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Effect of restraint stress on the levels of AGEs with and without SMF (0.8 mT) during 30, 60, and 240 min. The results were analyzed by analysis of variance (ANOVA), and Dunnett’s multiple comparison test was used to compare the outcomes between the experimental and control groups. Data are represented by the mean ± standard error of the mean (n=8 per group). p∗∗<0.01 and p∗∗∗<0.001 versus control group; p##<0.01 versus 60 and 240 min without SMF and p°<0.05 versus control group.
Source publication
Stress is a state of vulnerable homeostasis that alters the physiological and behavioral responses. Stress induces oxidative damage in several organs including the brain, liver, kidney, stomach, and heart. Preliminary findings suggested that the magnetic stimulation could accelerate the healing processes and has been an effective complementary ther...
Citations
... Due to the influence of hyperglycemia environment, the metabolism of glucose and lipid in DM patients was disordered, which would release a large number of oxygen free radicals, inhibit the ability of free radical scavenging in a feedback way, resulting in imbalance of antioxidant function, enhanced OS, increased levels of ROS, oxidative damage of islet β cells, resulting in impaired function, enhanced IR and induced T2DM [39]. Sod, as an antioxidant, was the first line of defense against OS, which could specifically scavenge superoxide anion free radicals [40]. Liu J et al [41] observed that compared with healthy mice, the levels of ROS in β-cells of T2DM mice increased and the levels of SOD decreased, which indicated that OS was induced in T2DM. ...
Background
Insulin resistance (IR) was a prominent feature commonly observed in individuals with type 2 diabetes mellitus (T2DM). T2DM Individuals often exhibited a concomitant presence of low-grade chronic inflammation. In this study conducted retrospectively, the aim was to investigate the connection between neutrophils-lymphocytes rate (NLR), monocytes-lymphocytes rate (MLR), platelets-lymphocytes rate (PLR) and IR, specifically among individuals with T2DM.
Method
This study encompassed a cohort of 405 individuals diagnosed with T2DM, comprising cases from January 2021 to November 2022. On the basis of whether there was IR or not, these sufferers were categorized into two cohorts, namely T2DM with IR group (292 cases) and T2DM without IR group (113 cases), as determined by a homeostasis model assessment-IR (HOMA-IR) value exceeding 2.0.
Results
The findings of this study demonstrated compelling evidence of distinct biomarker profiles between individuals with T2DM who had IR and those without IR. Specifically, the IR individuals displayed notably raise NLR, MLR, PLR, C reactive protein (CRP) and serum amyloid A (SAA). Additionally, there was a noticeable decrease in superoxide dismutase (SOD) levels. Furthermore, IR was negatively correlated with SOD values, while positive associations were found between IR and NLR, CRP, and SAA levels (p < 0.05). Moreover, a rise in NLR and PLR levels demonstrated an identical relationship with the prevalence of IR (p = 0.007, p = 0.025, separately). The Receiver operating characteristic (ROC) curve demonstrated that the areas under the curve (AUC) for NLR, MLR, PLR, CRP, SAA and SOD in predicting occurrence of IR in T2DM patients were 0.603, 0.575, 0.581, 0.644, 0.594 and 0.632 respectively, with sensitivity of 79.5%, 95.2%, 46.9%,54.1% (or 51.4), 47.6% (or 45.7%) and 98.6% and specificity of 37.2%, 19.5%, 69.9%, 69% (or 71.7%), 71.6% (or 73.5%) and 23% respectively.
Conclusion
Our findings support the notion that higher magnitude of NLR, PLR, MLR, CRP, and SAA values, corresponded to lower SOD levels, indicating a more severe degree of IR in T2DM patients. Additionally, NLR, PLR, MLR, CRP, SAA, and SOD demonstrated predictive potential for assessing IR. Regrettably, due to the retrospective nature of this study, it was not feasible to take a measurement the majority of inflammatory factors and reactive oxygen species (ROS).
