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Effect of inositol-stabilized arginine silicate complex (ASI) and magnesium biotinate (MgB) on the density of hair (1/cm²) (A), the anagen (B) and telogen (C) ratios (%), and in rats. Control: shaved; ASI: shaved + ASI (4.14 mg/rat/day); ASI + MgB I: shaved + ASI (4.14 mg/rat/day) + MgB (48.7 μg/rat/day); ASI + MgB II: shaved + ASI (4.14 mg/rat/day) + MgB (325 μg/rat/day)
Source publication
The purpose of this study was to examine the effects of a combination of inositol-stabilized arginine silicate complex (ASI) and magnesium biotinate (MgB) on hair and nail growth in an animal model. Twenty-eight female Sprague–Dawley rats (8 weeks old) were randomized into one of the following groups: (i) group (control), shaved; (ii) group (ASI),...
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Obesity and adult weight gain are linked to increased breast cancer risk and poorer clinical outcomes in postmenopausal women, particularly for hormone-dependent tumors. Menopause is a time when significant weight gain occurs in many women, and clinical and preclinical studies have identified menopause (or ovariectomy) as a period of vul...
Citations
... In the realm of hair function, inositol assumes a significant role, specifically in the intricate process of developing and maintaining hair cells. [41][42][43] It is worth noting that inositol phosphates, exemplified by inositol 1,4,5 trisphosphate, emerge as key players in the regulation of cytosolic calcium concentrations, a crucial aspect of hair cell function. ...
Background
MicroRNAs (miRNAs) are small RNA molecules that play a regulatory role in various biological processes by acting as intracellular mediators. They hold great potential as therapeutic agents for targeting human disease pathways; however, there is still much to be uncovered about their mechanism of gene regulation. Alopecia areata (AA) is a commonly occurring inflammatory condition characterized by the infiltration of T cells that specifically target the anagen‐stage hair follicle. The limited understanding of its precise cellular mechanism may be the reason behind the scarcity of effective treatments for AA.
Aim
The significance and function of hsa‐miR‐193a‐5p as a genetic marker for AA and its potential influence on the advancement of the disease.
Subjects and methods
A case‐control study comprised 77 individuals diagnosed with AA who were matched with 75 healthy controls. In order to measure the expression of miR‐200c‐3p in both groups, the real‐time PCR technique was utilized. The prediction of suitable genes for hsa‐miR‐193a‐5p, as well as the identification of pathways and gene‐gene interactions, were carried out using bioinformatic tools.
Results
The levels of hsa‐miR‐193a‐5p expression were notably elevated in AA patients in comparison to healthy controls. Our prediction suggests that the involvement of hsa‐miR‐193a‐5p in the development of AA is significant due to its influence on the inositol phosphorylation pathway and the Phosphatidylinositol signaling system, achieved through its direct impact on the IPPK gene.
Conclusion
For the first time, our study demonstrates the significant over‐expression of a new miRNA, hsa‐miR‐193a‐5p, in the blood of AA patients compared to controls, and highlights its impact on the IPPK gene and the inositol phosphorylation and Phosphatidylinositol signaling pathways, suggesting a potential therapeutic role for hsa‐miR‐193a‐5p in AA.
... Can arginine's role in promoting hair growth be exploited for AGA therapy? It has been found that the combination of inositol-stabilized arginine silicate complex and biomagnesium can promote the regeneration of mouse nails and hair, but in this study, the use of arginine alone did not promote hair regeneration 51 . In our preliminary exploration, the addition of arginine as a supplement demonstrated a positive impact on hair growth in balding HFs from AGA patients. ...
Androgenetic alopecia (AGA) is a prevalent hair loss disorder characterized by an unclear pathogenesis mechanism and limited therapeutic efficacy. Despite a growing body of evidence indicating a link between AGA and metabolic disorders, the precise role of metabolism in AGA development remains elusive. In this study, we employed targeted metabolome profiling to identify distinct metabolic signatures in AGA patients, with a particular focus on amino acid-related metabolic pathways. Notably, our findings highlight a significant decrease in serum abundance of arginine in AGA patients.Locally, impaired arginine metabolism in hair follicles (HFs) experiencing balding was assumed, as evidenced by the heightened expression of ARG1, the pivotal enzyme regulating the arginine-ornithine transition, and the diminished expression of the arginine transporter SLC7A1. Our study further demonstrated that arginine deficiency hinders human hair growth by antagonizing the mTOR signaling pathway. Moreover, the administration of arginine effectively safeguards against the inhibition of hair growth induced by DHT in an AGA-like mouse model and in balding HFs obtained from AGA patients.Collectively, these findings reveal that obstruction of anagen maintenance cause by arginine deficiency occurs in AGA patients and raise the possibility of supplementation with arginine as a promising clinical treatment strategy.
