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Dictyota dichotoma specimens from the Egyptian coastal water of Hurghada City, the Red Sea. Scale bar = 2 cm.
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Although a broad variety of classes of bioactive compounds have already been isolated from seaweeds of the genus Dictyota, most different species are still chemically and biologically unexplored. Dictyota species are well-known brown seaweeds belonging to the Dictyotaceae (Phaeophyta). The phytochemical composition within the genus Dictyota has rec...
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... family Dictyotaceae has given rise to a great number of diterpenes generally grouped in three types: xenicanes, extended sesquiterpenes, and dolabellanes. One of the main seaweeds, named Dictyota dichotoma (Figure 1), grows on the coral reefs of Hurghada (the Red Sea, Egypt). The species D. dichotoma is the most widely distributed member of this family. ...
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... (246) and 4-hydroxydictyolactone (250) effectively inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse peritoneal macrophages (PEMФ), with inhibition rates of 76.0% and 53.2%, respectively, at 10.0 μM, whereas the other compounds showed only weak activities [114]. (1S,2S,3E,5Z,7E,11R,12R)-2-acetoxy-12-hydroxydolabella-3,5,7-trien-9-one (251) (Figure 9), (1S,2S,3E,5Z,7Z,11R,12R)-2-acetoxy-12-hydroxydolabella-3,5,7-trien-9-one (252), (1S,2S,3S,4Z,6Z,8R,11R,12R)-2-acetoxy-12-hydroxydolasta -4,6-dien-9-one (253), 9α-hydroxydictyol E (254), isodictyol E (255), 3β-acetoxydilophol (256), and 19-acetyl-4-hydroxydictyodiol (257) ( Figure 10) were found in D. plectens collected from the South China Sea [115]. ...
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... D. spinulosa, collected from Kin, Okinawa (Japan), hydroxydictyodial (258) (Fig- ure 10) was found. In feeding tests with Mozambique tilapia (Oreochromis mossambicus), it acted as an antifeedant diterpene [118], ...
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... A (259), (1R,3S,4S,7E,11S,12S)-3,4-epoxy-7,18-dolabelladiene (260), (1R,3S,4S,7E,11S,12S,14S)-3,4-epoxy-14-hydroxy-7,18-dolabelladiene (261), (1R,3S,4S,7E,11S,12S)-3,4-epoxy-14-oxo-7,18-dolabelladiene (262), (1R,3E,7E,11S,12S)-14-oxo-3,7,18-dolabellatriene (263), and (1R,3Z,7E,11S,12S)-14-oxo-3,7,18-dolabellatriene (264) ( Figure 10 Dictyotadimer A (274), a dissymmetric C40 bis-diterpene, characterized by a C-C linkage between two different xenicane units, was discovered in the Mediterranean Sea grass Dictyota sp. [121]. ...
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... (275) is the first nitrogen-containing xenicane diterpene detected in Dictyota sp., collected from the Senegalese Coast [122]. 16-Acetoxy-1R,11S,12R-dolabella-triene (276) and 3S-acetoxy-1R,11S,12R-dolabella-triene (277) (Figure 10) are minor dolabellane diterpenoid constituents from a Dictyota sp. [123]. ...
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... The three hydroazulenoid diterpenes dictyotriol C (278), dictyotriol D (279), and dictyotriol E (280), along with α-dictalediol monoacetate (281) (Figure 10), were identified in Dictyota sp., collected from the Canary Islands [124,125]. Pachydictyol C (111), Dictyol E (112), and 3,4-epoxy-7,18-dolabelladiene have been identified in D. spiralis collected along the coast of Tunisia. ...
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... industrial applications as a source of biofuels and agricultural applications as a source of growth-promoting agents of this species are imaginable, but have not been sufficiently studied yet. The publication rate regarding Dictyota has been rising vigorously within the past five years (Figure 11), illustrating the rapidly growing interest in this intriguing genus. So far, 25 species names of Dictyota, representing 24.5% of the current species, have been accepted taxonomically and investigated for their chemical and pharmacological activities (Figure 12), of which the most studied species as a possible drug source is D. dichotoma. ...
