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Distribution of ROP staging in both eyes of the screened infants (total screened infants n = 276, ROP diagnosed n = 133)
Source publication
Background
The third epidemic of retinopathy of prematurity (ROP) has majorly involved middle income countries in which tailored screening and local guidelines require development. The data regarding ROP prevalence and cutoff numbers for screening in Egypt are lacking.
Methods
Retrospective analysis of an independent screening effort spanning 2 ye...
Context in source publication
Context 1
... vitreoretinopathy (based on an elder sibling's history of the disease that had been confirmed by genetic testing abroad) with bilateral total retinal detachments, the infant was referred for genetic testing abroad due to its local unavailability, and for surgical intervention. One hundred and thirty-three infants (48.2%) had some form of ROP (Fig. 1) that was bilateral in 127 (95.5%) of them. Plus disease was detected in at least 1 eye of 33 infants (12%), while AP-ROP was detected in both eyes of 24 infants (8.7%). In infants with ROP, the male/female distribution was 73/60 (1.2:1), the median (IQR) GA was 32 (30-34) weeks, and the median (IQR) BW was 1600 (1350-2000) ...
Citations
... Supplementary Table 2 shows data of each of the 139 included studies ( 5 , 7 , 18-154 ), in which a total of 121,618 premature infants were analyzed. The oldest reports were published in 1988 ( 18 , 19 ), and the most recent reports were published in 2021 (141)(142)(143)(144)(145)(146)(147)(148)(149)(150)(151)(152)(153)(154). Most of the 139 articles included were retrospective studies ( n = 69, 49.6%); 33% ( n = 46) were prospective studies; 7.9% ( n = 11) were cross-sectional studies; and 9.3% ( n = 13), did not report the study design. ...
... Further, rural regions within the country are likely to be inflicted by more severe forms of the disease due to lower standard of care. 13 The discrepancy in the criteria used for screening and in regional conditions of neonatal care, together with the small sample sizes, result in wide variability in reporting and indefinite conclusions. ...
... The incidence rates of ROP and of high-risk disease were comparable to national and international rates, although occurrence of treatmentrequiring disease was significantly less than in a large recent study from a rural setting. 13 This exploratory study can serve in tailoring local criteria for ROP screening, and in the future development of national guidelines. With national plans for digitalization of the healthcare system, easier documentation and referral of infants that require screening could be expected, and a greater contribution of telemedicine could limit the proportion of missed screening encounters. ...
Background:
Retinopathy of prematurity (ROP) is increasing in incidence in developing nations, including Egypt. Secondary prevention requires timely detection through the development of regional screening guidelines, which should be preceded by large-scale studies to characterize the population at risk.
Methods:
A prospective, multicentric exploratory study that included five large tertiary institutions in an urban Egyptian setting. All infants born with gestational age (GA) < 37 weeks and/or birth weight (BW) ≤ 2000 grams were screened. More mature and heavier infants with unstable clinical course were also included. The primary outcome measure was the rate of ROP and high-risk disease occurrence in relation to underlying risk factors.
Results:
Of the 768 eyes (384 screened infants), 347 eyes (45.2%) had stage 1 or higher disease, and 43 eyes (5.6%) had high-risk disease. Eyes with stage 1 or higher ROP and treatment-requiring ROP had a mean (± SD) GA of 33.4 (± 2.6) weeks and 32.8 (± 3.2) weeks, and BW of 1842.3 (± 570.1) grams and 1747.6 ± (676.2) grams, respectively. Treatment-requiring eyes belonged to infants that had significantly lower GA and significantly higher prevalence of co-morbidities than non-treatment-requiring eyes.
Conclusion:
The incidence of ROP and high-risk disease in an urban Egyptian setting are similar to those in comparable settings elsewhere and locally. This exploratory study supports tailoring local screening criteria for ROP, and may aid the future development of national guidelines.
... The factors of ROP-like lesions are similar with those of premature infants. That is, oxygen supply, low birth mass, multiple births, etc., which can make irreversible visual impairment [12][13][14] . Why the incidence of ROP-like in NICU was signi cantly higher than in the control group was perhaps mainly associated with a history of oxygen inhalation of the three children. ...
Objective: To compare and analyze the differences in the results of neonatal ocular diseases screening in the Intensive Care Unit, and the Mother-infant ward in the same room of a general hospital.