... Oxidative stress and inflammation are the two main mechanisms responsible for vascular remodeling (44). Numerous studies on the oxidative stress induced by MCT injection show a decrease in glutathione (GSH) and an increase in malondialdehyde (MDA) (45). In this study, the measurement of SOD, CAT, and GSH enzymes in the heart tissue of MCT rats showed a decrease. ...
Objective(s)
Right ventricular hypertrophy (RVH) often results in failure of the right ventricle or even the left ventricle. Rosmarinic acid (RA), a natural polyphenol, is commonly found in Boraginaceae species and some species of ferns and hornworts. This study looked at how RA affects oxidative stress and left ventricular hemodynamic functions as well as RVH in monocrotaline (MCT) induced RVH model rats.
Materials and Methods
To cause RVH, MCT (60 mg/kg) was intraperitoneally (IP) injected. Rats were given saline or RA (10, 15, and 30 mg/kg, gavage, over 21 days). In anesthetized rats, the lead II electrocardiogram was recorded. The hemodynamic functions of the isolated heart were measured using the Langendorff apparatus (at constant pressure). Investigations were made into the right ventricular hypertrophy index (RVHI), the activities of superoxide dismutase, catalase, glutathione, and Wnt and β-catenin gene expressions in the left ventricle. H&E staining was used.
Results
A significant decline in electrocardiogram parameters and anti-oxidant enzyme activities, an increase in QTc (Q-T corrected) intervals, MDA (Malondialdehyde), RVHI, and Wnt/β-catenin gene expression, and also significant changes in the hemodynamic parameters were demonstrated in the MCT group. RA improved the above-mentioned factors.
Conclusion
According to the findings, RA may act as a cardioprotective agent against cardiovascular complications brought on by RVH due to its capacity to boost the activity of cardiac anti-oxidant enzymes and decrease the expression of genes involved in vascular calcification.
... Cells utilize the antioxidant defense system to eliminate ROS, thereby lightening the accumulative burden of OS. The first line of defense against OS, consisting of GSH and SOD, can suppress the formation of free radicals and restrain oxidative damage [51]. MDA is the outcome of lipid peroxidation, which is widely used as an indicator of OS [14]. ...
Objective Type 2 diabetes mellitus (T2DM) is a common metabolic disorder with rising incidence worldwide. This study explored the anti-T2DM role of vitamin D, thereby providing novel therapeutic strategies.
Methods C57BL/6 J mice and MIN6 cells were used to induce in vivo T2DM and damaged β-cell models, respectively. Body weights, fasting blood glucose, and fasting insulin were measured in mice. Oral glucose tolerance test (OGTT) and insulin tolerance test (ITT) were conducted on mice. Lipid indices (TG, TC, LDL-C, and HDL-C) were detected in mouse serum. Hematoxylin-eosin staining was used to evaluate pancreatic tissue injury. ELISA was used to assess insulin and oxidative stress (OS) markers (MDA, GSH, and SOD) in mice and MIN6 cells. Production of ROS was detected in islet β-cells and MIN6 cells. Cell viability and apoptosis were evaluated using CCK-8 and flow cytometry, respectively. QRT-PCR and western blotting were used to detect pro-inflammatory factors (TNF-α and IL-6) and endoplasmic reticulum stress (ERS) markers (CHOP and GRP78), respectively.
Results Vitamin D reduced body weights, fasting blood glucose, and insulin and ameliorated glucose tolerance and insulin sensitivity in T2DM mice. Besides, vitamin D decreased serum TG, TC, LDL-C, and increased HDL-C in T2DM mice. Vitamin D inhibited pancreatic histopathological injury, cell apoptosis, OS, and β-cell decline in T2DM mice. Moreover, vitamin D alleviated cell death, insufficient insulin secretion, inflammation, OS, and ERS in damaged MIN6 cells. Notably, N-acetyl-L-cysteine (an OS inhibitor) enhanced these effects of vitamin D.
Conclusions Vitamin D relieved T2DM symptoms by alleviating OS-induced β-cell impairment.