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... publication rate regarding Dictyota has been rising vigorously within the past five years (Figure 11), illustrating the rapidly growing interest in this intriguing genus. So far, 25 species names of Dictyota, representing 24.5% of the current species, have been accepted taxonomically and investigated for their chemical and pharmacological activities (Figure 12), of which the most studied species as a possible drug source is D. dichotoma. Several bioactive compounds with most diverse chemical structures have been reported, including diterpenes sesquiterpenes, carotenoids, hydrocarbons, terpenes, sterols, and sulfated polysaccharides (Figures 2-10, Tables S1 and S2). ...
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... far, 25 species names of Dictyota, representing 24.5% of the current species, have been accepted taxonomically and investigated for their chemical and pharmacological activities (Figure 12), of which the most studied species as a possible drug source is D. dichotoma. Several bioactive compounds with most diverse chemical structures have been reported, including diterpenes sesquiterpenes, carotenoids, hydrocarbons, terpenes, sterols, and sulfated polysaccharides (Figures 2-10, Tables S1 and S2). These isolated compounds and/or extracts displayed diverse biological activities such as antiproliferative, antimicrobial, antiviral, antioxidant, anti-inflammatory, and anti-hyperpigmentation activities. ...
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... family Dictyotaceae has given rise to a great number of diterpenes generally grouped in three types: xenicanes, extended sesquiterpenes, and dolabellanes. One of the main seaweeds, named Dictyota dichotoma (Figure 1), grows on the coral reefs of Hurghada (the Red Sea, Egypt). The species D. dichotoma is the most widely distributed member of this family. ...
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... (246) and 4-hydroxydictyolactone (250) effectively inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse peritoneal macrophages (PEMΦ), with inhibition rates of 76.0% and 53.2%, respectively, at 10.0 µM, whereas the other compounds showed only weak activities [114]. (1S,2S,3E,5Z,7E,11R,12R)-2-acetoxy-12-hydroxydolabella-3,5,7-trien-9-one (251) (Figure 9), (1S,2S,3E,5Z,7Z,11R,12R)-2-acetoxy-12-hydroxydolabella-3,5,7-trien-9-one (252), (1S,2S,3S,4Z,6Z,8R,11R,12R)-2-acetoxy-12-hydroxydolasta -4,6-dien-9-one (253), 9α-hydroxydictyol E (254), isodictyol E (255), 3β-acetoxydilophol (256), and 19-acetyl-4-hydroxydictyodiol (257) ( Figure 10) were found in D. plectens collected from the South China Sea [115]. ...
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... D. spinulosa, collected from Kin, Okinawa (Japan), hydroxydictyodial (258) (Figure 10) was found. In feeding tests with Mozambique tilapia (Oreochromis mossambicus), it acted as an antifeedant diterpene [118], ...
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... (275) is the first nitrogen-containing xenicane diterpene detected in Dictyota sp., collected from the Senegalese Coast [122]. 16-Acetoxy-1R,11S,12R-dolabella-triene (276) and 3S-acetoxy-1R,11S,12R-dolabella-triene (277) (Figure 10) are minor dolabellane diterpenoid constituents from a Dictyota sp. [123]. ...
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... The three hydroazulenoid diterpenes dictyotriol C (278), dictyotriol D (279), and dictyotriol E (280), along with α-dictalediol monoacetate (281) (Figure 10), were identified in Dictyota sp., collected from the Canary Islands [124,125]. Pachydictyol C (111), Dictyol E (112), and 3,4-epoxy-7,18-dolabelladiene have been identified in D. spiralis collected along the coast of Tunisia. ...
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... industrial applications as a source of biofuels and agricultural applications as a source of growth-promoting agents of this species are imaginable, but have not been sufficiently studied yet. The publication rate regarding Dictyota has been rising vigorously within the past five years (Figure 11), illustrating the rapidly growing interest in this intriguing genus. So far, 25 species names of Dictyota, representing 24.5% of the current species, have been accepted taxonomically and investigated for their chemical and pharmacological activities (Figure 12), of which the most studied species as a possible drug source is D. dichotoma. ...
