worse physical or mental health than the 'average' US population [16]. The use of these summary scores across the selected articles allowed the comparison of different conditions in populations [17][18][19][20]. ...
Population-based assessments of physical health are important to evaluate healthcare resource allocation. Normative data on the level of physical impairments attributable to specific diseases and severity levels within these diseases is critical to interpreting such data. Our objective, by means of a systematic review and meta-analysis, was to test the hypothesis that specific diseases which form cardiovascular and musculoskeletal disease spectra are associated with gradients of physical impairments. We examined a cardiovascular disease spectrum which consisted of hypertension, ischaemic heart disease and heart failure, and a musculoskeletal disease spectrum of lower back pain, osteoarthritis and rheumatoid arthritis. Using Medline, EMBASE and CINAHL databases, articles which had examined these morbidities and used either the SF-12 or SF-36 in general or primary care populations were selected; data was extracted independently by three reviewers. Study characteristics were described and the mean physical component summary scores of the SF-12 or SF-36 was analysed by disease, using random-effects meta-analysis. The association between disease and physical health (mean physical component summary scores) was assessed using multilevel meta-regression analysis, adjusting for age, health setting, country, disease definition and SF-12 or 36 format. From this search, 26 articles were identified, yielding 70 separate estimates of mean physical component summary scores across the morbidities from 14 different countries. For the selected conditions, pooled unadjusted mean physical component summary scores were: 44.4 for hypertension, 38.9 for ischaemic heart disease, 35.9 for heart failure, 39.5 for lower back pain, 36.0 for osteoarthritis and 36.5 for rheumatoid arthritis. The adjusted meta-regression showed mean physical component summary score difference for ischaemic heart disease of −4.6 (95 % confidence interval −6.0 to −3.2) and heart failure −7.5 (−9.1 to −5.9) compared to the hypertension category. For osteoarthritis −4.2 (−5.3 to −3.0) and rheumatoid arthritis −3.9 (−9.5 to 1.6) compared to the lower back pain category. Our findings provide the benchmark norms for the differences in physical health within and between disease spectra. Improved characterisation of the relative impact of individual conditions on physical health will facilitate public health assessments of chronic diseases as well as assessments of interventions using functional patient-reported outcomes.
Electronic supplementary material
The online version of this article (doi:10.1186/s12955-015-0265-x) contains supplementary material, which is available to authorized users.
... 28) Among studies of the effects of β-blockers on health-related QOL assessed by the Quality of Life Questionnaire in Severe Heart Failure and the Minnesota Living with Heart Failure Questionnaire, only a few studies reported significant improvements in QOL scores. 14) Jenkinson, et al 29) reported little difference of QOL assessed by SF-36 between before and after 4-week treatment with an ACE inhibitor in elderly patients with CHF. By contrast a sub-study of the COMPANION trial 30) showed patients treated with cardiac resynchronization therapy had a significant improvement of QOL assessed by the Minnesota Living with Heart Failure Questionnaire in association with improvements of 6MWD and NYHA functional class, as compared to those treated with optimal medical therapy. ...
... Although the SF-36 is not specific to heart failure, it covers a wide range of QOL domains and is a well-validated instrument that has been used in a number of studies with cardiac patients. 6,25,29) Although limited for these reasons, the present study indicated WT could improve mental and physical QOL in addition to improvement of cardiac and vascular endothelial function and exercise tolerance. Thus, WT could be a novel promising therapy for CHF. ...
Waon therapy (WT), which in Japanese means soothing warmth, is a repeated sauna therapy that improves cardiac and vascular endothelial function in patients with chronic heart failure (CHF). We investigated whether WT could improve the quality of life (QOL) of CHF patients in addition to improving cardiac function and exercise capacity.
A total of 49 CHF patients (69 ± 14 years old) were treated with a 60°C far infrared-ray dry sauna bath for 15 minutes and then kept in a bed covered with blankets for 30 minutes once a day for 3 weeks. At baseline and 3 weeks after starting WT, cardiac function, 6-minute walk distance (6MWD), flow mediated dilation (FMD) of the brachial artery, and SF36-QOL scores were determined.
