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Source publication
Background: The study's primary aim was to determine the variation in the thyroid profile status in children with newly diagnosed seizure disorders started on first-line antiepileptic drugs. In addition, this study compares the incidence of hypothyroidism secondary to phenytoin, phenobarbitone, valproate and carbamazepine. Methods: A total of 60 ch...
Context in source publication
Context 1
... the study, 15% (9) of the children had developmental delays, and the remaining 85% (51) had normal development, as shown in Table 3. Family history was present in 3.3% (2), and the remaining 96.7% (58) had no relevant family history, as seen in Table 4. Out of sixty participants, microcephaly was present in 16.7% of the subjects, and the remaining 83.3% had no microcephaly, as shown in Table 5. Table 6 shows the various drugs used in the study, where 55% were given phenytoin, 38.3% were given sodium valproate and 6.7% were given carbamazepine. ...Similar publications
Background:
Antiseizure drug valproate alters thyroid functions. Magnesium is implicated in the pathogenesis of epilepsy and it may affect the efficacy of valproate and thyroid functions.
Objective:
To study the effect of six months of valproate monotherapy on thyroid functions and serum magnesium levels. To study the association among these lev...
