Differential diagnosis in cholestatic syndrome. This figure shows the different entities included in the differential diagnosis of cholestasis in clinical practice. Viral hepatitis A and E are the hepatotropic viruses that typically cause cholestatic alteration. Created in BioRender.com. PBC: primary biliary cholangitis; PSC: primary sclerosing cholangitis

Differential diagnosis in cholestatic syndrome. This figure shows the different entities included in the differential diagnosis of cholestasis in clinical practice. Viral hepatitis A and E are the hepatotropic viruses that typically cause cholestatic alteration. Created in BioRender.com. PBC: primary biliary cholangitis; PSC: primary sclerosing cholangitis

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Drug-induced liver injury (DILI) is an adverse reaction to drugs and other xenobiotics that can have serious consequences and jeopardise progress in pharmacological therapy. While DILI is predominantly hepatocellular, a non-negligible percentage of patients who present with cholestatic damage. Mixed damage is typically lumped together with cholesta...

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Context 1
... cholestasis diagnosis based on the thorough exclusion of all possible potential causes of cholestasis (Figure 1). This approach requires an accurate medical history, a proper clinical assessment, and a stepwise analysis of the pattern of biochemical alterations and other complementary tests. ...