... These mechanisms are mostly related to magnetic interactions with enzyme catalyzed-biochemical processes. In addition, it has been reported that magnetic fields are related to oxidative stress Coballase-Urrutia et al., 2018) and antioxidant systems (Scaiano et al., 1994;Li and Chow, 2001;Kula et al., 2002;Zhang et al., 2003) in living organisms. ...
... These mechanisms are mostly related to magnetic interactions with enzyme catalyzed-biochemical processes. In addition, it has been reported that magnetic fields are related to oxidative stress Coballase-Urrutia et al., 2018) and antioxidant systems (Scaiano et al., 1994;Li and Chow, 2001;Kula et al., 2002;Zhang et al., 2003) in living organisms. ...
Increasing interest on biological effects of electromagnetic radiation, particularly extremely-low-frequency electromagnetic fields (ELFEMFs) has been observed. Although harmful effects of magnetic fields in humans remain to be demonstrated, it has been proposed that oxidative stress may represent one of the causes of ELF- EMFs adverse effects. We investigated the influence of ELF-EMFs on enzyme activity in tobacco plants under oxidative stress. Nicotiana tabacum (L.) seedlings of the Xanthi variety were continuously exposed to 2.0 mT and 60 Hz frequency ELF-EMFs for 24, 48, 72, and 96 h. The biochemical endpoints measured involved leaf and root extracts ascorbate peroxidase (APX) and catalase (CAT) activities, which were increased in leaf extracts after 48, 72, and 96 h of magnetic field exposure, whereas APX and CAT activities in root extracts increased after 48 and 72 h and 48, 72, and 96 h of continuous exposure to magnetic fields. In contrast, ELF-EMF exposure for 24 h did not alter APX and CAT activities in leaf and root extracts. All treatment regimens were matched with a properly sham-exposed control. These results suggest that ELF-EMFs induce an oxidative stress, which may potentiate the oxidative defense system in tobacco plants
... 16 The combination of PBMT with SMF (PBMT-SMF) could o er a complementary therapy by attenuating oxidative stress. 17 This study aimed to evaluate the performance of a PBMT-SMF device on pain, redness, and edema in patients treated with lasers, RFI, or RFF for di erent dermatological conditions. BACKGROUND: Photobiomodulation therapy (PBMT) can signi cantly reduce in ammation and relieve pain, including postoperative pain and edema. ...
Background:
Photobiomodulation therapy (PBMT) can significantly reduce inflammation and relieve pain, including postoperative pain and edema. The study aimed to evaluate the performance of a photobiomodulation-based device that includes a static magnetic field (SMF) to treat laser- or intensive and fractional radiofrequency-related side effects, such as pain, redness, and edema in patients treated for different dermatological conditions.
Methods:
The study had a prospective, non-randomized, single-center design. Male and female patients aged 18 years or older underwent one or two PBMT-SMF (anti-inflammatory or anti-edematous) sessions on the same day, once or twice a week, after laser or radiofrequency facial treatments due to various dermatological disorders. Variables and efficacy assessments were pain, redness, edema, and their reduction from baseline to the last visit.
Results:
Twenty-seven patients were included, seven (25.9%) men and 20 (74.1%) women, with a mean (SD) age of 43.7 (14.1) years. Seven (25.9%) patients were treated with radiofrequency, and 20 (74.1%) patients with a vascular laser (three [15%] for angioma, two [10%] for scars, three [15%] for erythrosis, and 12 [60%] for rosacea). After the PBMT-SMF protocol, overall mean pain reduction was 40 percent, and redness and edema reduction were shown by the pictures taken before and after the PBMT-SMF procedure.
Limitations:
The primary limitations were the small number of patients and no quantitative variables for redness and edema.
Conclusion:
PBMT-SMF reduced edema and inflammation after treatment with lasers or intensive or fractional radiofrequency for facial conditions, and probably, analgesic and anti-inflammatory drugs.