WT significantly improved left ventricular ejection fraction (LVEF), B-type natriuretic peptide (BNP), 6MWD, and FMD (3.6 ± 2.3 to 5.1 ± 2.8%, P < 0.01). Moreover, WT significantly improved not only the physical (PC) but also mental component (MC) of the QOL scores. WT-induced improvement of PC was negatively correlated with changes in BNP (r = -0.327, P < 0.05), but MC improvement was not related directly to changes in BNP, LVEF, or 6MWD. WT-induced changes in MC were not parallel to PC improvement.
WT improved QOL as well as cardiac function and exercise capacity in patients with CHF. Mental QOL improved independently of WT-induced improvement of cardiac function and exercise capacity.
... Compared with other chronic diseases and other cardiac conditions, patients with HF are more likely to report impaired QOL, 9,10 and this impairment has shown to directly correlate with worsening New York Heart Association (NYHA) functional class. 11 One of the factors contributing to the poor QOL is depression that has been reported to affect 1 out of every 4 individuals with HF. 12 Among patients with HF, concurrent depression has been shown to affect the perception of disease severity, with an increase in subjective symptoms of HF as measured by Kansas City Cardiomyopathy Questionnaire (KCCQ) and NYHA. ...
-Previous studies have demonstrated the psychosocial impact of Heart Failure in patients with reduced ejection fraction (EF). However, the effects on patients with preserved EF have not yet been elucidated. The present study aimed to determine the baseline characteristics of participants with Heart Failure with preserved ejection fraction (HFpEF) as it relates to impaired quality of life (QOL) and depression, identify predictors of poor QOL and depression, and determine the correlation between QOL and depression.
-Among patients enrolled in the TOPCAT trial, 3400 patients completed the Kansas City Cardiomyopathy Questionnaire (KCCQ), 3395 patients completed EuroQOL 5D Visual Analog Scale (EQ-5D VAS), and 1431 patients in US and Canada completed the Patient Health Questionnaire-9. The mean summary score on the KCCQ was 54.8; and on EQ-5D VAS was 60.3; 27% of patients had moderate to severe depression. Factors associated with better KCCQ and EQ-5D VAS via multiple logistic regression analysis (MLRA) were American region, older age; no history of angina pectoris or asthma, no use of hypoglycemic agent; more activity level; and lower NYHA class. Factors associated with depression via MLRA included younger age, female gender, comorbid angina, COPD, use of a hypoglycemic agent, lower activity level, higher NYHA class, and SSRI use. There were significant correlations between each of the QOL scores and depression.
-Patients with HFpEF who were younger, had higher NYHA class or comorbid angina pectoris, had lower activity levels, lived in Eastern Europe or were taking hypoglycemic agents, were more likely to have impaired QOL and depression. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT00094302.
... Normative data are available for healthy subjects stratified by age and sex and for a range of patient groups, including diabetes mellitus, 30 renal disease, 31 and congestive heart failure. 32 The influence of severe obesity and the remedial effect of substantial and sustained weight loss 33 on SF-36 scores have also been documented. The SF-36 category and summary scores that we observed in our subjects with uncontrolled hypertension were markedly reduced, particularly in those categories related to mental health. ...
The Postural Orthostatic Tachycardia Syndrome (POTS) is a condition in which heart rate increases abnormally when the individual assumes an upright position. In addition to the marked tachycardia, presyncope, and syncope, patients with POTS often complain of light-headedness, fatigue, and difficulty in concentrating. The present study assessed individuals with POTS for psychiatric comorbidity, anxiety sensitivity and health related quality of life and examined general cognitive ability. Data was obtained from patients with POTS (n = 15, 12 female, aged 30 ± 3 years) and age matched healthy subjects (n = 30, 21 female, aged 32 ± 2 years). Patients with POTS commonly presented with symptoms of depression, elevated anxiety and increased anxiety sensitivity, particularly with regards to cardiac symptoms, and had a poorer health related quality of life in both the physical and mental health domains. While patients with POTS performed worse in tests of current intellectual functioning (verbal and non-verbal IQ) and in measures of focused attention (digits forward) and short term memory (digits back), test results were influenced largely by years of education and the underlying level of depression and anxiety. Acute changes in cognitive performance in response to head up tilt were evident in the POTS patients. From results obtained, it was concluded that participants with POTS have an increased prevalence of depression and higher levels of anxiety. These underlying symptoms impact on cognition in patients with POTS, particularly in the cognitive domains of attention and short-term memory. Our results indicate that psychological interventions may aid in recovery and facilitate uptake and adherence of other treatment modalities in patients with POTS.