Methods: The eye screening data of newborns were collected in Zhongshan City People's Hospital, from December 2018 to December 2021, using a digital wide-field fundus imaging system (RetCam3). The neonates were divided into Neonatal Intensive Care Unit group (NICU) and Mother-infant Ward group (Control Group) according to the ward in which the neonates were located. The differences in the results between the two groups were analyzed in the same manner. Results: A total of 7239 neonates completed eye examinations, of which 1200 (16.58%) had abnormal eyes. In the Control Group 5481 cases were screened. The result showed that 1000 cases (18.24%) with ocular abnormalities; 976 cases (17.80%) with retinal hemorrhage; and 24 cases (0.44%) with other abnormalities. 1758 cases in the NICU group were screened. Out of which 200 cases with ocular abnormalities (11.37%), 165 cases (9.38%) of retinal hemorrhage, 19 cases (1.10%) of retinopathy of prematurity (ROP), 6 cases of ROP were treated with intravitreal injection, and 16 cases (0.91%) of other abnormalities.
Conclusion: The rate of retinal hemorrhage was significantly lower in the NICU group than in the Control Group, but other congenital ocular abnormalities accounted for greater proportion of children in the NICU group. General newborn screening is conducive to the early detection and treatment of various eye diseases, reducing the missed diagnosis of eye diseases. For high-risk neonates in the NICU group, eye disease screening is more imperative.
... 28 Other smaller scale studies reported that the prevalence of ROP ranged between 19.2% 29 and 48.2%. 30 ROP changes more than stage 0 were more prevalent in infants with lower GA and birth weight, with mean GA of affected infants around 31 weeks (30.78 ± 2.29) and mean BW around 1450 g (1452.90 ± 404.41). ...
Purpose:
To evaluate the retinopathy of prematurity (ROP) prevalence, risk factors and screening outcome in a tertiary hospital in Cairo, Egypt.
Methods:
A prospective observational study was done in Neonatal Intensive Care Unit in Ain Shams University Hospital. A total of 159 premature infants were screened for ROP based on the most inclusive criteria reported to date. Screening included premature infants with gestational age (GA) of ≤34 weeks or birth weight (BW) of ≤2000 grams, or GA >34 weeks or BW >2000 grams, with multiple co-morbidities. The prevalence of ROP, plus disease and their correlation with risk factors of interest were studied.
Results:
The GA of the included infants ranged from 27 to 36 weeks, mean (SD) 31.87 (± 1.81) weeks. The BW ranged from 640 to 3900 grams, mean (SD) 1784.71 (± 560.30) grams. The prevalence of ROP more than stage 0 was 25.8% (41 infants), 7.3% of the cases (11 infants) showed plus disease and 6.3% (10 infants) showed severe ROP requiring treatment. Of those, 2 cases (20%) fell outside the British Guideline's criteria for Screening. There was a highly significant (p < 0.0001) correlation between ROP more than stage 0 and low GA, low BW, mechanical ventilation, respiratory distress syndrome, necrotizing enterocolitis, intraventricular haemorrhage, and blood transfusion. No significant correlation was found between appearance of ROP more than stage 0 and gender (p = 0.911), patent ductus arteriosus (p =0.187), or sepsis (p =0.998).
Conclusion:
ROP is a significant problem in the premature infants in Egypt. Extremely premature infants with lower BW are more prone to develop ROP. However, cases with higher GA and BW than mentioned in the British guidelines screening criteria especially with multiple comorbidities showed severe ROP requiring intervention, which implies the need to develop a screening guideline for the Egyptian population.
Background: Retinopathy of Prematurity is a multi-factorial preventive cause of childhood blindness. Using POINTS of care as preventive strategies may be significantly prevent occurrence of retinopathy of premature neonates. The aim of the study was to evaluate nurses' performance regarding points of care for prevention of retinopathy of premature neonates. Subjects and Method: The study design used was descriptive. Setting: It was conducted at Neonatal Intensive Care Units of Tanta Main University Hospital & International Teaching Hospital. Subjects: All nurses (120) who are working in the aforementioned places. Tools: two tools were used: Tool I: Retinopathy Structured Interview Questionnaire, Tool II: POINTS of Care Observational Checklists. Results: nearly three quarters of the nurses had low level of overall knowledge about retinopathy of prematurity and POINTS of care. More than half of the nurses had unsatisfactory practice regarding POINTS of care. Conclusion: Nurses had low level of knowledge & unsatisfactory practice about retinopathy of prematurity and POINTS of care. Recommendations: Designing a training course for neonatal nurses concerning retinopathy of prematurity. Applying POINTS of care standardized protocol for prevention of retinopathy of premature neonates at neonatal intensive care units.
