Fig 1 - uploaded by Jeong Hoon Pan
Content may be subject to copyright.
Dietary Houttuynia cordata extract decreases weight gain without influences in food intake in rats fed high-fat diet. Animals were fed normal diet or HFD with HCE supplementations at 1 or 5% for 8 weeks. Weight gain (A) and food intake for 8 weeks (B). All data are shown as the mean±SE (n=8-9). # Significantly different from ND control (p<0.05).
Source publication
The purpose of this study was to evaluate the effects of ethanolic extracts from Houttuynia cordata on the serum lipid profile and hepatic lipid peroxidation in rats. Animals were fed either a normal or high-fat diet (HFD) containing 0, 1 or 5% H. cordata extracts for 8 weeks. Dietary supplementation of H. cordata extracts at 1 and 5% normalized th...
Similar publications
Houttuynia cordata is an herbal plant rich in polysaccharides and with several pharmacological activities. Human noroviruses (HuNoVs) are the most common cause of foodborne viral gastroenteritis throughout the world. In this study, H. cordata polysaccharide (HP), with a molecular weight of ~43 kDa, was purified from H. cordata water extract (HWE)....
Objective: The present study was designed to evaluate the anti-obesity efficacy of ethanol extract of roots of Stereospermum suaveolens on high fat fed obese rats. Methodology: Ethanol extract of roots was prepared by hot extraction method and preliminary phytochemical studies had been conducted. Obesity was induced in Wistar rats by administration...
Objective. The whole plant of Houttuynia cordata has been reported to have potent antihyperglycemic activity. Therefore, the present study was undertaken to investigate the glucose utilization capacity of bioactive fractions of ethanol extract of Houttuynia cordata (HC) in isolated rat hemidiaphragm. Methods. All the fractions, that is, aqueous (AQ...
Citations
... Relevant to this finding, it has been demonstrated that H. cordata plant extract (HTE) (1%) was shown to reduce the serum levels of TG, cholesterol, and LDL in rats fed with a high-fat diet but did not affect the HDL cholesterol level (Tunkamnerdthai et al., 2019). In addition, ethyl acetate extract of H. cordata (HC-EA extract) also showed significantly reduced TG, TC, and LDC-c in high-fat diet-fed rat by downregulation of lipid accumulation in the plasma (Kang & Koppula, 2015;Kim et al., 2014). Thus, the effect of HCFP on the reduction of lipid levels was an interesting finding although this study did not restrict the food consumption for all volunteers. ...
Houttuynia cordata Thunb. fermentation product (HCFP) is widely used in Thailand as a dietary supplement for immune support with no experimental verification. The aims of this study were to investigate the safety and immunomodulation of HCFP in healthy volunteers and to study its effect on antiretroviral drugs in Sprague Dawley rats. The basic characteristics and blood chemistry of 10 healthy volunteers did not show any significant differences between before and after 4 weeks of intervention with a daily intake of HCFP, and no major adverse event was observed. The immunomodulation study revealed that the percentage of neutrophils was significantly increased after 8 weeks of intervention in 30 healthy volunteers. The CD4⁺:CD8⁺ T cell was increased from 1.24 ± 0.49 to 1.29 ± 0.56 with no significant difference. The plasma concentrations of EFV and TDF in Sprague Dawley rats showed no significant difference between the single drug group and combination with HCFP group.