... It is important to consider that MF application to biological systems may cause oxidative stress by the action of free radicals or the interaction with the membrane's structure [12,59,60]. Microalga cultivated under MF influence may use additional energy to counteract the negative effect of increased oxidative stress, which consequently, may reduce the level of biomolecules, such as carbohydrates and pigments. ...
Microalgae and cyanobacteria include procaryotic and eucaryotic photosynthetic micro-organisms that produce biomass rich in biomolecules with a high value. Some examples of these biomolecules are proteins, lipids, carbohydrates, pigments, antioxidants, and vitamins. Currently, microalgae are also considered a good source of biofuel feedstock. The microalga-based biorefinery approach should be used to promote the sustainability of biomass generation since microalga biomass production can be performed and integrated into a circular bioeconomy structure. To include an environmentally sustainable approach with microalga cultures, it is necessary to develop alternative ways to produce biomass at a low cost, reducing pollution and improving biomass development. Different strategies are being used to achieve more productivity in cultivation, such as magnets in cultures. Magnetic forces can alter microalga metabolism, and this field of study is promising and innovative, yet remains an unexplored area. This review presents the current trends in the magnetic biostimulation of microalgae for the application of cultivated biomass in different areas of biotechnology, biofuel, and bioenergy production, as well as environmental protection.
... Moreover, it is known that the cellular production of ROS is susceptible to magnetic field exposure [136,227,[620][621][622][623][624][625][626][627][628][629][630][631][632][633][634][635][636][637]. ROS play vital roles in biology. ...
Hundreds of studies have found that weak magnetic fields can significantly influence various biological systems. However, the underlying mechanisms behind these phenomena remain elusive. Remarkably, the magnetic energies implicated in these effects are much smaller than thermal energies. Here, we review these observations, and we suggest an explanation based on the radical pair mechanism, which involves the quantum dynamics of the electron and nuclear spins of transient radical molecules. While the radical pair mechanism has been studied in detail in the context of avian magnetoreception, the studies reviewed here show that magnetosensitivity is widespread throughout biology. We review magnetic field effects on various physiological functions, discussing static, hypomagnetic and oscillating magnetic fields, as well as isotope effects. We then review the radical pair mechanism as a potential unifying model for the described magnetic field effects, and we discuss plausible candidate molecules for the radical pairs. We review recent studies proposing that the radical pair mechanism provides explanations for isotope effects in xenon anaesthesia and lithium treatment of hyperactivity, magnetic field effects on the circadian clock, and hypomagnetic field effects on neurogenesis and microtubule assembly. We conclude by discussing future lines of investigation in this exciting new area of quantum biology.
... Treatment was given for 20 minutes/day for 15 days over three weeks with no significant effects on either CRP or defensin in the diabetic patients. Others have suggested that SMF may have a role in mitigating oxidative stress [72]. ...
The use of electromagnetic field therapy (EMFT) is a non-invasive, potential alternative or complementary choice in the treatment of wounds, chronic pain, neuropathy, and other medical conditions, including tissue repair and cell proliferation. Static magnetic fields (SMFs) have been reported to increase microcirculatory blood flow by mediating vasodilation via nitric oxide. Studies report that SMF exposure causes homeostatic, normalizing effects on the vascular tone that may have beneficial effects in situations where tissue perfusion is limited, such as may be present in diabetes. Pulsed electromagnetic fields (PEMFs) have also shown promise in treating diabetic wounds by improving wound healing rates and other attributes. Our purpose was to critically review prior applications of EMFT for relevancy and effectiveness in treating diabetic complications. The goal was to provide information to allow for informed decisions on the possible use of these modalities in the treatment of persons with diabetic complications. The focus was on the following major areas: wound healing, neuropathy, blood glucose control, blood flow, inflammation and oxidative stress.
... G.A. Zakharov [21] demonstrated that under the influence of WSMF, the agn ts3 mutant exhibits a decrease in LIMK1 and HSP70 levels. In the same study, he substantiated for the first time the idea that, as shown by a comparison of heat shock and WSMF effects, WSMF can be accompanied by oxidative stress, which is also confirmed by other authors [22]. ...
