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Objective:To evaluate hepatoprotective activity along with hematological and defensive recital of Trichosanthes dioica Roxb against simvastatin induced hepatotoxicity in experimental rodents. Methods: In the present study, in- vivo hepatoprotective effect of 50% methanolic fruit extract of Trichosanthes dioica Roxb (TME 200 and 400 mg/kg body weigh...
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... outcome in (Table 4) showed a significant change in RBC, Hb, PLT, WBC, and % Lymphocytes counts. RBC PLT, WBC, and % Lymphocytes counts significantly increased at the dose of 1000 and 2000 mg/kg, while Hb count non-significantly increases at the dose of 1000mg/kg as compared to control group. ...Similar publications
The present study aimed to assess the protective effects of tetramethylpyrazine (TMP) on the livers of mice fed a high fat diet. The mice were divided into five groups: Regular diet; high fat diet; simvastatin-treated; and low and high dose TMP-treated groups. The results demonstrated that, compared with the control group, serum glucose, total chol...
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... It possesses the Tikt, Katu Rasa (Taste) Laghu, Rooksha, Teekshan Guna with Katu Vipak and Ushan Veerya which relieve Agnimandya and does Rookshan, Chedan, and Lekhan of Meda Dhatu; which is the major treatment principle of the medohar chikitsa mentioned by Acharya Charak in Sutra Sthaan 21chapter. Several researches conducted in the past few years have indicated that Hepatoprotective potential has been proven of Patol [12,13,14] and Chitrak [15,16] possesses a range of pharmacological qualities like anthelminthic, antihyperlipidemic, antihyperglycemic antioxidant, antidiabetic, antipyretic, antimicrobial, hepatoprotective, anticancer, antifertility, antiulcer, antifungal, burns, and wound healing. Some pharmacological effects of Shatpushpa (Anethum graveolens) have been reported such as antimicrobial antihyperlipidemic and anti hypercholesterolemic activities. ...
Like other metabolic disorders, Medoroga (Dyslipidemia) is also troublesome. The burden is increasing day by day. It is caused by an abrupt change in lifestyle and dietary habits. In India, approximately 25–30% of urban and 15-20% of rural subjects suffer from dyslipidemia.
... Austria: DIALAB® Produktion und Vertrieb von chemisch-technischen). 19 The rat serum glucose level was measured by GOD-PAP. ...
Research on anti-diabetic herbal plants and their safety continues to grow by the increasing number of diabetics, especially in Indonesia, which is rich in plant biodiversity. This study investigated the effect of Sarang banua (Clerodendrum fragrans Vent Willd) leaf extract on the hepatoprotective effect, histology of the pancreas, and serum glucose levels of white male rats (Rattus novergicus) induced diabetes by alloxan. Diabetic rats were given ethanol extract of C. fragrans leaf (100, 200, and 300 mg/kg bw), ethyl acetate extract (200, 300 mg/kg bw), and metformin (125 mg/kg) orally for 14 days. Enzym activities and glucose levels in serum were determined at the end of treatments. The histology of rat pancreas and liver were observed under an electron microscope with 10x magnification. The data obtained were analyzed by ANOVA followed by the Least Significant Difference test. The results showed that the administration of ethanolic extract of C. fragrans leaves at 100mg/kg bw significantly decreased the serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT), and serum glucose levels in the alloxan-induced diabetic rat (p < 0.05). C. fragrans leaf extract decreased the level of histological damage liver and pancreas of alloxan-induced diabetic rats. The C. fragrans improved the protective effects on the liver, and pancreas, and decreased serum glucose in alloxan-induced diabetic rats.
... There were several cases that were reviews that describe the toxicity of simvastatin with other medications such as flutamide, and diltiazem. 49 Liver toxicity was prompted by the ingestion of simvastatin (20 mg/kg, p.o.) for 1 month. On the 31 th day, blood samples have been collected, and all the animals were sacrificed by using cervical disconnection and liver sample have been harvested, rinsed in saline for in addition biochemical analysis. ...
