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Effect of congenital leptin deficiency on the number of Treg ells in vivo (A) Percentage numbers of peripheral CD4+CD25+ Treg cells in WT, leptin deficient ob/ob mice, and recombinant leptin-treated ob/ob mice. One representative out of three independent experiments with 8 mice per group is shown (*P < 0.02). (B) Percentage numbers of peripheral CD4+Foxp3+ Treg cells in WT and leptin deficient ob/ob mice. One representative out of three independent experiments with 7 mice per group is shown (**P < 0.02).

Effect of congenital leptin deficiency on the number of Treg ells in vivo (A) Percentage numbers of peripheral CD4+CD25+ Treg cells in WT, leptin deficient ob/ob mice, and recombinant leptin-treated ob/ob mice. One representative out of three independent experiments with 8 mice per group is shown (*P < 0.02). (B) Percentage numbers of peripheral CD4+Foxp3+ Treg cells in WT and leptin deficient ob/ob mice. One representative out of three independent experiments with 7 mice per group is shown (**P < 0.02).

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