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... publication rate regarding Dictyota has been rising vigorously within the past five years (Figure 11), illustrating the rapidly growing interest in this intriguing genus. So far, 25 species names of Dictyota, representing 24.5% of the current species, have been accepted taxonomically and investigated for their chemical and pharmacological activities (Figure 12), of which the most studied species as a possible drug source is D. dichotoma. Several bioactive compounds with most diverse chemical structures have been reported, including diterpenes sesquiterpenes, carotenoids, hydrocarbons, terpenes, sterols, and sulfated polysaccharides (Figures 2-10, Tables S1 and S2). ...
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... far, 25 species names of Dictyota, representing 24.5% of the current species, have been accepted taxonomically and investigated for their chemical and pharmacological activities (Figure 12), of which the most studied species as a possible drug source is D. dichotoma. Several bioactive compounds with most diverse chemical structures have been reported, including diterpenes sesquiterpenes, carotenoids, hydrocarbons, terpenes, sterols, and sulfated polysaccharides (Figures 2-10, Tables S1 and S2). These isolated compounds and/or extracts displayed diverse biological activities such as antiproliferative, antimicrobial, antiviral, antioxidant, anti-inflammatory, and anti-hyperpigmentation activities. ...
Citations
... For instance, herpes simplex virus type 1 infection in Vero cells was suppressed by dierpenes isolated from Dictyota pfaffii and Dictyota menstrualis. Diterpenes from D. menstrualis were tested for HIV-1 resistance [112,113,114]. ...
Microalgae (MiA) have been portrayed as a sustainable alternative for conventional sources of biofuels, several food and feed systems, and renewable energy sources. Microalgal biomass has attracted considerable attention for its potential to produce high quantities of value-added compounds, including pigments, vitamins, polyunsaturated fatty acids (PUFAs), and antioxidants. In this context, a plethora of existing and potential studies and reviews elicit the applied technologies for bio valorization of algal biomass and sustainable and integrated biorefinery approaches for production of high-value products. The focus of the present review is to provide insights on current trends in the production of lipids and pigments from the alga biomass, and employing eco-conscious methodologies for the extraction of compounds from the microalgal biosphere holds significant importance.
... High-cholesterol macrophages are a defining feature of atherogenesis [38]. Rhamnazin (20) is well known for its medicinal activities because of its antibacterial, antitumor, antiangiogenic, and antioxidant properties [39]. To stop acute lung damage from happening, Rhamnazin (20) potential as an antioxidant and anti-inflammatory drug was investigated. ...
Traditional medicine remains an alternative care option for most poor countries due to its inherent traits, unique and holistic approaches, accessibility, and cost. The current review aims to provide a comprehensive and up-to-date compilation of documented traditional medicinal uses, phytochemicals, and pharmacological activities of invasive R. cathartica and R. disperma, as well as valuable information to support its use as an alternative medicine in future healthcare practice. The genus Rhamnus, commonly called buckthorns, belongs to the family Rhamnaceae. It is considered a fruit and is of nutritional interest owing to its low calories. This review demonstrated that R. cathartica and R. disperma have multifaceted pharmacological potential. Studies examining this compound antioxidant, anticancer, anti-inflammatory, antiviral, and antibacterial characteristics have drawn attention to its effectiveness. Only a small number of research have looked specifically at R. disperma; instead, most studies have looked at R. cathartica, leading to generalized conclusions attributed to the group of compounds rather than the individual component. This paper covers Egyptian Buckthorns' chemistry and pharmacological potential, including their mechanism of action whenever applicable.
... Morphological cell changes included alterations in cell shape, size, and other visible characteristics. In this case, campesterol's cytotoxic activity was considered moderate, while cisplatin served as the positive control with higher cytotoxic activity [31,32] (Figure 4). The results of the campesterol cytotoxic test on several types of cells showed the most significant cell proliferation inhibition activity against melanoma skin cancer cells (B16-F10). ...