At this moment, liver dysfunction is a major source of destruction, and its widespreadity is accentuated in the developed republics. The liver is an imperative organ of the body and is involved in metabolism and regulation. The large number of medications, toxins, and plant-derived products has been claimed to cause liver dysfunction, which is potentially life intimidating to humans. Currently, there is a shortfall in encouraging treatment for treating patients with liver dysfunction due to the nonexistence of empathy for gesturing offenders serviceable in the pathogenesis of liver toxicity. Hepatic dysfunction is manifested by hepatic karyopyknotic, eosinophilic or acidophilic cell plasm, followed by excessive steatosis, liver injury, and oxidative degradation of lipids that cause centrilobular necrosis in hepatocytes. Different signaling mechanism, like activation of Kupffer cells, NK cells, inflammatory mediators, and ROS are associated with the pathogenesis of liver dysfunction. A good empathy of chief mechanisms is prerequisite for the scheming of novel curative medications. Consequently, animal models are being developed to impressionist hepatic ailments. From the several decades, researchers are using distinctive animal models for discovering and understanding pathogenesis of hepatic ailments and associated abusiveness. This current review has been framed to discuss numerous new and traditional experimental models for hepatotoxicity studies. Numerous animal models have been evolved to evaluate the pathogenesis and develop drugs for hepatotoxicity. Experimental modes of hepatotoxicity are influential for invention of novel molecular signaling trails for the improvement of human health.
... SGOT and SGPT were analyzed by spectrophotometric measurements (Dialab, 2006, Liquid Reagents of GOT, Austria: DIALAB Production von chemish-technishen.) [12]. ...
AIM: The hepatoprotective activities of bioactive compounds Pirdot were investigated in vivo and in silico. METHODS: In this study, the completely randomized design non-factorial was experimentally to assess the value of SGPT and SGOT and twenty four adult male rats were divided into four groups : group G0, control group; group G1, a treated group received 0.1 ml sheep red blood cell; group G2, a treated group received 500 mg ethanol extract Pirdot; group G3, a group treated received 500 mg ethanol extract Pirdot and 0,1 ml sheep red blood cell. On thirty one days of treatment, the blood of all rats group were taken to value SGPT and SGOT using DiaLab kit. Furthermore, the molecular docking study was done to analyse molecular interaction that COX-2 and TNF-α were the primary target protein of bioactive compounds of Pirdot associated with hepatoprotective activities. In addition, it tends to be the target of non-steroidal anti-inflammatory drugs such as Ibuprofen. RESULTS: The results show SGOT and SGPT value significantly [p<0.05] decreased on Group G2 and G3. Moreover, the bioactive compounds of Pirdot, such as Pomolic acid and Ursolic acid tend to be the potential compound on liver protection. Moreover, Pomolic acid has a good binding affinity -14.6 kcal mol-1 with COX-2 Protein and the binding affinity of cis-3-O-p-hydroxycinnamoyl Ursolic acid was -15.1 kcal mol-1 associated with TNF-α Protein. CONLUSION: Pirdot Leaves (Saurauia vulcani Korth.) Ethanol Extract showed Hepatoprotective activity in rats (Rattus norvegicus). Molecular docking approach showed that pomolic acid has a good binding affinity with COX-2 Protein and TNF-α Protein.
... The ethanolic and aqueous extracts of T. dioca at different doses, administered orally, showed decrease in the levels of AST, ALT, total bilirubin, ALP and increase in total protein. In vivo hepatoprotective effect of methanolic fruit extract of T. dioica was also evaluated in simvastatin-induced hepatotoxicity in experimental animals (Gupta et al., 2018). The treatment with T. dioca significantly and dose-dependently reversed simvastatin-induced elevation in serum level of SGOT, SGPT, ALP and total bilirubin, and restored the total protein and albumin levels. ...
Cucurbit plants were used actively as traditional herbal remedies for various diseases. The medicinal importance of plants lies in some chemical substances or secondary metabolites that produce a specific physiological action on the human body. Secondary metabolites are non nutritive chemical constituents of plants which are restricted in distribution in the particular plant species. The scarcity of scientific reports of vegetable gourds compared to the traditional usage and folkloric beliefs has further limited us in proper inclusion of cucurbits in our diet and versatile utility. The versatile utility of gourd vegetables as folk medicine and functional food ingredient provoked a compilation of a comprehensive review of these vegetables about their traditional usage and nutritional and medicinal properties together with their phytochemicals. Understanding the nutritional potential of gourd vegetables from scientific reports may influence both the work areas and consumers in the appropriate direction. In this sense, the present chapter aims to provide compilation of references and a detailed overview to the folk medicinal uses of Cucurbita plants. Brief discussion of phytochemicals and its activities are given in the text and for further details, cited references in the text and tables can be consulted.
