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Effect of selenium on ROS, reactive oxygen species, in the nasopharyngeal cancer cells. The respective images from three independent experiments.
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The present study evaluated the protective effect of selenium against cisplatin-induced nasopharyngeal cancer in the cardiac tissue of adult rats. Male Wistar rats were divided into 4 groups of 6 rats each. Different combinations of selenium and cisplatin were administered for 45 days, following which the animals were sacrificed and the nasopharyng...
Citations
... Selenium increase the anticancer activity in MCF7 cells of breast cancer through the transient receptor potential vanilloid 1 (TRPV1) cation channel with or without cisplatin activity [77]. Selenium also shows anticancer effects in cisplatin-induced nasopharyngeal cancer through the activity of caspase 3 [78]. Cobalt became anticancer agent and nontoxic with combination of other anticancer agent through induction of autophagy, cell cycle arrest, and inhibition of cell invasion and P-glycoprotein (P-gp)activity [79]. ...
Recently, nanomedicine has had a great impact on drug discovery and made the way for the drug delivery system for therapeutic utility. There are many nanoscale products increasing in the research field and in the medical sector. Nanoparticle modified drugs are being developed and brought into the market for the treatment of cancer. The nanoparticle drug carrier can improve the stability of the drug by decreasing the cancerous cell and involving the drug at disease site. Essential trace elements are mostly important for the physiological and biochemical aspects in the human system. Nowadays nanotrace elements are used for the treatment of prostate cancer. In this review the venture and exploration of application of nanomedicine and the use of nanoparticles with essential trace elements will give a wide range of benefits for the treatment for prostate cancer.
... Selenium increase the anticancer activity in MCF7 cells of breast cancer through the transient receptor potential vanilloid 1 (TRPV1) cation channel with or without cisplatin activity [77]. Selenium also shows anticancer effects in cisplatin-induced nasopharyngeal cancer through the activity of caspase 3 [78]. Cobalt became anticancer agent and nontoxic with combination of other anticancer agent through induction of autophagy, cell cycle arrest, and inhibition of cell invasion and P-glycoprotein (P-gp)activity [79]. ...
Recently, nanomedicine has had a great impact on drug discovery and made the way for the drug delivery system for therapeutic utility. There are many nanoscale products increasing in the research field and in the medical sector. Nanoparticle modified drugs are being developed and brought into the market for the treatment of cancer. The nanoparticle drug carrier can improve the stability of the drug by decreasing the cancerous cell and involving the drug at disease site. Essential trace elements are mostly important for the physiological and biochemical aspects in the human system. Nowadays nanotrace elements are used for the treatment of prostate cancer. In this review the venture and exploration of application of nanomedicine and the use of nanoparticles with essential trace elements will give a wide range of benefits for the treatment for prostate cancer.
... form of increased serum urea and creatinine levels. In 2016, Zhu and his colleagues [31] reported similar results from the use of selenium to reduce liver toxicity during cisplatin-based treatment of nasopharyngeal cancer. The protective effect of selenium arose from the activity of caspase 3, which significantly increased after selenium administration. ...
Platinum compounds are used to treat various types
of cancer due to their tumor-suppressive
effects. One of the active platinum compounds is
cisplatin. Cisplatin is a well-known chemotherapy
drug that has been used to treat many human cancers
including bladder, head and neck, lung, ovarian, and
testicular cancers. It is also effective against
different types of cancers, including germ cell
tumors, lymphomas and sarcomas. However, this
drug has shown harmful complications in clinical
studies. This study aimed to investigate the side
effects of two doses of cisplatin, and to compare the
abilities of D-penicillamine and selenium, alone or
in combination, to reduce or prevent adverse side
effects of two doses of cisplatin in experimental
animals. The results indicated that treatment with
cisplatin caused defects in liver, pancreas, muscle
and bone marrow function. Results of this study also
showed that the combined injection of D-
penicillamine and selenium, along with a
therapeutic dose of cisplatin was effective in
protecting against the adverse side effects of
cisplatin alone. The results of this study are very
promising in reducing the side effects of this
effective drug, so this study recommends doing
more future studies to confirm the effectiveness of
using both D-penicillamine and selenium with
cisplatin to make sure that their effectiveness against
cancer was not affected, and this gives great hope
in use of cancer chemotherapy without any harmful
side effects.