The pharmacological research of Manihot esculenta has stated the potential present as an interesting cytotoxic activity caused by several compounds contained in this species. However, the research on Melanoma Malignant cells (B16-F10 cancer cells) has never been studied. In this study, the steroid compounds isolated from the tuber of Sao Pedro Petro (1 variety of species M. esculenta Crantz) were studied in vitro and further evaluated using the western blot technique. Three steroid compounds, namely β-sitosterol (1), Campesterol (2), and Cholesterol (3), were obtained from the n-hexane extract of fresh Cassava tubers (Manihot esculenta Crantz). The chemical structures of compounds 1 - 3 were determined through various spectroscopic techniques such as HR-TOFMS, and NMR (1H, 13C, DEPT 135 °, HMQC, HMBC, 1H-1H COSY), along with a comparison to previously reported spectral data. Additionally, the apoptotic signaling pathway was investigated using RT-qPCR and western blot analysis. Among the 3 compounds, Campesterol (2) exhibited the highest IC50 value and demonstrated significant inhibition of B16-F10 cell proliferation by inducing apoptosis through caspase-3 activation. In conclusion, our study is the first to show that steroid compounds isolated from M. esculenta have activity against B16-F10 cells. This provides insight that steroids have the potential as chemopreventive agents to treat melanoma skin cancer. HIGHLIGHTS Three steroid compounds, namely β-sitosterol, campesterol, and cholesterol, were isolated from the n-hexane extract of fresh cassava tubers (Manihot esculenta Crantz) and campesterol exhibited the highest cytotoxic activity against B16-F10 melanoma cells, with an IC50 value of 160.4 µg/mL Campesterol induced apoptosis in B16-F10 melanoma cells through caspase-3 activation Treatment with campesterol led to noticeable alterations in cell morphology, including changes in shape, size, and other visible characteristics, further supporting its cytotoxic effects on melanoma cells The research's novelty lies in its exploration of previously unreported steroid compounds from cassava tubers, particularly campesterol, and their cytotoxic effects on melanoma cells, along with insights into the underlying mechanisms of action These findings contribute to the growing body of knowledge on natural compounds with potential therapeutic applications in cancer treatment GRAPHICAL ABSTRACT
... (1R,3R,4S,11R)-3,4;7,8-Bisepoxydolabellan-12(18)ene (6) is a dolabellane diterpene, typical product of algae of the genus Dictyota (Rushdi et al. 2022b); this mixing (Dictyota and Dictyopteris) must have occurred during the collection process. The cytotoxic potential obtained results revealed that the ethanol extract of D. acrostichoides had promising cytotoxicity activities against HepG2, MCF-7, and Caco-2 cell lines with IC 50 values of 11. 65,9.28,and ...
Ethanol extracts of Caulerpa racemose (Forsskål) J.Agardh, 1873, Dictyopteris acrostichoides (J.Agardh) Bornet, 1885, Halimeda opuntia (Linnaeus) J.V.Lamouroux, 1816, and Polycladia myrica (S.G.Gmelin) Draima, Ballesteros, F.Rousseau & T.Thibaut, 2010, were tested for their cytotoxicity against human hepatoma, human breast adenocarcinoma, and human colon adenocarcinoma cell lines. Dictyopteris acrostichoides displayed cytotoxicity against human hepatoma, human breast adenocarcinoma, and human colon adenocarcinoma with IC 50 values of 11.65, 9.28, and 16.86 µg/ml, respectively, in comparison to doxorubicin as a positive control (IC 50 5.72, 5.17, and 5.81 µg/ml, respectively). Metabolic profiling of the D. acrostichoides extract characterized seventeen metabolites. In silico analysis indicated 1-(3-oxo-undecyldisulfanyl)-undecan-3-one was the most active epidermal growth factor receptor inhibitor, while 1-(3-oxo-undecyldisulfanyl)-undecan-3-one and di(3-acetoxy-5-undecenyl) disulfide were the most active vascular endothelial growth factor inhibitors. Furthermore, the ethanol extract of D. acrostichoides was tested against epidermal growth factor receptor kinase (IC 50 0.11 µg/ml) compared to lapatinib as a positive control (IC 50 0.03 µg/ml), and against vascular endothelial growth factor (IC 50 0.276 µg/ml) compared to sorafenib as a positive control (IC 50 0.049 µg/ml).
