Figure - available from: Clinical & Translational Immunology
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Diagnostic sensitivities and specificities of ACPA fine specificities. (a) Receiver operating characteristic (ROC) curves obtained with ACPA fine specificities compared to anti‐CCP2 antibodies and to anti‐human citrullinated fibrinogen antibodies (AhFibA) tested on 180 RA sera and 200 non‐RA control sera. Citrullinated peptides are derived from the α (α36‐50, α621‐635, α501‐515) or β (β60‐74, β36‐52) chain of human fibrin, α‐enolase (CEP), vimentin (Vim) or Epstein–Barr virus nuclear antigen 1 (EBNA). (b) Statistical analysis of all possible paired comparisons of the diagnostic sensitivities (Se) of the different ACPA at 95 % specificity (Sp) thresholds and areas under curves (AUCs).
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Background
In rheumatoid arthritis (RA), antibodies to citrullinated protein (ACPA) are believed to be heterogeneous and patient stratification by antibody profiling raised clinical interest for patient management. However, heterogeneity might be partially artificial because of the use of heterogeneous methods for ACPA detection. In recent work ins...