... 19 The reduced levels of parameters of SOD and CAT, inCCl 4 administered rat but treated with ACE (100, 200, 300) mg/kg group of ACE showed the significant increase in the level of these enzymes, which observed the antioxidant property of ACE oxygen-free radicals. 20 GSH is capable of preventing damage to important cellular components caused by ROS such as free radicals, peroxides, lipid peroxides, and heavy metals 21 The intoxicants with CCl4 causes a reduction in the synthesis and functioning of GSH. The increase in hepatic GSH level in rat treated with 100, 200 and 300 mg/kg of ACE due to de novo GSH synthesis or GSH regeneration. ...
... Silymarin has been used as a standard hepatoprotective drug in this study for comparison of the effect of TD peel extract. Earlier reports showed that TD has been exhibited hepatoprotective effects in simvastatin and ferrous sulphate-induced hepatotoxic rat models [25,26]. On the other hand, the in vitro anti-oxidant activity of the aqueous extracts of TD fruits and leaves has also been welldemonstrated in comparison to the ascorbic acid [27] and quercetin [28]. ...
Plant-derived natural products have shown beneficial effects in many diseases associated with liver. The present study aimed to appraise the effects of Trichosanthes dioica (TD) peel extract on oxidative stress, inflammation as well as fibrosis exhibited by the ovariectomized rats in which hepatic damage had been induced by the administration of carbon tetrachloride (CCl4). The CCl4 administration in the ovariectomized rats elevated the plasma ALT, AST, and ALP level in comparison with the control while TD peel extract showed significant reduction of those activities. Besides, oxidative stress and lipid peroxidation also increased in CCl4-treated rats. TD peel extract significantly reduced the oxidative stress marker’s concentration and improved the catalase and SOD activities in CCl4-administered ovariectomized rats. These results suggest that TD peel extract is capable of protecting the liver from CCl4induced damage through preventing oxidative stress, lipid peroxidation, inflammation, fibrosis and boosting the diminished cellular antioxidant defense.
... Simvastatin (HMG-CoA) reductase inhibitor has been proclaimed to cause acute hepatotoxicity, the projected mechanism for this cause depends on the outcome on cytochrome P-450 system, im-pairment of bile acid transport process, immune mediated inflammatory response to drug or its metabolites, and oxidative stress caused by intracellular damage (Bharadwaj and Chalasani, 2007;Gupta et al., 2018). The enzymes SGOT and SGPT catalyze the transfer of α-amino group from aspar-tate and alanine to α-keto group of ketoglutamic acid to generate oxaloacetic and pyruvic acids, that are vital contributors to TCA cycle (citric acid cycle). ...
Context: Cordia sebestena fruits are traditionally used to treat wounds, boils, tumors, gout, ulcer, flu, fever, asthma, menstrual cramps, dysentery, diarrhea, headache, snakebite and liver disorders. However, information on hepatoprotective potential of Cordia sebestena fruit has not been reported in the research.
Aims: To evaluate the hepatoprotective effect of the ethanolic extract of Cordia sebestena fruit (CSFE) against simvastatin-induced hepatotoxicity in rats.
Methods: After authentication of fruit, its ethanolic extract was collected. Hepatotoxicity was induced by simvastatin in rodents. Hepatoprotective potential of CSFE was evaluated at 200 and 400 mg/kg, body weight by determining the altered levels of biochemical parameters like serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), cholesterol, bilirubin, urea, albumin, total protein and hematological indices including red blood cells (RBC), white blood cells (WBC), hemoglobin (Hb), platelets, and lymphocytes along with the impact on body and liver weight of treated rats.
Results: The treatment with CSFE at 200 mg/kg and 400 mg/kg, significantly at (p
... Simvastatin (HMG-CoA) reductase inhibitor has been proclaimed to cause acute hepatotoxicity, the projected mechanism for this cause depends on the outcome on cytochrome P-450 system, im-pairment of bile acid transport process, immune mediated inflammatory response to drug or its metabolites, and oxidative stress caused by intracellular damage (Bharadwaj and Chalasani, 2007;Gupta et al., 2018). The enzymes SGOT and SGPT catalyze the transfer of α-amino group from aspar-tate and alanine to α-keto group of ketoglutamic acid to generate oxaloacetic and pyruvic acids, that are vital contributors to TCA cycle (citric acid cycle). ...
