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We have developed novel series of 5-arylidene-1, 3-thiazolidin-4-one analogues using diethylamine as catalyst. Diethylamine was found suitable in synthesizing variety of title compounds in 62-85% yield. In-vitro anticancer activity of synthesized analogues was evaluated using human breast (MCF7), lung (Hop62) and hepatic (HepG2) cell lines using SR...
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Context 1
... various substituted benzaldehydes 4a-4f were reacted with 3a-3f and 8a-8f, using diethylamine by optimized reaction conditions to form 5a-5f and 9a-9f respectively. The results are summarized in Table 2. It was observed that diethylamine is suitable catalyst in synthesizing 5a-5f and 9a-9f series of compounds. ...Context 2
... various substituted benzaldehydes 4a-4f were reacted with 3a-3f and 8a-8f, using diethylamine by optimized reaction conditions to form 5a-5f and 9a-9f respectively. The results are summarized in Table 2. It was observed that diethylamine is suitable catalyst in synthesizing 5a-5f and 9a-9f series of compounds. ...