Graphical Abstract
... (Figure 20c) have exhibited antibacterial effects against various pathogens, including S. aureus and Streptococcus mutans [87,88]. The antimicrobial activity is attributed to the presence of compounds like halimedatetraacetate [89]. ...
Cite this article: Pereira L, Valado A. Harnessing the power of seaweed: unveiling the potential of marine algae in drug discovery. Explor Drug Sci. 2023;1:475-96. https://doi. Abstract Seaweeds, also known as marine algae, have gained attention as a promising source of bioactive compounds with potential applications in drug discovery. This review explores the emerging field of seaweed-based drug discovery and highlights the diverse range of bioactive compounds found in seaweeds, including polysaccharides, phlorotannins, pigments, and peptides. These compounds exhibit various pharmacological activities such as antioxidant, anti-inflammatory, antimicrobial, antiviral, and anticancer effects. Seaweeds have demonstrated particular promise in the areas of cancer research, with certain species showing potent antitumor properties. Additionally, their anti-inflammatory, antimicrobial, and neuroprotective potential has captured scientific interest in the treatment of chronic diseases and neurodegenerative disorders. However, challenges related to compound identification, extraction methods, scalability of seaweed cultivation, and understanding the mechanisms of action still need to be addressed. As researchers employ advanced technologies and dive deeper into the chemical composition of seaweeds, the untapped potential of these marine organisms in drug discovery awaits further exploration and holds significant promise for future therapeutic advancements.
... Among the brown seaweeds Dictyota bartayresiana which belongs to the class Dictyotales is distributed worldwide and found abundantly in tropical than temperate aquatic bodies. The thalli are erect which forms hemispherical tufts and are attached to the rhizoids which are un-uniform and dichotomously branched with hair tufts [24]. Even though it has various applications due to its bitter taste and nonedible nature it remains as a weed of importance. ...
The present study validates the impact of nickel oxide nanoparticles (NiONPs) biosynthesized from the brown seaweed Dictyota bartayresiana (DB) and its biological applications. The phytochemicals analyzed in the seaweed extract served as a reducing, capping or stabilizing agent in the formation of nanoparticles. UV visible spectrum of nickel oxide nanoparticles synthesized from DB (DB-NiONPs) represented a prominent peak at 392 nm which validates its formation. Fourier Transmission Infrared Spectroscopy (FT-IR) showcased the presence of functional groups in the biomolecules which aids in the stabilization of DB-NiONPs. The X-ray diffractometry (XRD) revealed the crystalline nature of DB-NiONPs and the particle size was calculated as 18.26 nm. The Scanning electron microscope (SEM) illustrates the irregularly shaped DB-NiONPs and the desired elements were depicted in energy dispersive X-ray (EDX) spectrum which confirms the purity of DB-NiONPs. The DB-NiONPs efficiently decolorised the Black B133 (BB133) dye to 86% in 25 min. The data of adsorption studies well fitted into Langmuir isotherm and pseudo-second order kinetic model. The thermodynamic study substantiated the spontaneous, feasible and endothermic process of adsorption. DB-NiONPs revealed enhanced antimicrobial, larvicidal and nematicidal activities against the selected microbes, larva of Culex pipens and juveniles of Meloidogyne incognita respectively. The phytotoxicity studies revealed the DB-NiONPs had a positive impact on the germination and growth of green gram seedlings.
... Entre as fontes potenciais de biomoléculas marinhas, as macroalgas são consideradas fontes prolíficas de metabólitos biotecnologicamente úteis e possuem um amplo espectro de efeitos terapêuticos (RUSHDI et al., 2022b). Estes organismos têm mostrado potencial para aplicação em diferentes setores industriais como: alimentício (KUMAR; TARAFDAR; BADGUJAR, 2021; PEREIRA; RIBEIRO-CLARO, 2014;POLAT et al., 2021), bioenergético (KUMAR et al., 2018), agrícola (MAGCANTA et al., 2021), cosmeocêutico (SALEHI et al., 2019) e farmacêutico (CAVAS; POHNERT, 2010;RUSHDI et al., 2022a;SABRY et al., 2019). ...
