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Traditionally, the assessment of endometrial receptivity at transvaginal ultrasound scan has been based on the thickness and the morphological appearance of the endometrium. The objective of this study was to prospectively evaluate endometrial thickness (ET), endometrial morphology and uterine artery Doppler parameters prior to assisted reproductio...
Context in source publication
Context 1
... (14.3 vs. 3.4%; p ¼ 0.30) respectively in the pregnant and not pregnant groups Furthermore, there were no differences in mean ± SD UtAD RI between the pregnant and not pregnant groups (0.84 ± 0.10 vs. 0.81 ± 0.10; p ¼ 0.30) ( Table 3). These findings were similar, when analysed by fresh cycles only (Table 4), women with no prior ART cycle (Table 5) and those with unexplained infertility (Table 6). When analysed by fertility aetiology (endometriosis, male factor, unexplained infertility), there were no differences in mean PI (Figure 1) or RI (Figure 2) between the groups ( ...Similar publications
Purpose
To evaluate the impact of serum LH levels prior to progestin administration on the outcomes of programmed frozen-thawed embryo transfer (FET) cycles.
Methods
Retrospective cohort study was conducted to compare the treatment outcomes between four groups based on the 25 percentiles of serum LH levels before progestin administration in 596 cy...
Citations
... Ultrasonography has been used to investigate a number of potential markers of endometrial receptivity such as subendometrial blood flow patterns and endometrial volume [1][2][3]. However, the most widely studied and preferred methods are endometrial thickness (EMT) and pattern, sometimes with conflicting results [4][5][6][7]. ...
Endometrial compaction (EC) is defined as the difference in endometrial thickness from the end of the follicular phase to the day of embryo transfer (ET). We aimed to determine the role of EC in predicting assisted reproductive technology (ART) success by conducting a meta-analysis of studies reporting the association between EC and clinical outcomes of ART.
MEDLINE via PubMed, Web of Science, Scopus, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from the date of inception to May 19, 2023. The primary outcome was live birth rate (LBR) per ET. Secondary outcomes were live birth or ongoing pregnancy per ET, ongoing pregnancy per ET, clinical pregnancy per ET, and miscarriage per clinical pregnancy.
Fifteen studies were included. When data from all studies reporting live birth were pooled, overall LBR rates were comparable in cycles showing EC or not [RR = 0.97, 95%CI = 0.92 to 1.02; 10 studies, 11,710 transfer cycles]. In a subgroup of studies that included euploid ET cycles, a similar LBR for patients with and without EC was noted [RR = 0.99, 95%CI = 0.86 to 1.13, 4 studies, 1172 cycles]. The miscarriage rate did not seem to be affected by the presence or absence of EC [RR = 1.06, 95%CI = 0.90 to 1.24; 12 studies].
The predictive value of EC in determining LBR is limited, and assessment of EC may no longer be necessary, given these findings.
PROSPERO CRD42023410389
... Baseline characteristics and quality assessment of the included studies. In total, 14 cohort studies were included in the present meta-analysis (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29). The combined patient sample size was 4,842. ...
At present, there are currently no reliable and consistent conclusions regarding transvaginal ultrasound assessment of endometrial receptivity in predicting clinical pregnancy outcomes of in vitro fertilization-embryo transfer (IVF-ET). Thus, in the present study, a meta-analysis was performed on multiple endometrial receptivity indices detected by vaginal ultrasound, aiming to provide a diagnostic basis for clinical practice. PubMed, Embase, and Cochrane Library databases were searched for studies published between the establishment of the databases through to January 2023. Studies that reported infertile women undergoing IVF-ET and undergoing vaginal ultrasound were included, but repeat publication, studies where the full text was not obtainable, studies where there was incomplete information provided or data extraction was not possible, studies on animals, case reports, reviews, and systematic reviews were excluded. STATA 15.1 was used to analyze the data. The pooled results showed that the endometrial thickness [Weighted mean difference (WMD)=0.03, 95% CI: 0.00-0.06; P=0.022] and endometrial volume (WMD=0.41, 95% CI: 0.07-0.74; P=0.017) of the pregnancy group after receiving IVF-ET were all significantly higher than that of the non-pregnancy group. The pooled results also showed that the vascularization index (VI) (WMD=0.79, 95% CI: 0.56-1.03; P=0.000), flow index (FI) (WMD=1.82, 95% CI: 0.83-2.81; P=0.000) and vascularization flow index (VFI) (WMD=1.58, 95% CI: 0.91-2.24; P=0.000) of the pregnancy group after receiving IVF-ET was significantly higher than that of the non-pregnancy group. Systolic/diastolic (S/D) (WMD=-4.92, 95%CI: -8.28- -1.56; P=0.004) of the uterine artery of the pregnancy group after receiving IVF-ET was significantly lower than that of the non-pregnancy group. However, the differences between the resistance index (RI) and pulsatility index (PI) in the pregnancy group vs. the non-pregnancy group after receiving IVF-ET were not statistically significant. Vaginal ultrasound can be used to predict the outcomes of pregnancy in infertile women undergoing IVF-ET by measuring the thickness and volume of the endometrium, combined with the S/D, VI, FI, and VFI of the uterine artery.
... However, Zhang and colleagues 9 reported that there was no significant association between outcome with infertility duration or type of infertility. Also, Crosby and colleagues 11 reported that there was no significant association between outcome with infertility duration or menstrual cycle length. The disagreement with our results may be attributed to the difference in sample size and inclusion criteria. ...
... Numerous methods have been suggested in the literature to assess endometrial receptivity. These methods include measuring the endometrial thickness (ET), evaluating endometrial pattern, endometrial receptive analysis (ERA), estimating endometrial perfusion, and uterine artery Doppler (3,4). An endometrial receptive analysis is a costly and invasive method. ...
Background:
The implantation rate after assisted reproductive technology depends on 2 important factors, good quality embryo and endometrial receptivity. Endometrial receptivity is mainly assessed by ultrasound measurement of endometrial thickness and morphology.
Objective:
This study aimed to investigate the relationship between uterine artery Doppler indices/endometrial perfusion and pregnancy rate.
Materials and methods:
This cohort study was done on 250 women who were candidates for frozen embryo transfer from January to July 2022. For assessing endometrial receptivity, we performed a Doppler ultrasound of the uterus before embryo transfer with apparently desirable endometrium (endometrial thickness ≥ 7 mm and 3 line endometrial pattern). In addition, the women were divided into 2 groups according to assisted reproductive technology outcome (clinical pregnancy), group I positive clinical pregnancy, and group II negative clinical pregnancy, and uterine artery indices and endometrial perfusion were compared between these groups.
Results:
Uterine artery Doppler showed that the pulsatility index was significantly different between positive and negative clinical pregnancy groups, but resistance index and peak systolic velocity (PSV) did not have statistically significant differences. Also, endometrial perfusion was significantly different between the 2 groups of clinical pregnancy. Endometrial perfusion was significantly better in positive clinical pregnancy groups.
Conclusion:
Doppler ultrasound can help to assess endometrial receptivity.