Resumen Context: Cordia sebestena fruits are traditionally used to treat wounds, boils, tumors, gout, ulcer, flu, fever, asthma, menstrual cramps, dysentery, diarrhea, headache, snakebite and liver disorders. However, information on hepatoprotective potential of Cordia sebestena fruit has not been reported in the research. Aims: To evaluate the hepatoprotective effect of the ethanolic extract of Cordia sebestena fruit (CSFE) against simvastatin-induced hepatotoxicity in rats. Methods: After authentication of fruit, its ethanolic extract was collected. Hepatotoxicity was induced by simvastatin in rodents. Hepatoprotective potential of CSFE was evaluated at 200 and 400 mg/kg, body weight by determining the altered levels of biochemical parameters like serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), cholesterol, bilirubin, urea, albumin, total protein and hematological indices including red blood cells (RBC), white blood cells (WBC), hemoglobin (Hb), platelets, and lymphocytes along with the impact on body and liver weight of treated rats. Results: The treatment with CSFE at 200 mg/kg and 400 mg/kg, significantly at (p<0.05, p<0.001) and dose-dependently reversed simvastatin-induced altered level of SGOT, SGPT, cholesterol, urea, total bilirubin and restored the total protein and albumin level in rodents. Hematological indices also were significantly ameliorated at both the doses of CSFE. Histopathological study revealed the regeneration of hepatocytes. Conclusions: The Cordia sebestena fruit extract (CSFE) at dose of 400 mg/kg reversed liver deteriorations induced by simvastatin in rats, therefore manifesting its traditional use as hepatoprotector. Future studies should be performed for isolating biologically active phytoconstituents. Contexto: Las frutas de Cordia sebestena se utilizan tradicionalmente para tratar heridas, forúnculos, tumores, gota, úlcera, gripe, fiebre, asma, calambres menstruales, disentería, diarrea, dolor de cabeza, mordedura de serpiente y trastornos hepáticos. Sin embargo, no se ha investigado sobre el potencial hepatoprotector de esta fruta. Objetivos: Evaluar el efecto hepatoprotector del extracto etanólico de fruta de Cordia sebestena (CSFE) contra la hepatotoxicidad inducida por simvastatina en ratas. Métodos: Después de la autenticación de la fruta, se realizó su extracto etanólico. La hepatotoxicidad fue inducida por simvastatina en roedores. El potencial hepatoprotector de CSFE se evaluó a 200 y 400 mg/kg, peso corporal determinando los niveles alterados de parámetros bioquímicos como transaminasa oxaloacética glutámica sérica (SGOT), transaminasa piruvica glutámica sérica (SGPT), colesterol, bilirrubina, urea, albúmina, proteína total e índices hematológicos, incluidos los glóbulos rojos (RBC), glóbulos blancos (WBC), hemoglobina (Hb), plaquetas y linfocitos, junto con el impacto en el peso corporal y hepático de las ratas tratadas. Resultados: El tratamiento con CSFE a 200 mg/kg y 400 mg/kg, revertió significativamente, y de manera dependiente de la dosis, los niveles alterados de SGOT, SGPT, colesterol, urea, bilirrubina total inducidos por simvastatina, restaurado los niveles totales de proteína y albúmina en roedores. Los índices hematológicos también mejoraron significativamente (p<0.05, p<0.001) en ambas dosis de CSFE. El estudio histopatológico reveló la regeneración de los hepatocitos. Conclusiones: El extracto de fruta de Cordia sebestena (CSFE) a una dosis de 400 mg/kg protegió del deterioro hepático inducido por simvastatina en ratas, manifestando así su uso tradicional como hepatoprotector. Se deben realizar estudios futuros para aislar fitoconstituyentes biológicamente activos.
... Generally, phytochemicals have been grouped into six main classes including carbohydrates, lipids, phenolics, alkaloids, and terpenoids. The phytochemical compounds are responsible for producing biological effects [5][6][7][8][9][10][11][12][13][14][15] . The phytochemical investigations of Gloriosa superba plant exhibited the presence of carbohydrates, alkaloids, glycosides, flavonoids, steroids, terpenoids and phenolic compounds 16 . ...