... O gênero Dictyota é o mais estudado dentre as algas da família Dictyotaceae, principalmente devido à potencialidade dos seus diterpenos. Recentemente, foram publicadas três revisões (BOGAERT; DELVA; CLERCK, 2020;CHEN et al., 2018;RUSHDI et al., 2022b) dedicadas a apresentar a composição ficoquímica e o potencial biotecnológico de espécies de Dictyota. Chen e colaboradores (2018) resumiram diterpenos (233 estruturas) derivados do gênero Dictyota de 1988 até o final de 2017, classificando-os de acordo com o tipo de esqueleto: guaianos prenilados, dolabelanos, dolastanos, secodoslatanos, dictioxetano, xenicano, crenulidano, dicotomanos e crenulanos. ...
... As algas do gênero Dictyota são formadas por células paraquimatosas e talos em forma de fita com margens dentadas, crenuladas ou ciladas (RUSHDI et al., 2022b;SAHOO;YARISH, 2015). Este gênero compreende cerca de 97 espécies (GUIRY; GUIRY, 2021) distribuídas pelos mares tropicais e temperados quentes. ...
In recent years, research into the marine environment has increased, resulting in a wide variety of compounds with a significant diversity of biological activities. Thus, seaweed is a promising source of molecules with biotechnological and pharmaceutical interest. Brown algae of the Dictyotaceae family contribute an important percentage to the structural diversity of natural products, which have already demonstrated antifungal, antibacterial, antiviral potential, in addition to exercising multiple ecological functions in algae. Most species belong to the genera Dictyota, Lobophora and Padina, being known to produce diterpenes, sterols, fatty acids and polysaccharides. Thus, the objective of this review is to provide an updated overview of the natural products produced by the Dictyotaceae family, highlighting their antioxidant and antifungal activities. This review opens the way for discussion on the use of marine biodiversity for the development and innovation of new bioproducts, promoting a critical approach to bioprospecting, sustainability and conservation of marine brown algae.
... Several bioactives from D. dichotoma have been previously reported, including two compounds, dictyohydroperoxide and hydroperoxyacetoxycrenulide, containing hydroperoxyl groups rarely found in algal terpenoids, and two diterpenoids, namely pachydictyol B and pachydictyol C [9]. Many researchers have recently given a great deal of attention to the genus, due to its economic significance as an animal feed and antibiofouling and medicinal agent, overthe past 10 years [10]. However, research exploring seaweed resources in Pakistan is poorly elicited although it has enormous potential [11]. ...
Seaweed has been known to possess beneficial effects forhuman health due to the presence of functional bioactive components. The n-butanol and ethyl acetate extracts of Dictyota dichotoma showed ash (31.78%), crude fat (18.93%), crude protein (14.5%), and carbohydrate (12.35%) contents. About 19 compounds were identified in the n-butanol extract, primarily undecane, cetylic acid, hexadecenoic acid, Z-11-, lageracetal, dodecane, and tridecane, whereas 25 compounds were identified in the ethyl acetate extract, mainly tetradecanoic, hexadecenoic acid, Z-11-, undecane, and myristic acid. FT-IR spectroscopy confirmed the presence of carboxylic acid, phenols, aromatics, ethers, amides, sulfonates, and ketones. Moreover, total phenolic contents (TPC) and total flavonoid contents (TFC) in ethyl acetate extract were 2.56 and 2.51 mg GAE/g and in n-butanol extract were 2.11 and 2.25 mg QE/g, respectively. Ethyl acetate and n-butanol extracts at a high concentration of 100 mg mL−1 showed 66.64 and 56.56 % inhibition of DPPH, respectively. Antimicrobial activity revealed that Candida albicans was the most susceptible microorganism, followed by Bacillus subtilis, Staphylococcus aureus, and Escherichia coli, whereas Pseudomonas aeruginosa showed the least inhibition at all concentrations. The in vivo hypoglycemic study revealed that both extracts exhibited concentration-dependent hypoglycemic activities. In conclusion, this macroalgae exhibited antioxidant, antimicrobial, and hypoglycemic potentials.
