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Effect of drug combination on the duration of continuous seizures. The longest duration of continuous seizures was observed in the PLC group while no continuous seizures were observed in the control and LEV+DFS group. In the LEV+DFS+PLC group, the duration of continuous seizures was 12mins which when compared to the PLC group there was a significant increase to 38mins. In the LEV+PLC group, the continuous seizures remained for 24mins.

Effect of drug combination on the duration of continuous seizures. The longest duration of continuous seizures was observed in the PLC group while no continuous seizures were observed in the control and LEV+DFS group. In the LEV+DFS+PLC group, the duration of continuous seizures was 12mins which when compared to the PLC group there was a significant increase to 38mins. In the LEV+PLC group, the continuous seizures remained for 24mins.

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Epilepsy, a neuronal disorder has affected 1% of the world's population. Almost 35-40% of these patients get resistant to available anti-epileptic drugs (AEDs). Recent studies have shown the role of inflammation in the pathophysiology of epilepsy and a combination of anti-inflammatory and antiepileptic drugs could prove beneficial against epileptic...

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... next parameter evaluated was the average duration of continuous seizures (fig. 4). The continuous seizures experienced by the disease model group were of increased severity leading to death and longest duration i.e. 38mins. When the disease group was compared with the combination treatment group (DFS+LEV+PLC) not only there was a significant decrease in the duration of continuous seizures but there was a difference ...