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| Effect of MOS on expression levels of genes related to intestinal barrier functions. Ileum (A) and cecum (B) digesta samples were collected from pigs fed with the basal diet (CON) or a basal diet supplemented with 3 g/kg MOS (MOS) (n = 8). *0.05 < p < 0.1, **p < 0.05.
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Manno-oligosaccharide (MOS) is a prebiotic derived from natural plants or yeasts. Here, we explored the response of intestinal microbiota and epithelial functions after ingestion of MOS in a porcine model. Sixteen pigs were randomly assigned into two treatments and fed with basal or MOS-containing (0.3% MOS) diet for 21 days. Results showed that MO...
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Citations
... 29,30 Because of their chemical structures, they cannot be digested in the small intestine; instead, they are anaerobically fermented by bacteria in the hindgut. 31 This indigestible dietary fiber/carbohydrate fermentation process produces SCFAs (e.g., acetate and butyrate), which have significant positive impacts on intestinal epithelial cell function, 32,33 including the maintenance of metabolism, proliferation, and differentiation; they also promote a low pH in the intestinal environment, which supports beneficial microorganisms and reduces the viability of pathogenic bacteria. 33 The beneficial effects of AgaroS supplementation include anti-diabetic and anti-obesity activities, 32 as well as potential prebiotic activity. ...
Agarose-derived agaro-oligosaccharides (AgaroS) have been extensively studied in terms of structures and bioactivities; they reportedly possess antioxidant and anti-inflammatory activities that maintain intestinal homeostasis and host health. However, the protective...
... This improved mucosal morphology, tight-junction protein distribution, and downregulated genes involved in inflammatory responses and apoptosis, while the expression of antioxidant genes was upregulated [62]. MOS supplementation upregulated the expression levels of tight-junction protein and IGF-1 in the ileum and cecum in porcine model [63]. Use of MOS (0.5%) imparted beneficial effects on accelerating the composting of cow manure by reducing its toxicity and improving the stability of the products [64]. ...
Prebiotic mannooligosaccharides (MOS) are small chains of mannose that are known to confer health benefits to the consumers. At present, commercial MOS are derived by the degradation of yeast cell wall mannans. MOS are also synthesized by the physico-chemical or enzymatic treatment of naturally occurring mannans. Recently, these oligomers are being explored for their role in the modulation of beneficial gut microbiota of animals and their possible usage as functional food ingredients in humans. Experimental evidences strongly point out that dietary MOS impart numerous health benefits including antineoplastic, immunomodulatory, hypolipidemic effects indicating that they have immense potential as a functional food ingredient. In this article we present up-to-date developments related to the production and applications of MOS.
Swine production is important to meeting the needs of a growing human population that consumes greater quantities of animal-derived protein with increasing wealth in certain nations. Common management practices implemented throughout the swine production continuum impact the development of the native gastrointestinal microbial consortia. The swine gut microbial population impacts host animal physiology and health through a series of complex interactions catalyzed by early environmental exposure, the colonization of a complex gut microbial ecosystem, immune system development in which responses are orchestrated to promote whole-organism homeostasis, and, ultimately, the efficient production of high-quality pork. We discuss recent changes in our understanding of how direct-fed microbial supplementation benefits swine and pork producers. Further, we have increased our recognition of how much information we lack on understanding how the native microbial population impacts growth performance and how direct-fed microbial supplements can be used as tools for reaching swine’s genetic potential for efficient production. Specifically, our challenge is to identify bacterial strains that elicit defined responses in the host such that the future of direct-fed microbial (eubiotic) supplementation to swine diets will be tailored to provide the most benefit to the pig at various production stages or administered as a prescription to address the specific needs of a complex global swine production system.
