Figure 4 - uploaded by Laura Avagliano
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Different body levels of fetal vertebrae sections. Different appearances of normal transverse sections of vertebrae and spinal cords through the column, according to the body level from cranial to caudal. Failure of closure of the developing neural tube results in open neural tube defects (such as spina bifida and exencephaly) that can affect different levels of the neural tube length, normally reflecting the site where closure should have been completed. Indeed, craniorachischisis (i.e. open brain from the cervical region) reflects failure of the first closure site (Figure. 5), anencephaly (i.e.
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Central nervous system development is a dynamic and multistep process that occurs early during embryonic life. Failure of neural tube closure results in a birth defect known as neural tube defect, a condition that might present in different forms, from mild to severe. Depending on where and when the impairment occurs, the clinical outcomes will var...