___________
[The research that won the first place in the field of medicine
and health in the 39th session of the Rashid Bin Humaid
Award for Culture and Science]
... These data indicates that cisplatin can induce a state of oxidative stress. The same findings were documented by Zhu et al. [41] . ...
... Biologically, among the fundamental trace element is Selenium (that is found in food as meat products, cereals, fruits, vegetables, and milk). It obtains a remarkable interest as it is vital human's micronutrient as it contributes as in immune responses and endocrine functions beside different cellular and physiological mechanisms [12,13] with antioxidant characters [14]. Several degenerative disorders are related with Selenium deficiency and it has been extensively used in the treatment of various pathophysiological states as in cervical, hepatic and renal malignancies [15]. ...
T HE goal of this study is to see if selenium can counteract the effects of cyclophosphamide on albino rats' submandibular salivary gland tissues. 24 male rats were separated into four groups, each with 6 rats aged 12-16 weeks weighing 300-400 grams: the first was given physiological saline orally, the second was given selenium (200 mg/kg) orally for 14 days, and the third group was given cyclophosphamide orally once (150 mg /kg). On day 8, group 5 th group(IV) got selenium (200 Mg/kg) and cyclophosphamide (150 mg/kg) intraperitoneally (i.p.). On day 15, all rats were sedated and slaughtered, and the salivary glands of the submandibular region were collected. In comparison to the other groups, the third group lost weight significantly. The histopathological study revealed mucosal acini necrosis with edema surrounding the striated ducts, as well as mucosal acini cell atrophy and vacuoles in the serous acini. A decrease in the number of granulocytic convoluted tubules, an increase in fibrous tissue surrounding the interlobular ducts, and serous acinar apoptosis characteristics were also seen. In comparison to the other groups with moderate to severe foci, immunohistochemical results in this group demonstrated modest to the negative expression of (anti-apoptotic Bcl-2 protein) in stromal cells among the acinar cells of the salivary glands. We concluded that cyclophosphamide caused structural alterations in the submandibular salivary glands of rats and that selenium alleviated these side effects, as seen by histological investigation and immunohistochemistry analysis of Bcl-2 expression.
... In addition, Se deficiency can also affect the growth and development of humans and animals, resulting in a declined immunity and antioxidant capacity, and may cause a variety of diseases, such as coronary heart disease and tumours (Abedi et al., 2018;Jiang et al., 2018). Therefore, to analyse the physiological functions of Se and its molecular mechanisms regulating the growth and development of organisms and how to effectively utilise its dual biological functions has become important research topics for researchers in recent years (Abedi et al., 2018;Jiang et al., 2020a,b;Wang et al., 2016;Zhu et al., 2016). ...
Selenium (Se) is a vital micronutrient for the growth and development of organisms; however, its deficiency and toxicity pose worldwide challenges. Herein, we investigated the absorption, accumulation effect, and distribution of Se in silkworms, and tested the effect of Se feeding on the antioxidant indexes of silkworm haemolymph. Results showed that low concentrations of Se (50 μM and 100 μM) significantly increased the enzyme activities of catalase, glutathione peroxidase, glutathione S-transferase and superoxide dismutase in the silkworm haemolymph compared to control and 200 μM group. In addition, metabonomic analysis could reveal the metabolic changes in silkworm haemolymph after treatment with different concentrations (50 μM, and 200 μM) of Se. Compared to un-treatment group, the amount of 90 metabolites in both of 50 μM and the 200 μM Se-treated groups displayed significant differences, with 50 up-regulated and 40 down-regulated in 50 μM group, 36 up-regulated and 54 down-regulated in 200 μM group, respectively. The main different metabolites were amino acids, carbohydrates, lipids, nucleotide metabolites and their derivatives. These results suggest that Se could affect the carbohydrate metabolism in silkworms. The difference in metabolites was subject to different changes under different concentrations of Se and consequently altered their metabolic functions to meet the required energy demands under the Se toxic stress conditions.