... As can be seen from Table 2, among the saturated fatty acids, the highest content was obtained for myristic acid (C14:0) in D. dichotoma and palmitic acid (c16:0) in D. fasciola, which agrees with the published data [55], where the most abundant SFAs in the D. bartayresii were also C16:0 and C14:0. Other research reported the presence of palmitic, linoleic, and arachidonic acid in D. dichotoma samples [56], which is also in agreement with the results obtained in our study ( Table 2). There were 21 fatty acids in total found in D. dichotoma, and 15 of them were found in the D. fasciola sample. ...
... Consequently, we may assume that fucoxanthin is one of the components responsible for the observed antioxidant activity of F3 fractions. Additionally, a determined diterpenoid only in the D. dichotoma F3 fraction, amijitrienol (Table 3), is reported to have antioxidant and anti-tumor activity [54,56,58], while loliolide, present in the F3 fractions of both D. dichotoma and D. fasciola was reported to exhibit strong antioxidant activity [67]. By implementing ABTS assay, the highest inhibition was observed for D. fasciola F4, followed by the D. dichotoma F3 fraction. ...
The marine environment has a significant impact on life on Earth. Organisms residing in it are vital for the ecosystem but also serve as an inexhaustible source of biologically active compounds. Herein, the biodiversity of two brown seaweeds, Dictyota dichotoma and Dictyota fasciola from the Adriatic Sea, was evaluated. The aim of the study was the determination of differences in compound composition while comparing their activities, including antioxidant, antimicrobial, and enzyme inhibition, in connection to human digestion, dermatology, and neurological disorders. Chemical analysis revealed several terpenoids and steroids as dominant molecules, while fucoxanthin was the main identified pigment in both algae. D. dichotoma had higher protein, carbohydrate, and pigment content. Omega-6 and omega-3 fatty acids were identified, with the highest amount of dihomo-γ-linolenic acid and α-linolenic acid in D. dichotoma. Antimicrobial testing revealed a dose-dependent inhibitory activity of methanolic fraction against Escherichia coli and Staphylococcus aureus. Moderate antioxidant activity was observed for both algae fractions, while the dietary potential was high, especially for the D. fasciola dichloromethane fraction, with inhibition percentages of around 92% for α-amylase and 57% for pancreatic lipase at 0.25 mg/mL. These results suggest that Dictyota species might be a potent source of naturally derived agents for obesity and diabetes.
... Extracts from brown algae species of the genus Dictyota have also demonstrated possible anticancer, antiviral, antifungal, antileishmanial, antitrypanosomal and antioxidant activities [48]. Another important discovery is associated with the display of antiviral activity against Herpes Simplex Virus and Human Immunodeficiency Virus [53]. ...
... As a contribution to the cosmeceutical field, the discovery of the diterpene compound from the D. coriacea species revealed positive anti-melanogenesis effects to be used in case of excess melanin production, which can cause hyperpigmentation in the skin such as freckles and age spots [48,54]. Dermal applications of the genus Dictyota have already been reported in investigations, such as their potential for the treatment of alopecia, but until now, there has been no reports of these compounds being used in the production of cosmetics [53]. ...
... In the textile industry, Dictyota also plays a role in fabric engineering [53,55], normally used as a binding or thickening material for yarns, promptly reducing yarn tearing during the weaving process [55]. ...
The brown macroalgae of the species Rugulopteryx okamurae has reached European waters and the Strait of Gibraltar as an invasive species. The proliferation and colonization of the species in subtidal and intertidal zones of these regions imposes significant threats to local ecosystems and additionally represents a significant socioeconomic burden related to the large amounts of biomass accumulated as waste. As a way to minimize the effects caused by the accumulation of algae biomass, investigations have been made to employ this biomass as a raw material in value-added products or technologies. The present review explores the potential uses of R. okamurae, focusing on its impact for biogas production, composting, bioplastic and pharmaceutical purposes, with potential anti-inflammatory, antibacterial and α-glucosity inhibitory activities being highlighted. Overall, this species appears to present many attributes, with remarkable potential for uses in several fields of research and in various industries.
