Figure 3 - uploaded by Dominic Gabriel Iliescu
Content may be subject to copyright.
Source publication
![Figure 4: Isolated encephalocele in the first trimester. 2D axial [A]...](profile/Dominic-Iliescu/publication/322597986/figure/fig3/AS:584505396056064@1516368354256/Isolated-encephalocele-in-the-first-trimester-2D-axial-A-and-sagittal-B-views-at-12_Q320.jpg)
Contexts in source publication
Context 1
... high percentage (89%) of fetuses with acrania has echogenic amniotic fluid and this finding could potentially be used as a marker of fetal acrania in the first trimester (Figure 3) [28]. This also supports the hypothesis of the transition from acrania to anencephaly, with the unprotected brain undergoing progressive destruction. The prognosis of anencephaly is gloomy, as this disorder is incompatible with life, therefore termination of pregnancy is recommended and feasible at this gestational ...
Context 2
... high percentage (89%) of fetuses with acrania has echogenic amniotic fluid and this finding could potentially be used as a marker of fetal acrania in the first trimester (Figure 3) [28]. This also supports the hypothesis of the transition from acrania to anencephaly, with the unprotected brain undergoing progressive destruction. The prognosis of anencephaly is gloomy, as this disorder is incompatible with life, therefore termination of pregnancy is recommended and feasible at this gestational ...
Similar publications
Citations
... The FTAS routine assessment has two primary objectives in obstetric practice: evaluation of sonographic genetic markers that increases the accuracy and sensitivity of detecting chromosomal abnormalities and early detection of congenital anomalies [1][2][3]. ...
... In the FT mid-sagittal plane of the fetal head, when measuring the nuchal translucency and assessing the ossification of the nasal bone and fronto-maxillary facial angle [1], some CNS secondary features of OSB are apparent [13]. No additional time is needed for OSB indirect markers assessment because nuchal translucency measurement and nasal bone evaluation are mandatory at this gestational age. ...
... No additional time is needed for OSB indirect markers assessment because nuchal translucency measurement and nasal bone evaluation are mandatory at this gestational age. Sonographic screening markers of the posterior brain in OSB include a non-measurable, a decreased or absent CM, a thickened BS, and an increased BS/BSOB ratio of more than 1 [1,49,50]. In this study, 66.6% of cases of OSB (two/three cases) associated with absent IT. ...
Objective:
To evaluate the potential of the first-trimester ultrasound (US) features for the detection of central nervous system (CNS) anomalies. Methods/Methodology: This is a prospective one-center three-year study. Unselected singleton pregnant women were examined using an extended first-trimester anomaly scan (FTAS) that included the CNS assessment: the calvaria shape, the septum (falx cerebri), the aspect of the lateral ventricles, the presence of the third ventricle and aqueduct of Sylvius (AS) and the posterior brain morphometry: the fourth ventricle, namely intracranial translucency (IT), brain stem/brain stem-occipital bone ratio (BS/BSOB) and cisterna magna (CM). The spine and underlying skin were also evaluated. The cases were also followed during the second and third trimesters of pregnancy and at delivery. FTAS efficiency to detect major CNS abnormalities was calculated.
Results:
We detected 17 cases with CNS major abnormalities in a population of 1943 first-trimester (FT) fetuses, including spina bifida with myelomeningocele, exencephaly-anencephaly, holoprosencephaly, hydrocephaly, cephalocele and Dandy-Walker malformation. The CNS features in the abnormal group are presented. In the second trimester (ST), we further diagnosed cases of corpus callosum agenesis, cerebellar hypoplasia, vein of Galen aneurysm and fetal infection features (ventriculomegaly, intraventricular bands, intraventricular cyst and hyperechoic foci), all declared normal at the FTAS. During the third trimester (TT) scan we identified a massive fetal cerebral haemorrhage absent at previous investigations. We report a detection rate of 72.7% of fetal brain anomalies in the FT using the proposed CNS parameters. The sensitivity of the examination protocol was 72.7%, and the specificity was 100%.
Conclusion:
A detailed FT CNS scan is feasible and efficient. The majority of cases of major CNS abnormalities can be detected early in pregnancy. The visualization rates of the CNS parameters in the FT are great with short, if any, additional investigation time. FT cerebral disorders such as haemorrhage or infections were missed in the FT even when an extended evaluation protocol was used.