... Besides, the deteriorative alterations are induced mostly by oxidative stress exerted by cisplatin, suggesting that cisplatin promotes oxidative stress through the depletion of antioxidant activities (Yilmaz et al., 2004. Zhu et al. (2016) reported that oxidative stress exerted by cisplatin also enhances the permeability of the mitochondrial membrane liberating pro-apoptotic proteins (Bax, Bak), which in turn stimulate several caspases concerned with apoptosis. ...
Background
Despite evidence of neurotoxicity, cisplatin is still considered the most potent drug prescribed in human chemotherapy for a broad spectrum of malignancies. The objective was to evaluate the cerebellar cortex damage including oxidative stress biomarkers and histopathology aspects in male mice. One saline control group and two cisplatin groups were intraperitoneally injected with 0, 5, and 10 mg/kg body weight (bw) cisplatin, twice per week for four successive weeks, respectively.
Results
Cisplatin decreased the body weights of treated mice. Serum levels of superoxide dismutase and glutathione peroxidase were significantly reduced in the 5 and 10 mg/kg dose, twice weekly for 4 weeks treatment; in contrast, there was a significant increase of lipid peroxidation. 5 and 10 mg/kg bw of cisplatin caused histopathological damage in the cerebellum tissue characterized by disruption, disorganization, and degeneration with dense pyknotic nuclei of the granular cells. Ultrastructurally, in the cortical region of the cerebellum, the Purkinje cells showed irregular pyknotic nuclei with indistinct nucleoli, cytoplasmic vacuolation, marked indentation of the nuclear membrane, dilatation of the endoplasmic reticulum, and breakdown and disappearance of mitochondrial cristae. Moreover, the molecular layer showed cellular necrosis and an increased number of lysosomal particles. The myelinated nerve fibers showed degenerative areas distinct by splitting, disruption, and loss of the lamellar pattern of the myelin sheath.
Conclusion
These findings provide a confirmed foresight that the in vivo potential treatment of mice with cisplatin induces cerebellum deficits and impairment in neuronal histology. The identified mechanism which evokes neurotoxicity is oxidative stress-dependent status. This mechanism is pharmacologically boosted by great production of free radical reactive oxygen species.
... Compared with controls, we found significant (P < 0.05) declines in serum caspase (~-10 to -17%) in those given selenium nanoparticles with or without galactose ( Figure 6) whereas in rats given only galactose, we found large increases (~18%). Zhu et al., (2016) found that mRNA expression of p53, bax and caspase 3 declined in rats given cisplatin but increased following selenium treatment. Maiyo and Singh (2017) maintained that selenium could inhibit cancer by protecting DNA damage by free radicals and/or apoptosis. ...
Jary Al-Kurdy MJ, Khudair KK., Effect of selenium loaded Ribes nigrum nanoparticles on genetic markers of male rats with D-galactose induced toxicity, Onl J Vet Res., 24 (5):312-327, 2020. Authors report effect of selenium nanoparticles loaded with black currant (Ribes nigrum) extract on serum caspase3, chromosomes, mitotic index, liver tunel cells and apoptosis in Wistar male rats given 150mg/kg D-galactose IP daily for 56 days. We generated 18-50nm spherical crystallite nanoparticles identified by UV spectroscopy, electron microscopy and X-ray diffraction. Groups of 8 rats each were then injected 150mg/kg D-galactose IP dissolved in 0.9% saline daily for 8 weeks (Group 1), gavaged 1mg/kg nanoparticles (2) or given both (3). Controls were given saline IP and orally (4). At days 14 and 56, cardiac blood was taken for caspase-3 and femur bone excised for chromosomal aberration and mitotic indices, and livers for DNA fragmentation and apoptosis. Compared with controls, we found significant (P < 0.05) declines in serum caspase (~-10 to-17%), and chromosomal acentric aberrations (~-4 fold) in rats given nanoparticles with or without galactose. In rats given only galactose we found large increases in serum caspase-A (~18%) chromosomal abberations (~12 fold) and mitotic indices (~34%). We found no tunnel liver cells in rats given selenium loaded Ribes nigrum nanoparticles with or without D galactose but present throughtout in those given only D-galactose. Results suggest that selenium loaded Ribes nigrum nanoparticles nanoparticles may reduce D-galactose genotoxicity in rats and exert anti-oxidants effects.
