Effect of left ventricular lead stimulation site on QRS morphology in V1.

Effect of left ventricular lead stimulation site on QRS morphology in V1.

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Background: With increasing use of cardiac resynchronization therapy (CRT), treating physicians should be familiar with different electrocardiographic (ECG) patterns of left ventricular (LV) lead and biventricular (BiV) pacing. However, there are a few publications on ECG patterns during BiV pacing. Purpose: This study was sought to determine di...

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... the device features effect of LV lead position, VV interval, and AV interval were investigated. While moving LV pacing site from the ALCV to the PLCV and getting more closer to RV pacing site, we found a higher rate of dominant R wave in V1 (Table 1). ...

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Citations

... R or r waves in V 1 were observed in 65% to 93% of patients with biventricular pacing. 526,527 CRT loss may occur during exercise in the presence of AF with high ventricular rate or due to AV interval shortening; 24hour Holter monitoring and exercise stress test may be useful to identify such cases. Increased LV capture thresholds account for 10% of cases of CRT pacing loss. ...
... Ondas r ou R em V1 estão presentes em 65% a 93% das estimulações biventriculares. 526,527 A perda da ressincronização pode ocorrer ao esforço, na presença de FA de alta resposta e devido ao encurtamento do intervalo AV; Holter-24h e teste ergométrico podem ser úteis para identificar tais cenários. Aumento do limiar de captura do VE é responsável por 10% dos casos de perda da ressincronização. ...
... interkostal aralıklardan) alınması gibi durumlarda da V1'de negatif bir QRS konfigürasyonu izlenebilmektedir. [10,14,15] Herweg ve ark., [10] V1'de negatif QRS kompleksinin varlığının SV uyarı bölgesinde uzamış latansı (≥40 ms) öngörmedeki duyarlılığını %80, özgüllüğünü ise %97 olarak belirlemişlerdir. Bunun dışında, SğV elektrodunun SğV çıkış yoluna veya interventriküler septuma yerleştirildiği biventriküler uyarı zamanı da genellikle V1'de negatif QRS kompleks olarak izlenmektedir (Şekil 3). ...
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Article
Introduction: Dyssynchrony persists in many patients despite cardiac resynchronization therapy (CRT). Aim of this proof-of-concept study was to achieve better CRT, with a QRS approximating the normal width and axis, by using His bundle pacing and non-conventional pacing configurations. Methods and results: In 20 patients with CRT indications, we performed an acute intra-patient comparison between conventional biventricular (CONV) and three non-conventional pacing modalities: His bundle pacing alone (HBP), His bundle and coronary sinus pacing (HBP+CS) and HBP+CS plus right ventricular pacing (TRIPLE). Electrical dyssynchrony was assessed by means of QRS width and axis; "quasi-normal" axis meant an R/S ratio ≥1 in leads I and V6 and ≤1 in V1. Mechanical dyssynchrony was assessed by speckle tracking echocardiography. QRS width was 153±18 ms on CONV, shortened to 137±16 ms on HBP+CS (p=0.001) and to 130±14 ms on TRIPLE (p=0.001), while it remained unchanged on HBP (159±32 ms, p=0.17). The rate of patients with "quasi-normal" axis was 5% on CONV, and increased to 90% on HBP (p=0.0001), to 63% on HBP+CS (p=0.001) and to 44% on TRIPLE (p=0.02). On radial strain analysis, the time-to-peak difference between antero-septal and postero-lateral segments was 143±116 ms on CONV, shortened to 121±127 ms on HBP (p=0.79), to 67±70 ms on HBP+CS (p=0.02) and to 76±55 ms on TRIPLE (p=0.05). On discharge, HBP was chosen in 15% of patients, HBP+CS in 55% and TRIPLE in 30%; CONV was never chosen. Conclusion: Non-conventional modalities of CRT provide acute additional electrical and mechanical resynchronization. An inter-patient variability exists. This article is protected by copyright. All rights reserved.