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Diagram showing heart chambers and blood fl ow (Mayo Clinic acknowledged).
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Sildenafil citrate is one of the frontline drugs used to manage erectile dysfunction (ED). Chemically, it is described as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H –pyrazolo [4,3-d]pyrimidin-5-yl)-4 ethoxyphenyl] sulfonyl]-4-methylpiperazine citrate (C22H30N6O4 S). It is a highly selective inhibitor of cyclic guanine monophosphate-specific phos...
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The use of lemon (Citrus limon) and lime (Citrus aurantifolia) juices for the treatment of erectile dysfunction (ED) is fast becoming common practice, even though there is dearth of information on the effect of such functional food and drug combination in the management of ED. This study evaluated the effect of lemon and lime juices on the erectoge...
Citations
... According to this action, sildenafil promotes and prolongs the duration of erection of penis and treat pulmonary hypertension. 3 The great part of SC metabolized in the liver, so there are precautions when giving sildenafil to children, and patients with liver diseases 4 . The process of aging predisposes to hepatic functional, metabolic, and structural changes 5 . ...
... These AGEs are associated with chronic inflammation, which in turn leads to microvascular complications, especially in the kidneys, eyes, and nerves [2]. Sildenafil citrate (SC) is a phosphodiesterase type 5 (PDE-5) inhibitor, so its role in vasodilation is widely known [3] and is commonly used to treat erectile dysfunction. It has also been investigated for the treatment of several other conditions, including lupus rheumatoid arthritis, and pulmonary hypertension, and its clinical effects were approved for treating several cardiovascular and obstructive pulmonary diseases in men [2,4]. ...
... It has also been investigated for the treatment of several other conditions, including lupus rheumatoid arthritis, and pulmonary hypertension, and its clinical effects were approved for treating several cardiovascular and obstructive pulmonary diseases in men [2,4]. The effect of sildenafil is to raise cyclic guanosine monophosphate (cGMP) levels by rendering cGMP-metabolizing PDEs inactive [3]. At the intracellular level, cGMP mediates the nitric oxide (NO) pathway, increasing its synthesis. ...