... Immunomodulatory activity-Water extract/ethanol extract/polysaccharides possessed immunomodulatory effects on the vaginal mucosa ( Satthakarn et al., 2015), PBMCs ( Cheng et al., 2014), LPS-activated macrophages ( Kim et al., 2009), mouse splenic lymphocytes ( Lau et al., 2008), Jurkat T cells and HMC-1 human mast cell line ( Lee et al., 2008), mast cell-mediated anaphylactic responses ( Li et al., 2005). Protective effects (continued on next page) Water extract showed protective effect against high saturated fat diet-induced obesity and oxidative and inflammatory injury in mice ( Lin et al., 2013), prevent lung injury from LPS stimulation in rats ( Cai et al., 2013), cardiac and renal injury and oxidative stress under diabetic condition in mice ( Hsu et al., 2016a), and ethanol extract also reduced atherogenic risk and hepatic oxidative damage induced by high saturated fat diet in rats ( Kim et al., 2014 Cytotoxicity to cancer cells-Water extract and its fraction inhibited cell proliferation and induced apoptosis in RKO colon cancer cells ( Tansuwanwong et al., 2009). Antimutagenic activity-Hispidulin and hortensin showed antimutagenic activity against 2-aminoanthracene, aflatoxin Bl, and dimethylnitrosamine, while showed no mutagenicity and no cytotoxicity toward S. typhimurium strains TA98 and TA100 ( Chulasiri et al., 1992 Mareng could be prevented by changing habits; no stress. ...
Ethnopharmacological relevance:
Thai traditional medicine (TTM) is widely practiced in Thailand and continues to gain importance in cancer management, but little is known about the TTM practitioners' emic concepts and practice.
Aim of the study:
With this study we firstly aim to document the practice of cancer treatment and prevention by TTM practitioners and, secondly, to evaluate how such traditional concepts and practices are correlated with biomedical ones. This in turn can form the basis for developing novel strategies for designing pharmacological experiments and longer term strategies to develop TTM practice.
Methods:
Semi-structured interviews with 33 TTM practitioners were performed in five provinces in different regions of Thailand. The following information were recorded; basic information of informants, descriptions of cancer (mareng in Thai), causes, diagnosis, treatment, and prevention. Plants used in the treatment and prevention of mareng were also collected.
Results:
Using an in depth ethnographic approach four representative case studies to assist in a better understanding of the characteristics of mareng, its diagnosis, treatment, and prevention are reported here. Five characteristics of mareng - waste accumulation (khong sia), chronic illnesses (krasai), inflammation (kan aksep), bad blood (luead) and lymph (namlueang), and the imbalance of four basic elements (dhātu si) - have been identified. Explanatory models of cancer in TTM were linked with biomedical concepts and relevant pharmacological actions. Traditional uses and available scientific evidence of medicinal plants mentioned in the case studies for the treatment or prevention of mareng are presented and discussed.
Conclusion:
Here for the first time five main characteristics of cancer based on Thai traditional medical concepts are analysed. Our findings are relevant not only for the planning of clinical studies or pharmacological experiment in the search for novel compounds for cancer treatment and prevention, but also for the integration of Thai traditional medicine in cancer care.
... Three other flavonoids, rutin, hyperin and quercitrin were isolated from H. cordata by Peng et al. [38]. Reported biological activities of the extracts of H. cordata include antiatherogenic, antioxidative [39], antihyperglycemic [40], anti-dengue [41], anti-neuroinflammatory [42], antioxidant [43] and antimicrobial properties [44]. Thus, the traditional antiinflammatory effect of H. cordata has been supported scientifically; however, scientific evidence for other traditional uses has not yet been found. ...
... The roots and rhizomes of A. kravanh are believed to promote digestion and to be effective against dyspnea. Fruits of this plant have been reported to contain (7S)-p-cymene-2,7,8-triol, (3R,4R,6S)-p-menth-1-ene-3,6,10-triol [95], kravanhol A, kravanhol B, the diarylheptanoid, renealtin A [96], kravanhins A-D (39)(40)(41)(42), three new labdane diterpenes [97], -carene, thujone, α-terpineol,and 4-terpinenol [98]. According to Tsuge et al., the seeds contain methylcholest-4-ene-3,6-dione, stigmasta-4,22-diene-3,6-dione and stigmast-4-ene-3,6-dione [99]. ...
... Lung tonic, antipyretic, anti-inflammatory, antidote, nephritis and cough Antiatherogenic and antioxidant [39], antihyperglycemic [40], anti-dengue [41], anti-neuroinflammatory [42], antioxidant [43], antimicrobial [44] properties Osmanthus fragrans Lour. Oleaceae ...
