Figure 2 - uploaded by Jim Graham
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Distributions of the 15 b-values representing chromosome 11. The earlier b-values represent greater proportions of variability than the later ones. Crosses represent control data and circles test data. Both test data sets represent deletions of known size, 14-18 Mbp (a) and 3Mbp (b).
Source publication
We have applied the method of statistical shape modelling to fluorescence ratio profiles from CGH images. The models are built from a training set of control profiles. Principal Component Analysis is used to extract the most significant modes of variation of the shape. The variability of the training set is expressed in terms of a weighted combinat...
Context in source publication
Context 1
... for normal test profiles were also calculated for chromosomes 4, 5, 11, 18, 15 and 22. Details of the normal and abnormal test sets are shown in table 1. Figure 2 shows the distribution of b-values for two abnormal sets of chromosome 11 profiles (a 14-18Mbp deletion and a 3Mbp deletion ), compared with the controls. PCA ranks the parameters in order of the proportion of variability they represent; b 1 controls the most significant mode of variation, b 2 the next and so on. ...
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The testing of high-dimensional normality is an important issue and has been intensively studied in the literature, it depends on the variance–covariance matrix of the sample and numerous methods have been proposed to reduce its complexity. Principle component analysis (PCA) has been widely used in high dimensions, since it can project high-dimensi...