... Compared with controls, we found significant (P < 0.05) declines in serum caspase (~-10 to -17%) in those given selenium nanoparticles with or without galactose ( Figure 6) whereas in rats given only galactose, we found large increases (~18%). Zhu et al., (2016) found that mRNA expression of p53, bax and caspase 3 declined in rats given cisplatin but increased following selenium treatment. Maiyo and Singh (2017) maintained that selenium could inhibit cancer by protecting DNA damage by free radicals and/or apoptosis. ...
Jary Al-Kurdy MJ, Khudair KK., Effect of selenium loaded Ribes nigrum nanoparticles on genetic markers of male rats with D-galactose induced toxicity, Onl J Vet Res., 24 (5):312-327, 2020. Authors report effect of selenium nanoparticles loaded with black currant (Ribes nigrum) extract on serum caspase3, chromosomes, mitotic index, liver tunel cells and apoptosis in Wistar male rats given 150mg/kg D-galactose IP daily for 56 days. We generated 18-50nm spherical crystallite nanoparticles identified by UV spectroscopy, electron microscopy and X-ray diffraction. Groups of 8 rats each were then injected 150mg/kg D-galactose IP dissolved in 0.9% saline daily for 8 weeks (Group 1), gavaged 1mg/kg nanoparticles (2) or given both (3). Controls were given saline IP and orally (4). At days 14 and 56, cardiac blood was taken for caspase-3 and femur bone excised for chromosomal aberration and mitotic indices, and livers for DNA fragmentation and apoptosis. Compared with controls, we found significant (P < 0.05) declines in serum caspase (~-10 to-17%), and chromosomal acentric aberrations (~-4 fold) in rats given nanoparticles with or without galactose. In rats given only galactose we found large increases in serum caspase-A (~18%) chromosomal abberations (~12 fold) and mitotic indices (~34%). We found no tunnel liver cells in rats given selenium loaded Ribes nigrum nanoparticles with or without D galactose but present throughtout in those given only D-galactose. Results suggest that selenium loaded Ribes nigrum nanoparticles nanoparticles may reduce D-galactose genotoxicity in rats and exert anti-oxidants effects.
... Previous studies reveal that biological functions of Se are highlighted as vital nutrient and its adequate supplementation can prevent cancers in animals and humans [12,17,18]. Moreover, amino acids from Se-rich silkworm pupas were reported to induce apoptosis in the hepatoma cells [19]. ...
The effects of selenium (Se) on the growth and reproduction of the Lepidoptera insect, the silkworm, Bombyx mori L were investigated. Initially, the silkworms were divided into eight groups (150 larvae/group) on the basis of feeding with mulberry leaves saturated with different concentrations of Se (25, 50, 100, 125, 150, 175, and 200 μM) and control from the first day of the fourth instar larvae. After feeding, growth and reproductive performance of B. mori L. were investigated with standard techniques used in sericulture. After the data analysis, 50 μM of Se was recognized as the optimal level which positively influenced the growth and production, with prolonged stage of larvae, increased larval, cocoon, and pupal weights, and enhanced number of eggs laid by the female moth as compared to the control group. On the contrary, 200 μM of Se treatment displayed toxic to silkworm and induced significant decrease in the growth, cocoon production, and reproduction. The weight of the cocoon shell, the cocoon shell ratio, number of eggs produced, and fertilization ratio in all the Se-treated groups were lower than the control group. The present study indicated that lower levels of (50 μM) of Se can promote the larval and pupal growth of the B. mori L. resulting in the higher yield of cocoon crop and significantly influencing the fecundity, while high concentration was toxic to silkworm. Our data supply the novel application of Se which could be highly beneficial to sericulture farmers.