Medicinal plants are a vital source of medication in developing countries. In Kachin State, Northern Myanmar, the people have a long history of the use of traditional plants for medicinal purposes. This article deals with the 25 most used medicinal plants in Kachin State. They are: Drynaria fortunei, Tetrastigma serrulatum, Bauhinia championii, Goniothalamus cheliensis, Juglans regia, Houttuynia cordata, Osmanthus fragrans, Pothos chinensis, Tabemaemontana coronaria, Eryngium foetidum, Chloranthus spicatus, Peperomia pellucida, Zanthoxylum armatum, Polygonum fagopyrum, Cymbidium floribundum, Amomum kravanh, Coscinium fenestratum, Solanum nigrum, Gnetum parvifolium, Desmodium triquetum, Begonia augustinec, Mappianthus iodoides, Erycibe obtusifolia, Schefflera venulosa, Holarrhena antidysenterica. The different traditional applications, the known chemical constituents and medicinal properties are reported for each plant. The efficacy of several of these plants has been supported by some scientific evidence, while other plants have to be submitted to further investigations to prove the beneficial medicinal properties attributed to them.
Houttuynia cordata Thunb is rich in active substances and has excellent antioxidant and anti-inflammatory activity. Scanning electron microscopy and gel permeation chromatography were used to analyze the molecular characteristics of the fermentation broth of Houttuynia cordata Thunb obtained through fermentation with Clavispora lusitaniae (HCT-f). The molecular weight of HCT-f was 2.64265 × 105 Da, and the polydispersity coefficient was 183.10, which were higher than that of unfermented broth of Houttuynia cordata Thunb (HCT). By investigating the active substance content and in vitro antioxidant activity of HCT-f and HCT, the results indicated that HCT-f had a higher active substance content and exhibited a superior scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals and hydroxyl radicals, with IC50 values of 11.85% and 9.01%, respectively. Our results showed that HCT-f could effectively alleviate the increase in the secretion of inflammatory factors and apoptotic factors caused by lipopolysaccharide (LPS) stimulation, and had a certain effect on repairing skin barrier damage. HCT-f could exert an anti-inflammatory effect by down-regulating signaling in the MAPK/NF-κB pathway. The results of erythrocyte hemolysis and chicken embryo experiments showed that HCT-f had a high safety profile. Therefore, this study provides a theoretical basis for the application of HCT-f as an effective ingredient in food and cosmetics.
Cancer chemoprevention aims to prevent, delay, or reverse carcinogenesis. Thai Traditional Medicine (TTM) could be a source for cancer chemopreventive agents and – more broadly –could play a role in cancer prevention. Using an ethnopharmacology approach this thesis aims to understand the pharmacological basis of some of these botanical drugs and to discover new extracts which could be useful in cancer prevention. Interviews with 33 TTM practitioners revealed the five characteristics of cancer in TTM (mareng), which is described as an accumulation of waste, chronic inflammation, chronic illnesses (krasai), bad condition of body fluids (‘luead’ and ‘namlueang’), and imbalance of dhātu si. Further analysis of preventive methods led to the five strategies for preventing mareng. To link TTM actions to pharmacology, we proposed that three strategies, removal of waste, liver protection, and prevention from krasai, can be linked to the antioxidant system. After screening of fifty-two extracts, fifteen exhibited protective effect in a liver cancer cell line. Among them, ethanol extracts of Thunbergia laurifolia leaves (TLe) and Senegalia rugata leaves (SR1e) exhibited the most potent activities in the induction of NQO1 enzyme and glutathione. Upregulation of antioxidant genes and radical scavenging were among their protective mechanisms. While TLe induced NQO1 expression, SR1e upregulated the expression of Nrf2. Both extracts did not induce CYP1A1 expression nor reduce cell viability of primary rat hepatocytes which provided preliminary safety profile. Using HPLC-HRMS-SPE-ttNMR, we could identify some active constituents in the extracts. This is the first report analysing how cancer is perceived in TTM, what prevention strategies are used, linking this to pharmacological models, and on chemopreventive properties of TLe and SR1e and some of their constituents. The evidence supports the potential use of these medicinal plants in cancer prevention. Future work should be performed with more TTM practitioners and use in vivo models.
